{"id":614,"title":"Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor","short_name":"PPARα activation leading to ELS mortality via reduced VEGF","created_at":"2025-10-29T17:14:10.000-04:00","updated_at":"2026-06-26T16:12:16.000-04:00","corresponding_author":{"id":21136,"created_at":"2026-06-26T16:11:56.000-04:00","updated_at":"2026-06-26T16:11:56.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":227,"event":"Activation, PPARα","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":948,"event":"reduced production, VEGF","event_type":"KeyEvent"},{"event_id":28,"event":"Reduction, Angiogenesis","event_type":"KeyEvent"},{"event_id":2383,"event":"Increase, Hemopericardium","event_type":"KeyEvent"}],"aop_aos":[{"event_id":947,"event":"Increase, Early Life Stage Mortality","event_type":"AdverseOutcome"}],"relationships":[{"relation":4645,"upstream_event_id":227,"upstream_event":"Activation, PPARα","downstream_event_id":948,"downstream_event":"reduced production, VEGF"},{"relation":4646,"upstream_event_id":948,"upstream_event":"reduced production, VEGF","downstream_event_id":28,"downstream_event":"Reduction, Angiogenesis"},{"relation":4647,"upstream_event_id":28,"upstream_event":"Reduction, Angiogenesis","downstream_event_id":2383,"downstream_event":"Increase, Hemopericardium"},{"relation":4648,"upstream_event_id":2383,"upstream_event":"Increase, Hemopericardium","downstream_event_id":947,"downstream_event":"Increase, Early Life Stage Mortality"}]}