{"id":627,"title":"Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction","short_name":"Increased 11β-HSD1 leading to MASLD via DNL-associated mitochondrial dysfunction","created_at":"2026-02-10T08:25:42.000-05:00","updated_at":"2026-06-26T16:12:16.000-04:00","corresponding_author":{"id":21137,"created_at":"2026-06-26T16:11:56.000-04:00","updated_at":"2026-06-26T16:11:56.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":2410,"event":"Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity ","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2412,"event":"Increase, Hepatic intracellular active glucocorticoids","event_type":"KeyEvent"},{"event_id":122,"event":"Increase, Glucocorticoid receptor activation","event_type":"KeyEvent"},{"event_id":1306,"event":"Increase, De novo lipogenesis","event_type":"KeyEvent"},{"event_id":2405,"event":"Increase, Hepatocellular lipotoxicity","event_type":"KeyEvent"},{"event_id":177,"event":"Increase, Mitochondrial dysfunction","event_type":"KeyEvent"},{"event_id":55,"event":"Increase, Cell injury/death","event_type":"KeyEvent"},{"event_id":134,"event":"Increase, Kupffer cell activation","event_type":"KeyEvent"},{"event_id":1271,"event":"Increase, Transforming growth factor-beta signaling","event_type":"KeyEvent"},{"event_id":265,"event":"Increase, Hepatic stellate cell activation","event_type":"KeyEvent"},{"event_id":68,"event":"Increase, Collagen accumulation","event_type":"KeyEvent"},{"event_id":2406,"event":"Increase, Regenerative nodule formation","event_type":"KeyEvent"}],"aop_aos":[{"event_id":459,"event":"Increase, Liver steatosis","event_type":"AdverseOutcome"},{"event_id":1489,"event":"Increase, Steatohepatitis","event_type":"AdverseOutcome"},{"event_id":344,"event":"Increase, Liver fibrosis","event_type":"AdverseOutcome"},{"event_id":2407,"event":"Increase, Cirrhosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":4838,"upstream_event_id":2410,"upstream_event":"Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity ","downstream_event_id":2412,"downstream_event":"Increase, Hepatic intracellular active glucocorticoids"},{"relation":4839,"upstream_event_id":2412,"upstream_event":"Increase, Hepatic intracellular active glucocorticoids","downstream_event_id":122,"downstream_event":"Increase, Glucocorticoid receptor activation"},{"relation":4840,"upstream_event_id":122,"upstream_event":"Increase, Glucocorticoid receptor activation","downstream_event_id":1306,"downstream_event":"Increase, De novo lipogenesis"},{"relation":4841,"upstream_event_id":1306,"upstream_event":"Increase, De novo lipogenesis","downstream_event_id":459,"downstream_event":"Increase, Liver steatosis"},{"relation":4842,"upstream_event_id":459,"upstream_event":"Increase, Liver steatosis","downstream_event_id":2405,"downstream_event":"Increase, Hepatocellular lipotoxicity"},{"relation":4843,"upstream_event_id":2405,"upstream_event":"Increase, Hepatocellular lipotoxicity","downstream_event_id":177,"downstream_event":"Increase, Mitochondrial dysfunction"},{"relation":4844,"upstream_event_id":55,"upstream_event":"Increase, Cell injury/death","downstream_event_id":134,"downstream_event":"Increase, Kupffer cell activation"},{"relation":4845,"upstream_event_id":134,"upstream_event":"Increase, Kupffer cell activation","downstream_event_id":1489,"downstream_event":"Increase, Steatohepatitis"},{"relation":4846,"upstream_event_id":1489,"upstream_event":"Increase, Steatohepatitis","downstream_event_id":1271,"downstream_event":"Increase, Transforming growth factor-beta signaling"},{"relation":4847,"upstream_event_id":1271,"upstream_event":"Increase, Transforming growth factor-beta signaling","downstream_event_id":265,"downstream_event":"Increase, Hepatic stellate cell activation"},{"relation":4848,"upstream_event_id":265,"upstream_event":"Increase, Hepatic stellate cell activation","downstream_event_id":68,"downstream_event":"Increase, Collagen accumulation"},{"relation":4849,"upstream_event_id":68,"upstream_event":"Increase, Collagen accumulation","downstream_event_id":344,"downstream_event":"Increase, Liver fibrosis"},{"relation":4850,"upstream_event_id":344,"upstream_event":"Increase, Liver fibrosis","downstream_event_id":2406,"downstream_event":"Increase, Regenerative nodule formation"},{"relation":4851,"upstream_event_id":2406,"upstream_event":"Increase, Regenerative nodule formation","downstream_event_id":2407,"downstream_event":"Increase, Cirrhosis"}]}