{"id":3,"title":"BY-SA Liver AOPs outside the OECD AOP Programme ","purpose":null,"creation_strategy":null,"creation_strategy_notes":null,"collection_type":"aop","status":"draft","creator_id":20133,"submitted_at":null,"approved_at":null,"rejected_at":null,"contributors":[],"item_count":16,"items":[{"id":1,"title":"Uncharacterized liver damage leading to hepatocellular carcinoma"},{"id":32,"title":"Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors"},{"id":240,"title":"DNA Adducts Leading to Liver Hemangiosarcoma"},{"id":273,"title":"Mitochondrial complex inhibition leading to liver injury"},{"id":278,"title":"IKK complex inhibition leading to liver injury"},{"id":285,"title":"Inhibition of N-linked glycosylation leads to liver injury"},{"id":454,"title":"PM2.5-related AOP frameworks on liver diseases"},{"id":494,"title":"AhR activation leading to liver fibrosis "},{"id":514,"title":"PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV "},{"id":517,"title":"Pregnane X Receptor (PXR) activation leads to liver steatosis"},{"id":518,"title":"Liver X Receptor (LXR) activation leads to liver steatosis"},{"id":529,"title":"Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis"},{"id":537,"title":"Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver"},{"id":591,"title":"DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration"},{"id":638,"title":"Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis"},{"id":642,"title":"Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation"}]}