{"id":611,"title":"Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes","short_name":"Behavioral abnormalities due to increased expression of dopamine-related genes","created_at":"2025-10-19T21:29:21.000-04:00","updated_at":"2026-06-26T16:12:15.000-04:00","corresponding_author":{"id":21139,"created_at":"2026-06-26T16:11:56.000-04:00","updated_at":"2026-06-26T17:14:26.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":2379,"event":"Disruption of the regulatory function of dopamine signaling components.","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2380,"event":"Increase, transcription of the dopamine transporter (SLC6A3) gene","event_type":"KeyEvent"},{"event_id":2381,"event":"Increase, transcription of the dopamine receptor (drd) gene.","event_type":"KeyEvent"},{"event_id":746,"event":"Increase, Dopaminergic activity","event_type":"KeyEvent"},{"event_id":602,"event":"Increased, Ataxia, paralysis, or hyperactivity","event_type":"KeyEvent"},{"event_id":1005,"event":"Reduced, Swimming performance","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2382,"event":"Increase, nerve spasm","event_type":"AdverseOutcome"}],"relationships":[{"relation":4626,"upstream_event_id":2379,"upstream_event":"Disruption of the regulatory function of dopamine signaling components.","downstream_event_id":2380,"downstream_event":"Increase, transcription of the dopamine transporter (SLC6A3) gene"},{"relation":4627,"upstream_event_id":2379,"upstream_event":"Disruption of the regulatory function of dopamine signaling components.","downstream_event_id":2381,"downstream_event":"Increase, transcription of the dopamine receptor (drd) gene."},{"relation":4628,"upstream_event_id":2380,"upstream_event":"Increase, transcription of the dopamine transporter (SLC6A3) gene","downstream_event_id":746,"downstream_event":"Increase, Dopaminergic activity"},{"relation":4629,"upstream_event_id":2381,"upstream_event":"Increase, transcription of the dopamine receptor (drd) gene.","downstream_event_id":746,"downstream_event":"Increase, Dopaminergic activity"},{"relation":4630,"upstream_event_id":746,"upstream_event":"Increase, Dopaminergic activity","downstream_event_id":602,"downstream_event":"Increased, Ataxia, paralysis, or hyperactivity"},{"relation":4631,"upstream_event_id":602,"upstream_event":"Increased, Ataxia, paralysis, or hyperactivity","downstream_event_id":1005,"downstream_event":"Reduced, Swimming performance"},{"relation":4632,"upstream_event_id":1005,"upstream_event":"Reduced, Swimming performance","downstream_event_id":2382,"downstream_event":"Increase, nerve spasm"}]}