{"id":619,"title":"Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues","short_name":"AR agonism leads to delayed PPS via reduced FGF expression","created_at":"2025-12-03T11:42:47.000-05:00","updated_at":"2026-06-26T16:12:16.000-04:00","corresponding_author":{"id":21143,"created_at":"2026-06-26T16:11:57.000-04:00","updated_at":"2026-06-26T16:11:57.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":26,"event":"Antagonism, Androgen receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2393,"event":"Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced ","event_type":"KeyEvent"},{"event_id":2399,"event":"Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced","event_type":"KeyEvent"},{"event_id":2400,"event":"Preputial epithelial morphogenesis, disrupted","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2401,"event":"Male preputial separation, failed/delayed","event_type":"AdverseOutcome"}],"relationships":[{"relation":4670,"upstream_event_id":26,"upstream_event":"Antagonism, Androgen receptor","downstream_event_id":2393,"downstream_event":"Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced "},{"relation":4671,"upstream_event_id":2393,"upstream_event":"Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced ","downstream_event_id":2399,"downstream_event":"Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced"},{"relation":4672,"upstream_event_id":2399,"upstream_event":"Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced","downstream_event_id":2400,"downstream_event":"Preputial epithelial morphogenesis, disrupted"},{"relation":4673,"upstream_event_id":2400,"upstream_event":"Preputial epithelial morphogenesis, disrupted","downstream_event_id":2401,"downstream_event":"Male preputial separation, failed/delayed"}]}