{"id":613,"title":"Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production","short_name":"PPARα activation leading to ELS mortality via ROS","created_at":"2025-10-29T17:13:01.000-04:00","updated_at":"2026-06-26T16:12:16.000-04:00","corresponding_author":{"id":21143,"created_at":"2026-06-26T16:11:57.000-04:00","updated_at":"2026-06-26T16:11:57.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":227,"event":"Activation, PPARα","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1312,"event":"Increase, Fatty acid beta-oxidation","event_type":"KeyEvent"},{"event_id":1446,"event":"Decrease, Coupling of oxidative phosphorylation","event_type":"KeyEvent"},{"event_id":1115,"event":"Increase, Reactive oxygen species","event_type":"KeyEvent"},{"event_id":2384,"event":"Decrease, Vascular integrity","event_type":"KeyEvent"},{"event_id":2383,"event":"Increase, Hemopericardium","event_type":"KeyEvent"}],"aop_aos":[{"event_id":947,"event":"Increase, Early Life Stage Mortality","event_type":"AdverseOutcome"}],"relationships":[{"relation":4639,"upstream_event_id":227,"upstream_event":"Activation, PPARα","downstream_event_id":1312,"downstream_event":"Increase, Fatty acid beta-oxidation"},{"relation":4640,"upstream_event_id":1312,"upstream_event":"Increase, Fatty acid beta-oxidation","downstream_event_id":1446,"downstream_event":"Decrease, Coupling of oxidative phosphorylation"},{"relation":4641,"upstream_event_id":1446,"upstream_event":"Decrease, Coupling of oxidative phosphorylation","downstream_event_id":1115,"downstream_event":"Increase, Reactive oxygen species"},{"relation":4642,"upstream_event_id":1115,"upstream_event":"Increase, Reactive oxygen species","downstream_event_id":2384,"downstream_event":"Decrease, Vascular integrity"},{"relation":4643,"upstream_event_id":2384,"upstream_event":"Decrease, Vascular integrity","downstream_event_id":2383,"downstream_event":"Increase, Hemopericardium"},{"relation":4644,"upstream_event_id":2383,"upstream_event":"Increase, Hemopericardium","downstream_event_id":947,"downstream_event":"Increase, Early Life Stage Mortality"}]}