{"id":612,"title":"Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate","short_name":"PPARα activation leading to ELS mortality via reduced ATP","created_at":"2025-10-29T17:12:01.000-04:00","updated_at":"2026-06-26T16:12:15.000-04:00","corresponding_author":{"id":21142,"created_at":"2026-06-26T16:11:56.000-04:00","updated_at":"2026-06-26T16:11:56.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":227,"event":"Activation, PPARα","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1312,"event":"Increase, Fatty acid beta-oxidation","event_type":"KeyEvent"},{"event_id":1446,"event":"Decrease, Coupling of oxidative phosphorylation","event_type":"KeyEvent"},{"event_id":1771,"event":"Decrease, Adenosine triphosphate pool","event_type":"KeyEvent"},{"event_id":2384,"event":"Decrease, Vascular integrity","event_type":"KeyEvent"},{"event_id":2383,"event":"Increase, Hemopericardium","event_type":"KeyEvent"}],"aop_aos":[{"event_id":947,"event":"Increase, Early Life Stage Mortality","event_type":"AdverseOutcome"}],"relationships":[{"relation":4633,"upstream_event_id":227,"upstream_event":"Activation, PPARα","downstream_event_id":1312,"downstream_event":"Increase, Fatty acid beta-oxidation"},{"relation":4634,"upstream_event_id":1312,"upstream_event":"Increase, Fatty acid beta-oxidation","downstream_event_id":1446,"downstream_event":"Decrease, Coupling of oxidative phosphorylation"},{"relation":4635,"upstream_event_id":1446,"upstream_event":"Decrease, Coupling of oxidative phosphorylation","downstream_event_id":1771,"downstream_event":"Decrease, Adenosine triphosphate pool"},{"relation":4636,"upstream_event_id":1771,"upstream_event":"Decrease, Adenosine triphosphate pool","downstream_event_id":2384,"downstream_event":"Decrease, Vascular integrity"},{"relation":4637,"upstream_event_id":2384,"upstream_event":"Decrease, Vascular integrity","downstream_event_id":2383,"downstream_event":"Increase, Hemopericardium"},{"relation":4638,"upstream_event_id":2383,"upstream_event":"Increase, Hemopericardium","downstream_event_id":947,"downstream_event":"Increase, Early Life Stage Mortality"}]}