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Showing 1 to 25 of 548 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Cataia Ives BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 896: Parkinsonian motor deficits WPHA/WNT Endorsed 1.33
4 Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 Brendan Ferreri-Hanberry BY-SA 103: Increase, Ecdysone receptor hyperactivation
6 Antagonist binding to PPARα leading to body-weight loss Agnes Aggy BY-SA 998: Binding of antagonist, PPAR alpha 864: Decreased, Body Weight WPHA/WNT Endorsed 2.3
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Allie Always BY-SA 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Under Review 1.21
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Cataia Ives BY-SA 667: Binding at picrotoxin site, iGABAR chloride channel 613: Occurrence, Epileptic seizure WPHA/WNT Endorsed 1.15
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Brendan Ferreri-Hanberry BY-SA 245: Activation, PXR/SXR None Under Development 2.5
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Arthur Author BY-SA 201: Binding of antagonist, NMDA receptors WPHA/WNT Endorsed 1.13
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Agnes Aggy BY-SA 201: Binding of antagonist, NMDA receptors 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.22
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Allie Always BY-SA 122: Activation, Glucocorticoid Receptor 323: Increased, Disease susceptibility
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Evgeniia Kazymova BY-SA 97: Alkylation, DNA 336: Increase, Heritable mutations in offspring WPHA/WNT Endorsed 1.11
16 Acetylcholinesterase inhibition leading to acute mortality Ginnie Hench BY-SA 12: Acetylcholinesterase (AchE) Inhibition Under Development 1.3
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Brendan Ferreri-Hanberry BY-SA 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.13
18 PPARα activation in utero leading to impaired fertility in males Arthur Author BY-SA 227: Activation, PPARα Under Review 1.21
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Agnes Aggy Open for adoption 26: Antagonism, Androgen receptor 337: N/A, Impairment of reproductive capacity
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Allie Always BY-SA 18: Activation, AhR None WPHA/WNT Endorsed 1.27
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Evgeniia Kazymova BY-SA 25: Agonism, Androgen receptor 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
25 Aromatase inhibition leading to reproductive dysfunction Cataia Ives BY-SA 36: Inhibition, Aromatase 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
26 Calcium-mediated neuronal ROS production and energy imbalance Brendan Ferreri-Hanberry Open for adoption 51: Inhibition, Ca++ ATPase 1392: Oxidative Stress
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Arthur Author BY-SA 41: Inhibition, Bile Salt Export Pump (ABCB11) 357: Cholestasis, Pathology Under Development 1.19
28 Cyclooxygenase inhibition leading reproductive failure Agnes Aggy BY-SA 79: Inhibition, Cyclooxygenase activity 253: N/A, Reproductive failure
29 Estrogen receptor agonism leading to reproductive dysfunction Allie Always BY-SA 111: Agonism, Estrogen receptor
30 Estrogen receptor antagonism leading to reproductive dysfunction Evgeniia Kazymova BY-SA 112: Antagonism, Estrogen receptor 360: Decrease, Population growth rate Under Review 1.12
31 Oxidation of iron in hemoglobin leading to hematotoxicity Cataia Ives Open for adoption 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) 321: N/A, Cyanosis occurs Under Development 1.16
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Brendan Ferreri-Hanberry BY-SA None None
33 Kidney toxicity induced by activation of 5HT2C Arthur Author Open for adoption 9: Activation, 5HT2c 759: Increased, Kidney Failure