{"id":629,"title":"Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress","short_name":"Increased 11β-HSD1 leading to MASLD via DNL-associated ER stress","created_at":"2026-02-10T08:29:33.000-05:00","updated_at":"2026-06-26T16:12:16.000-04:00","corresponding_author":{"id":21139,"created_at":"2026-06-26T16:11:56.000-04:00","updated_at":"2026-06-26T17:14:26.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":2410,"event":"Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity ","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2412,"event":"Increase, Hepatic intracellular active glucocorticoids","event_type":"KeyEvent"},{"event_id":122,"event":"Increase, Glucocorticoid receptor activation","event_type":"KeyEvent"},{"event_id":1306,"event":"Increase, De novo lipogenesis","event_type":"KeyEvent"},{"event_id":2405,"event":"Increase, Hepatocellular lipotoxicity","event_type":"KeyEvent"},{"event_id":1815,"event":"Increase, Endoplasmic reticulum stress","event_type":"KeyEvent"},{"event_id":55,"event":"Increase, Cell injury/death","event_type":"KeyEvent"},{"event_id":134,"event":"Increase, Kupffer cell activation","event_type":"KeyEvent"},{"event_id":1271,"event":"Increase, Transforming growth factor-beta signaling","event_type":"KeyEvent"},{"event_id":265,"event":"Increase, Hepatic stellate cell activation","event_type":"KeyEvent"},{"event_id":68,"event":"Increase, Collagen accumulation","event_type":"KeyEvent"},{"event_id":2406,"event":"Increase, Regenerative nodule formation","event_type":"KeyEvent"}],"aop_aos":[{"event_id":459,"event":"Increase, Liver steatosis","event_type":"AdverseOutcome"},{"event_id":1489,"event":"Increase, Steatohepatitis","event_type":"AdverseOutcome"},{"event_id":344,"event":"Increase, Liver fibrosis","event_type":"AdverseOutcome"},{"event_id":2407,"event":"Increase, Cirrhosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":4867,"upstream_event_id":2410,"upstream_event":"Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity ","downstream_event_id":2412,"downstream_event":"Increase, Hepatic intracellular active glucocorticoids"},{"relation":4868,"upstream_event_id":2412,"upstream_event":"Increase, Hepatic intracellular active glucocorticoids","downstream_event_id":122,"downstream_event":"Increase, Glucocorticoid receptor activation"},{"relation":4869,"upstream_event_id":122,"upstream_event":"Increase, Glucocorticoid receptor activation","downstream_event_id":1306,"downstream_event":"Increase, De novo lipogenesis"},{"relation":4870,"upstream_event_id":1306,"upstream_event":"Increase, De novo lipogenesis","downstream_event_id":459,"downstream_event":"Increase, Liver steatosis"},{"relation":4871,"upstream_event_id":459,"upstream_event":"Increase, Liver steatosis","downstream_event_id":2405,"downstream_event":"Increase, Hepatocellular lipotoxicity"},{"relation":4872,"upstream_event_id":2405,"upstream_event":"Increase, Hepatocellular lipotoxicity","downstream_event_id":1815,"downstream_event":"Increase, Endoplasmic reticulum stress"},{"relation":4873,"upstream_event_id":1815,"upstream_event":"Increase, Endoplasmic reticulum stress","downstream_event_id":55,"downstream_event":"Increase, Cell injury/death"},{"relation":4874,"upstream_event_id":55,"upstream_event":"Increase, Cell injury/death","downstream_event_id":134,"downstream_event":"Increase, Kupffer cell activation"},{"relation":4875,"upstream_event_id":134,"upstream_event":"Increase, Kupffer cell activation","downstream_event_id":1489,"downstream_event":"Increase, Steatohepatitis"},{"relation":4876,"upstream_event_id":1489,"upstream_event":"Increase, Steatohepatitis","downstream_event_id":1271,"downstream_event":"Increase, Transforming growth factor-beta signaling"},{"relation":4877,"upstream_event_id":1271,"upstream_event":"Increase, Transforming growth factor-beta signaling","downstream_event_id":265,"downstream_event":"Increase, Hepatic stellate cell activation"},{"relation":4878,"upstream_event_id":265,"upstream_event":"Increase, Hepatic stellate cell activation","downstream_event_id":68,"downstream_event":"Increase, Collagen accumulation"},{"relation":4879,"upstream_event_id":68,"upstream_event":"Increase, Collagen accumulation","downstream_event_id":344,"downstream_event":"Increase, Liver fibrosis"},{"relation":4880,"upstream_event_id":344,"upstream_event":"Increase, Liver fibrosis","downstream_event_id":2406,"downstream_event":"Increase, Regenerative nodule formation"},{"relation":4881,"upstream_event_id":2406,"upstream_event":"Increase, Regenerative nodule formation","downstream_event_id":2407,"downstream_event":"Increase, Cirrhosis"}]}