{"id":616,"title":"organic UV filter and its Photoproducts reproductive toxicity pathways ","short_name":"OUVFs and PTP AOP pathways in reproductive toxicity","created_at":"2025-11-06T04:55:02.000-05:00","updated_at":"2026-06-26T16:12:16.000-04:00","corresponding_author":{"id":21138,"created_at":"2026-06-26T16:11:56.000-04:00","updated_at":"2026-06-26T16:11:56.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":2387,"event":"MIE-A: Direct ligand interaction with nuclear hormone receptors (ERα/ERβ, AR) or interference with steroidogenic enzymes (e.g., CYP19A1) → receptor activation/antagonism or enzyme inhibition.","event_type":"MolecularInitiatingEvent"},{"event_id":2388,"event":"MIE-B: Photoactivation / photoproduct formation leading to ROS generation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2389,"event":"KE1: Altered steroidogenesis (gene/protein level)","event_type":"KeyEvent"},{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"KeyEvent"},{"event_id":2363,"event":"Elevated mitochondrial ROS and dysfunction","event_type":"KeyEvent"},{"event_id":1262,"event":"Apoptosis","event_type":"KeyEvent"},{"event_id":2390,"event":"KE5: Altered circulating reproductive hormones","event_type":"KeyEvent"},{"event_id":363,"event":"Altered, Reproductive behaviour","event_type":"KeyEvent"},{"event_id":364,"event":"Impaired development of, Reproductive organs","event_type":"KeyEvent"},{"event_id":1757,"event":"Reduce, Sperm count","event_type":"KeyEvent"},{"event_id":971,"event":"Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation ","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2391,"event":"Reduced fertility / fecundity","event_type":"AdverseOutcome"}],"relationships":[{"relation":4653,"upstream_event_id":2387,"upstream_event":"MIE-A: Direct ligand interaction with nuclear hormone receptors (ERα/ERβ, AR) or interference with steroidogenic enzymes (e.g., CYP19A1) → receptor activation/antagonism or enzyme inhibition.","downstream_event_id":2389,"downstream_event":"KE1: Altered steroidogenesis (gene/protein level)"},{"relation":4660,"upstream_event_id":2388,"upstream_event":"MIE-B: Photoactivation / photoproduct formation leading to ROS generation","downstream_event_id":2389,"downstream_event":"KE1: Altered steroidogenesis (gene/protein level)"},{"relation":4654,"upstream_event_id":2388,"upstream_event":"MIE-B: Photoactivation / photoproduct formation leading to ROS generation","downstream_event_id":1392,"downstream_event":"Increase, Oxidative Stress "},{"relation":4661,"upstream_event_id":2388,"upstream_event":"MIE-B: Photoactivation / photoproduct formation leading to ROS generation","downstream_event_id":2363,"downstream_event":"Elevated mitochondrial ROS and dysfunction"},{"relation":4655,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":2363,"downstream_event":"Elevated mitochondrial ROS and dysfunction"},{"relation":4656,"upstream_event_id":2363,"upstream_event":"Elevated mitochondrial ROS and dysfunction","downstream_event_id":1262,"downstream_event":"Apoptosis"},{"relation":4657,"upstream_event_id":2389,"upstream_event":"KE1: Altered steroidogenesis (gene/protein level)","downstream_event_id":2390,"downstream_event":"KE5: Altered circulating reproductive hormones"},{"relation":4658,"upstream_event_id":1262,"upstream_event":"Apoptosis","downstream_event_id":2391,"downstream_event":"Reduced fertility / fecundity"},{"relation":4659,"upstream_event_id":2390,"upstream_event":"KE5: Altered circulating reproductive hormones","downstream_event_id":2391,"downstream_event":"Reduced fertility / fecundity"}]}