{"id":624,"title":"Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction","short_name":"Increased 11β-HSD1 leading to MASLD via IR-associated mitochondrial dysfunction","created_at":"2026-02-10T08:19:03.000-05:00","updated_at":"2026-06-26T16:12:16.000-04:00","corresponding_author":{"id":21142,"created_at":"2026-06-26T16:11:56.000-04:00","updated_at":"2026-06-26T16:11:56.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":2410,"event":"Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity ","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2412,"event":"Increase, Hepatic intracellular active glucocorticoids","event_type":"KeyEvent"},{"event_id":122,"event":"Increase, Glucocorticoid receptor activation","event_type":"KeyEvent"},{"event_id":2119,"event":"Increase, Insulin resistance","event_type":"KeyEvent"},{"event_id":2408,"event":"Increase, Adipose lipolysis","event_type":"KeyEvent"},{"event_id":465,"event":"Increased, Fatty acid influx","event_type":"KeyEvent"},{"event_id":2405,"event":"Increase, Hepatocellular lipotoxicity","event_type":"KeyEvent"},{"event_id":177,"event":"Increase, Mitochondrial dysfunction","event_type":"KeyEvent"},{"event_id":55,"event":"Increase, Cell injury/death","event_type":"KeyEvent"},{"event_id":134,"event":"Increase, Kupffer cell activation","event_type":"KeyEvent"},{"event_id":1271,"event":"Increase, Transforming growth factor-beta signaling","event_type":"KeyEvent"},{"event_id":265,"event":"Increase, Hepatic stellate cell activation","event_type":"KeyEvent"},{"event_id":68,"event":"Increase, Collagen accumulation","event_type":"KeyEvent"},{"event_id":2406,"event":"Increase, Regenerative nodule formation","event_type":"KeyEvent"}],"aop_aos":[{"event_id":459,"event":"Increase, Liver steatosis","event_type":"AdverseOutcome"},{"event_id":1489,"event":"Increase, Steatohepatitis","event_type":"AdverseOutcome"},{"event_id":344,"event":"Increase, Liver fibrosis","event_type":"AdverseOutcome"},{"event_id":2407,"event":"Increase, Cirrhosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":4788,"upstream_event_id":2410,"upstream_event":"Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity ","downstream_event_id":2412,"downstream_event":"Increase, Hepatic intracellular active glucocorticoids"},{"relation":4789,"upstream_event_id":2412,"upstream_event":"Increase, Hepatic intracellular active glucocorticoids","downstream_event_id":122,"downstream_event":"Increase, Glucocorticoid receptor activation"},{"relation":4790,"upstream_event_id":122,"upstream_event":"Increase, Glucocorticoid receptor activation","downstream_event_id":2119,"downstream_event":"Increase, Insulin resistance"},{"relation":4791,"upstream_event_id":2119,"upstream_event":"Increase, Insulin resistance","downstream_event_id":2408,"downstream_event":"Increase, Adipose lipolysis"},{"relation":4792,"upstream_event_id":2408,"upstream_event":"Increase, Adipose lipolysis","downstream_event_id":465,"downstream_event":"Increased, Fatty acid influx"},{"relation":4793,"upstream_event_id":465,"upstream_event":"Increased, Fatty acid influx","downstream_event_id":459,"downstream_event":"Increase, Liver steatosis"},{"relation":4794,"upstream_event_id":459,"upstream_event":"Increase, Liver steatosis","downstream_event_id":2405,"downstream_event":"Increase, Hepatocellular lipotoxicity"},{"relation":4795,"upstream_event_id":177,"upstream_event":"Increase, Mitochondrial dysfunction","downstream_event_id":55,"downstream_event":"Increase, Cell injury/death"},{"relation":4796,"upstream_event_id":55,"upstream_event":"Increase, Cell injury/death","downstream_event_id":134,"downstream_event":"Increase, Kupffer cell activation"},{"relation":4797,"upstream_event_id":134,"upstream_event":"Increase, Kupffer cell activation","downstream_event_id":1489,"downstream_event":"Increase, Steatohepatitis"},{"relation":4798,"upstream_event_id":1489,"upstream_event":"Increase, Steatohepatitis","downstream_event_id":1271,"downstream_event":"Increase, Transforming growth factor-beta signaling"},{"relation":4799,"upstream_event_id":1271,"upstream_event":"Increase, Transforming growth factor-beta signaling","downstream_event_id":265,"downstream_event":"Increase, Hepatic stellate cell activation"},{"relation":4800,"upstream_event_id":265,"upstream_event":"Increase, Hepatic stellate cell activation","downstream_event_id":68,"downstream_event":"Increase, Collagen accumulation"},{"relation":4801,"upstream_event_id":68,"upstream_event":"Increase, Collagen accumulation","downstream_event_id":344,"downstream_event":"Increase, Liver fibrosis"},{"relation":4802,"upstream_event_id":344,"upstream_event":"Increase, Liver fibrosis","downstream_event_id":2406,"downstream_event":"Increase, Regenerative nodule formation"},{"relation":4803,"upstream_event_id":2406,"upstream_event":"Increase, Regenerative nodule formation","downstream_event_id":2407,"downstream_event":"Increase, Cirrhosis"}]}