{"id":10,"title":"AOPs covering heart","purpose":"Collect AOPs associated with the heart and cardiovascular system","creation_strategy":"All AOPs that have \"heart failure\" in the title but are not in the OECD AOP Programme - see notes for details.\r\n","creation_strategy_notes":"- Search for \"heart\", review... then search for \"heart failure\"\r\n- Add all AOPs that have \"heart failure\" in the title\r\n- Remove the AOPs that had \"Under Development\" as the OECD Status","collection_type":"aop","status":"draft","creator_id":20133,"submitted_at":null,"approved_at":null,"rejected_at":null,"contributors":[],"item_count":8,"items":[{"id":427,"title":"ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure."},{"id":539,"title":"Decreased Sodium/Potassium ATPase activity leads to Heart failure"},{"id":550,"title":"Increased LMNA gene mutation leading to heart failure"},{"id":552,"title":"Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)"},{"id":553,"title":"Inhibition of Voltage-gated sodium channels (Na⁺ channels)  leading to heart failure"},{"id":555,"title":"Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure"},{"id":556,"title":"Decreased Na/K ATPase activity leading to heart failure"},{"id":558,"title":"Phosphodiesterase inhibition leading to heart failure"}]}