25614-03-3 OZVBMTJYIDMWIL-AYFBDAFISA-N OZVBMTJYIDMWIL-AYFBDAFISA-N Bromocriptine Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'α)- 2-Bromoergocriptine 2-Bromoergocryptine 2-Bromo-α-ergocryptine 2-Bromo-α-ergokryptine Bromergocryptine Bromocriptin bromocriptina Bromocryptine Bromoergocryptine Ergocryptine, 2-bromo- Sandoz 15-754 α-Bromocryptine α-Bromoergocryptine DTXSID1022687 GO:0001963 GO synaptic transmission, dopaminergic MP:0001393 MP ataxia MP:0001399 MP hyperactivity MP:0000753 MP paralysis NBO:0000371 NBO aquatic locomotion 1 WIKI increased 2 WIKI decreased Bromocriptine 2016-11-29T18:42:27 2016-11-29T18:42:27 WCS_7955 common ecological species zebrafish 70862 NCBI teleost fish WCS_90988 common ecological species fathead minnow Disruption, regulatory function of dopamine signaling components. Molecular AOPWiki 2025-10-19T22:11:09 2025-10-19T22:11:09 Increase, dopamine transporter gene Molecular AOPWiki 2025-10-19T22:13:08 2025-10-19T22:13:08 Increase, dopamine receptor gene Molecular AOPWiki 2025-10-19T22:14:01 2025-10-19T22:14:01 Increase, Dopaminergic activity Cellular CL:0000700 CL dopaminergic neuron AOPWiki 2016-11-29T18:41:26 2017-09-16T10:16:09 Increased, Ataxia, paralysis, or hyperactivity Organ UBERON:0001134 UBERON skeletal muscle tissue AOPWiki 2016-11-29T18:41:25 2017-09-16T10:15:50 Reduced, Swimming performance Individual <p>Adequate swimming performance in fish is essential for behaviour such as foraging, predator avoidance and reproduction.</p> <p>For fish larvae, automated observation and tracking systems are commercially available and increasingly used for measuring swimming performance including distance travelled, duration of movements, swimming speed, etc. This kind of measurements is often included in publications describing effects of chemicals in zebrafish larvae (Hagenaars et al., 2014; Stinckens et al., 2016; Vergauwen et al., 2015).</p> <p>For juvenile and adult fish, measurements of swim performance vary. However, in some circumstances, swim tunnels&nbsp;have&nbsp;been used to measure various data (Fu et al., 2013).</p> <p>Little and Finger (1990) discussed swimming behavior as an indicator of sublethal toxicity in fish.</p> <p><strong>Taxonomic</strong>: Importance of swimming performance for natural behaviour is generally applicable to fish and tho other taxa that rely on swimming to support vital behaviours.</p> <p><strong>Life stage</strong>: Importance of swimming performance for natural behaviour is generally applicable across all free-swimming life stages, i.e., post-embryonic life stages.</p> <p><strong>Sex</strong>: Importance of swimming performance for natural behaviour is generally applicable across sexes.</p> High Unspecific Moderate Larvae Moderate Juvenile Moderate Adult High High High <p>Fu C, Cao ZD, Fu SJ. 2013. The effects of caudal fin loss and regeneration on the swimming performance of three cyprinid fish species with different swimming capactities. The Journal of Experimental Biology 216:3164-3174. doi:10.1242/jeb.084244</p> <p>Hagenaars, A., Stinckens, E., Vergauwen, L., Bervoets, L., Knapen, D., 2014. PFOS affects posterior swim bladder chamber inflation and swimming performanceof zebrafish larvae. Aquat. Toxicol. 157, 225&ndash;235.</p> <p>Little EE, Finger SE. 1990. Swimming behavior as an indicator of sublethal toxicity in fish. Environmental Toxicology and Chemistry. 9(1):13-19.</p> <p>Stinckens, E., Vergauwen, L., Schroeder, A.L., Maho, W., Blackwell, B., Witter, H.,Blust, R., Ankley, G.T., Covaci, A., Villenueve, D.L., Knapen, D., 2016. Disruption of thyroid hormone balance after 2-mercaptobenzothiazole exposure causes swim bladder inflation impairment&mdash;part II: zebrafish. Aquat. Toxicol. 173:204-17.</p> <p>Vergauwen, Lucia; N&oslash;rgaard Schmidt, Stine; Maho, Walid; Stickens, Evelyn; Hagenaars, An; Blust, Ronny; Mayer, Philipp; Covaci, Adrian; Knapen, Dries. 2014. A high throughput passive dosing format for the Fish Embryo Acute Toxicity test. Chemosphere. 139: 9-17.</p> AOPWiki 2016-11-29T18:41:28 2021-09-08T06:12:30 Increase, nerve spasm Individual AOPWiki 2025-10-20T00:12:11 2025-10-20T00:12:11 AOPWiki 2025-10-20T00:15:53 2025-10-20T00:15:53 AOPWiki 2025-10-20T00:16:19 2025-10-20T00:16:19 AOPWiki 2025-10-20T00:16:44 2025-10-20T00:16:44 AOPWiki 2025-10-20T00:16:55 2025-10-20T00:16:55 AOPWiki 2025-10-20T00:17:09 2025-10-20T00:17:09 AOPWiki 2025-10-20T00:18:18 2025-10-20T00:18:18 AOPWiki 2025-10-20T00:18:41 2025-10-20T00:18:41 Behavioral abnormalities due to increased expression of dopamine-related genes Arthur Author BY-SA 2.7 adjacent Moderate Moderate adjacent Moderate Moderate adjacent Moderate Moderate adjacent Moderate Moderate adjacent Moderate Moderate adjacent Moderate Moderate adjacent Moderate Moderate <div> <table class="table table-bordered table-fullwidth"> <thead> <tr> <th>Modulating Factor (MF)</th> <th>Influence or Outcome</th> <th>KER(s) involved</th> </tr> </thead> <tbody> <tr> <td>&nbsp;</td> <td>&nbsp;</td> <td>&nbsp;</td> </tr> </tbody> </table> </div> AOPWiki 2025-10-19T21:29:21 2026-06-26T16:12:15