{"id":622,"title":"Calcineurin inhibitor induced nephrotoxicity leading to kidney failure","short_name":"Calcineurin inhibitor induced nephrotoxicity","created_at":"2026-01-07T12:08:28.000-05:00","updated_at":"2026-06-26T16:12:16.000-04:00","corresponding_author":{"id":21138,"created_at":"2026-06-26T16:11:56.000-04:00","updated_at":"2026-06-26T16:11:56.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":294,"stressor_name":"Cyclosporin"},{"stressor_id":163,"stressor_name":"Tacrolimus (also FK506)"}],"aop_mies":[],"aop_kes":[{"event_id":1172,"event":"Increased activation, Nuclear factor kappa B (NF-kB)","event_type":"KeyEvent"},{"event_id":1174,"event":"Activation, NADPH Oxidase","event_type":"KeyEvent"},{"event_id":1115,"event":"Increase, Reactive oxygen species","event_type":"KeyEvent"},{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"KeyEvent"},{"event_id":177,"event":"Increase, Mitochondrial dysfunction","event_type":"KeyEvent"},{"event_id":2403,"event":"Metabolic impairment ","event_type":"KeyEvent"},{"event_id":1283,"event":"Activation, TGF-beta pathway","event_type":"KeyEvent"},{"event_id":2404,"event":"Increase, kidney fibrosis","event_type":"KeyEvent"},{"event_id":1365,"event":"Increase, Apoptosis","event_type":"KeyEvent"}],"aop_aos":[{"event_id":759,"event":"Increased, Kidney Failure","event_type":"AdverseOutcome"}],"relationships":[]}