{"id":15,"title":"Immunotoxicity AOPs","purpose":"AOPs related to an adverse alteration of immune system function or integrity caused by a stressor, resulting in impaired immune defense, inappropriate immune activation, hypersensitivity, autoimmunity, or disrupted immune development.","creation_strategy":"Manual inspection of AOs and AOP titles for:\r\n* Immunosuppression\r\n* Immune hyperactivation\r\n* Increased disease susceptibility\r\n* Hypersensitivity\r\n* Autoimmunity\r\n* Developmental immunotoxicity","creation_strategy_notes":"","collection_type":"aop","status":"submitted","creator_id":13469,"submitted_at":"2026-08-10T13:45:41.000-04:00","approved_at":null,"rejected_at":null,"contributors":[],"item_count":20,"items":[{"id":14,"title":"Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility"},{"id":154,"title":"Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response"},{"id":277,"title":"Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response"},{"id":282,"title":"Adverse outcome pathway on photochemical toxicity initiated by light exposure"},{"id":313,"title":"Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease"},{"id":314,"title":"Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)"},{"id":315,"title":"Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response"},{"id":362,"title":"Immune mediated hepatitis"},{"id":377,"title":"Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)"},{"id":378,"title":"Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load"},{"id":392,"title":"Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation"},{"id":406,"title":"SARS-CoV-2 infection leading to hyperinflammation"},{"id":407,"title":"SARS-CoV-2 infection leading to pyroptosis"},{"id":412,"title":"Endothelial cell dysfunction leading to thromboinflammation"},{"id":430,"title":"Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation"},{"id":468,"title":"Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)"},{"id":506,"title":"Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation"},{"id":524,"title":"Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals "},{"id":578,"title":"AhR activation leading to cancer progression via immunosuppression"},{"id":618,"title":"PPARgamma activation leads to a diminished vaccine response"}]}