{"id":8,"title":"Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals","short_name":"Nuclear receptor induced TH Catabolism and Developmental Hearing Loss","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2026-06-26T16:11:57.000-04:00","corresponding_author":{"id":21136,"created_at":"2026-06-26T16:11:56.000-04:00","updated_at":"2026-06-26T16:11:56.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":239,"event":"Activation, Pregnane-X receptor, NR1I2","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":295,"event":"Induction, Upregulation of glucuronyltransferase activity","event_type":"KeyEvent"},{"event_id":961,"event":"Increased, Clearance of thyroxine from serum","event_type":"KeyEvent"},{"event_id":281,"event":" Thyroxine (T4) in serum, Decreased","event_type":"KeyEvent"},{"event_id":280,"event":"Thyroxine (T4) in neuronal tissue, Decreased ","event_type":"KeyEvent"},{"event_id":756,"event":"Hippocampal gene expression, Altered ","event_type":"KeyEvent"},{"event_id":757,"event":"Hippocampal anatomy, Altered ","event_type":"KeyEvent"},{"event_id":758,"event":"Hippocampal Physiology, Altered","event_type":"KeyEvent"}],"aop_aos":[{"event_id":319,"event":"Loss, Cochlear function","event_type":"AdverseOutcome"}],"relationships":[{"relation":2830,"upstream_event_id":239,"upstream_event":"Activation, Pregnane-X receptor, NR1I2","downstream_event_id":295,"downstream_event":"Induction, Upregulation of glucuronyltransferase activity"},{"relation":2834,"upstream_event_id":295,"upstream_event":"Induction, Upregulation of glucuronyltransferase activity","downstream_event_id":961,"downstream_event":"Increased, Clearance of thyroxine from serum"},{"relation":2835,"upstream_event_id":961,"upstream_event":"Increased, Clearance of thyroxine from serum","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":2832,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":280,"downstream_event":"Thyroxine (T4) in neuronal tissue, Decreased "},{"relation":2833,"upstream_event_id":280,"upstream_event":"Thyroxine (T4) in neuronal tissue, Decreased ","downstream_event_id":756,"downstream_event":"Hippocampal gene expression, Altered "},{"relation":2836,"upstream_event_id":756,"upstream_event":"Hippocampal gene expression, Altered ","downstream_event_id":757,"downstream_event":"Hippocampal anatomy, Altered "},{"relation":2837,"upstream_event_id":757,"upstream_event":"Hippocampal anatomy, Altered ","downstream_event_id":758,"downstream_event":"Hippocampal Physiology, Altered"},{"relation":2838,"upstream_event_id":758,"upstream_event":"Hippocampal Physiology, Altered","downstream_event_id":319,"downstream_event":"Loss, Cochlear function"}]}