{"id":615,"title":"Suppression of Keap1 cysteine oxidation leading to liver inflammation","short_name":"Keap1 cysteine oxidation,liver failure","created_at":"2025-11-04T08:50:09.000-05:00","updated_at":"2026-06-26T16:12:16.000-04:00","corresponding_author":{"id":21137,"created_at":"2026-06-26T16:11:56.000-04:00","updated_at":"2026-06-26T16:11:56.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":725,"stressor_name":"All-trans retinoic acid"},{"stressor_id":853,"stressor_name":"Brusatol"},{"stressor_id":854,"stressor_name":"ML385"},{"stressor_id":454,"stressor_name":"Hydrogen peroxide"},{"stressor_id":335,"stressor_name":"Cadmium"},{"stressor_id":723,"stressor_name":"Zinc"}],"aop_mies":[{"event_id":2385,"event":"Suppression of Keap1 cysteine oxidation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1417,"event":"NFE2/Nrf2 repression","event_type":"KeyEvent"},{"event_id":1445,"event":"Increase, Lipid peroxidation","event_type":"KeyEvent"},{"event_id":1994,"event":"Increase, Ferroptosis","event_type":"KeyEvent"}],"aop_aos":[{"event_id":902,"event":"Inflammation, Liver","event_type":"AdverseOutcome"}],"relationships":[{"relation":4649,"upstream_event_id":2385,"upstream_event":"Suppression of Keap1 cysteine oxidation","downstream_event_id":1417,"downstream_event":"NFE2/Nrf2 repression"},{"relation":4652,"upstream_event_id":1994,"upstream_event":"Increase, Ferroptosis","downstream_event_id":902,"downstream_event":"Inflammation, Liver"},{"relation":4680,"upstream_event_id":1417,"upstream_event":"NFE2/Nrf2 repression","downstream_event_id":1445,"downstream_event":"Increase, Lipid peroxidation"},{"relation":4681,"upstream_event_id":1445,"upstream_event":"Increase, Lipid peroxidation","downstream_event_id":902,"downstream_event":"Inflammation, Liver"}]}