{"id":623,"title":"Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release","short_name":"Activation, ERα leads to persistent vaginal cornification via increased kisspeptin","created_at":"2026-01-29T10:46:44.000-05:00","updated_at":"2026-06-26T16:12:16.000-04:00","corresponding_author":{"id":21139,"created_at":"2026-06-26T16:11:56.000-04:00","updated_at":"2026-06-26T17:14:26.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1065,"event":"Activation, estrogen receptor alpha","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1985,"event":"Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)","event_type":"KeyEvent"},{"event_id":1047,"event":"Increased, secretion of GnRH from hypothalamus","event_type":"KeyEvent"},{"event_id":2137,"event":"Increase, Gonadotropins concentration in plasma","event_type":"KeyEvent"},{"event_id":2402,"event":"Increased, estradiol (E2) production in ovaries ","event_type":"KeyEvent"},{"event_id":2294,"event":"Plasma estradiol, increased","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2306,"event":"Persistent vaginal cornification","event_type":"AdverseOutcome"}],"relationships":[{"relation":4682,"upstream_event_id":1065,"upstream_event":"Activation, estrogen receptor alpha","downstream_event_id":1985,"downstream_event":"Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)"},{"relation":4683,"upstream_event_id":1985,"upstream_event":"Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)","downstream_event_id":1047,"downstream_event":"Increased, secretion of GnRH from hypothalamus"},{"relation":4684,"upstream_event_id":1047,"upstream_event":"Increased, secretion of GnRH from hypothalamus","downstream_event_id":2137,"downstream_event":"Increase, Gonadotropins concentration in plasma"},{"relation":4685,"upstream_event_id":2137,"upstream_event":"Increase, Gonadotropins concentration in plasma","downstream_event_id":2402,"downstream_event":"Increased, estradiol (E2) production in ovaries "},{"relation":4686,"upstream_event_id":2402,"upstream_event":"Increased, estradiol (E2) production in ovaries ","downstream_event_id":2294,"downstream_event":"Plasma estradiol, increased"},{"relation":4687,"upstream_event_id":2294,"upstream_event":"Plasma estradiol, increased","downstream_event_id":2306,"downstream_event":"Persistent vaginal cornification"}]}