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  • <h1>SNAPSHOT</h1>
  • <h4>Created at: 2019-01-04 09:03</h4>
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  • <!-- Title Section, includes id, name and short name -->
  • <div id="title">
  • <h2>AOP ID and Title:</h2>
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  • <div class="title">
  • AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
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  • <div class="title">AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters</div>
  • <strong>Short Title: PPARgamma-related sarcomas</strong>
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  • <!-- Author section, includes text of author names as they have been entered by the user -->
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  • <h2>Authors</h2>
  • <hr>
  • <p>Cancer AOP Workgroup. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)
  • </p>
  • <p>Cancer AOP Workgroup. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)</p>
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  • <!-- Status Section, lists status of aop -->
  • <div id="status">
  • <h2>Status</h2>
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  • <table class="table table-bordered table-striped">
  • <thead>
  • <th>Author status</th>
  • <th>OECD status</th>
  • <th>OECD project</th>
  • <th>SAAOP status</th>
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  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Author status</th>
  • <th scope="col">OECD status</th>
  • <th scope="col">OECD project</th>
  • <th scope="col">SAAOP status</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>Under development: Not open for comment. Do not cite</td>
  • <td>Under Development: Contributions and Comments Welcome</td>
  • <td></td>
  • <td></td>
  • <td>1.29</td>
  • <td>Under Development</td>
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  • <!-- Abstract Section, text as generated by author -->
  • <div id="abstract">
  • <h2>Abstract</h2>
  • <p>This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.</p>
  • <p>&nbsp;</p>
  • <h2>Abstract</h2>
  • <hr>
  • <p>This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.
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  • <!-- Background Section, text as generated by author -->
  • <div id="background">
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  • </div>
  • <!-- AOP summary, includes summary of each of the events associated with this aop -->
  • <div id="aop_summary">
  • <h2>Summary of the AOP</h2>
  • <!-- event table -->
  • <h3>Events</h3>
  • <h3>Molecular Initiating Events (MIE), Key Events (KE), Adverse Outcomes (AO)</h3>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Sequence</th>
  • <th>Type</th>
  • <th>Event ID</th>
  • <th>Title</th>
  • <th>Short name</th>
  • <h3>Molecular Initiating Events (MIE), Key Events (KE), Adverse Outcomes (AO)</h3>
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  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Sequence</th>
  • <th scope="col">Type</th>
  • <th scope="col">Event ID</th>
  • <th scope="col">Title</th>
  • <th scope="col">Short name</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>1</td>
  • <td>MIE</td>
  • <td>1028</td>
  • <td><a href="/events/1028">Activation of specific nuclear receptors, PPAR-gamma activation</a></td>
  • <td>Activation of specific nuclear receptors, PPAR-gamma activation</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>1</td>
  • <td>MIE</td>
  • <td>1028</td>
  • <td><a href="/events/1028">Activation of specific nuclear receptors, PPAR-gamma activation</a></td>
  • <td>Activation of specific nuclear receptors, PPAR-gamma activation</td>
  • </tr>
  • <tr><td></td><td></td><td></td><td></td><td></td></tr>
  • <tr>
  • <td>2</td>
  • <td>KE</td>
  • <td>1029</td>
  • <td><a href="/events/1029">Increased, adipogenesis</a></td>
  • <td>Increased, adipogenesis</td>
  • </tr>
  • <tr>
  • <td>3</td>
  • <td>KE</td>
  • <td>1032</td>
  • <td><a href="/events/1032">Increased, secretion of local growth factors</a></td>
  • <td>Increased, secretion of local growth factors</td>
  • </tr>
  • <tr>
  • <td>4</td>
  • <td>KE</td>
  • <td>1033</td>
  • <td><a href="/events/1033">Increased, proliferation of mesenchymal cells</a></td>
  • <td>Increased, proliferation of mesenchymal cells</td>
  • </tr>
  • <tr>
  • <td>5</td>
  • <td>KE</td>
  • <td>1034</td>
  • <td><a href="/events/1034">Increased, IGF-1 (mouse)</a></td>
  • <td>Increased, IGF-1 (mouse)</td>
  • </tr>
  • <tr>
  • <td>6</td>
  • <td>KE</td>
  • <td>1035</td>
  • <td><a href="/events/1035">Increased, Firbrosarcoma</a></td>
  • <td>Increased, Firbrosarcoma</td>
  • </tr>
  • <tr>
  • <td>7</td>
  • <td>KE</td>
  • <td>1036</td>
  • <td><a href="/events/1036">Increased, liposarcoma</a></td>
  • <td>Increased, liposarcoma</td>
  • </tr>
  • <tr>
  • <td>8</td>
  • <td>KE</td>
  • <td>1037</td>
  • <td><a href="/events/1037">Increased, hemagiosarcoma</a></td>
  • <td>Increased, hemagiosarcoma</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <tr><td></td><td></td><td></td><td></td><td></td></tr>
  • <tr>
  • <td>2</td>
  • <td>KE</td>
  • <td>1029</td>
  • <td><a href="/events/1029">Increased, adipogenesis</a></td>
  • <td>Increased, adipogenesis</td>
  • </tr>
  • <tr>
  • <td>3</td>
  • <td>KE</td>
  • <td>1032</td>
  • <td><a href="/events/1032">Increased, secretion of local growth factors</a></td>
  • <td>Increased, secretion of local growth factors</td>
  • </tr>
  • <tr>
  • <td>4</td>
  • <td>KE</td>
  • <td>1033</td>
  • <td><a href="/events/1033">Increased, proliferation of mesenchymal cells</a></td>
  • <td>Increased, proliferation of mesenchymal cells</td>
  • </tr>
  • <tr>
  • <td>5</td>
  • <td>KE</td>
  • <td>1034</td>
  • <td><a href="/events/1034">Increased, IGF-1 (mouse)</a></td>
  • <td>Increased, IGF-1 (mouse)</td>
  • </tr>
  • <tr>
  • <td>6</td>
  • <td>KE</td>
  • <td>1035</td>
  • <td><a href="/events/1035">Increased, Firbrosarcoma</a></td>
  • <td>Increased, Firbrosarcoma</td>
  • </tr>
  • <tr>
  • <td>7</td>
  • <td>KE</td>
  • <td>1036</td>
  • <td><a href="/events/1036">Increased, liposarcoma</a></td>
  • <td>Increased, liposarcoma</td>
  • </tr>
  • <tr>
  • <td>8</td>
  • <td>KE</td>
  • <td>1037</td>
  • <td><a href="/events/1037">Increased, hemagiosarcoma</a></td>
  • <td>Increased, hemagiosarcoma</td>
  • </tr>
  • </tbody>
  • </table>
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  • <!-- rel table -->
  • <h3>Key Event Relationships</h3>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Upstream Event</th>
  • <th>Relationship Type</th>
  • <th>Downstream Event</th>
  • <th>Evidence</th>
  • <th>Quantitative Understanding</th>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Upstream Event</th>
  • <th scope="col">Relationship Type</th>
  • <th scope="col">Downstream Event</th>
  • <th scope="col">Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/relationships/1073">Increased, adipogenesis</a></td>
  • <td>adjacent</td>
  • <td>Increased, secretion of local growth factors</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/relationships/1073">Increased, adipogenesis</a></td>
  • <td>adjacent</td>
  • <td>Increased, secretion of local growth factors</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1074">Increased, secretion of local growth factors</a></td>
  • <td>adjacent</td>
  • <td>Increased, proliferation of mesenchymal cells</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1075">Increased, secretion of local growth factors</a></td>
  • <td>adjacent</td>
  • <td>Increased, IGF-1 (mouse)</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1076">Increased, proliferation of mesenchymal cells</a></td>
  • <td>adjacent</td>
  • <td>Increased, Firbrosarcoma</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1077">Increased, proliferation of mesenchymal cells</a></td>
  • <td>adjacent</td>
  • <td>Increased, liposarcoma</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1078">Increased, proliferation of mesenchymal cells</a></td>
  • <td>adjacent</td>
  • <td>Increased, hemagiosarcoma</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • <tr><td></td><td></td><td></td><td></td><td></td></tr>
  • <tr>
  • <td><a href="/relationships/1071">Activation of specific nuclear receptors, PPAR-gamma activation</a></td>
  • <td>non-adjacent</td>
  • <td>Increased, adipogenesis</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1072">Activation of specific nuclear receptors, PPAR-gamma activation</a></td>
  • <td>non-adjacent</td>
  • <td>Increased, secretion of local growth factors</td>
  • <td>Moderate</td>
  • <td></td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- stressor table -->
  • <h3>Stressors</h3>
  • <br>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Name</th>
  • <th>Evidence</th>
  • <td><a href="/relationships/1074">Increased, secretion of local growth factors</a></td>
  • <td>adjacent</td>
  • <td>Increased, proliferation of mesenchymal cells</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Troglitazone</td>
  • <td></td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <tr>
  • <td><a href="/relationships/1075">Increased, secretion of local growth factors</a></td>
  • <td>adjacent</td>
  • <td>Increased, IGF-1 (mouse)</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1076">Increased, proliferation of mesenchymal cells</a></td>
  • <td>adjacent</td>
  • <td>Increased, Firbrosarcoma</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1077">Increased, proliferation of mesenchymal cells</a></td>
  • <td>adjacent</td>
  • <td>Increased, liposarcoma</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1078">Increased, proliferation of mesenchymal cells</a></td>
  • <td>adjacent</td>
  • <td>Increased, hemagiosarcoma</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • <tr>
  • <td></td>
  • <td></td>
  • <td></td>
  • <td></td>
  • <td></td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1071">Activation of specific nuclear receptors, PPAR-gamma activation</a></td>
  • <td>non-adjacent</td>
  • <td>Increased, adipogenesis</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1072">Activation of specific nuclear receptors, PPAR-gamma activation</a></td>
  • <td>non-adjacent</td>
  • <td>Increased, secretion of local growth factors</td>
  • <td>Moderate</td>
  • <td></td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <h3>Stressors</h3>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Name</th>
  • <th scope="col">Evidence</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>Troglitazone</td>
  • <td></td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end summary -->
  • <!-- Overall assessment section, *** what is included here? *** -->
  • <div id="overall_assessment">
  • <h2>Overall Assessment of the AOP</h2>
  • <hr>
  • <h3>Domain of Applicability</h3>
  • <strong>Taxonomic Applicability</strong>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <h3>Domain of Applicability</h3>
  • <strong>Taxonomic Applicability</strong>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th>Term</th>
  • <th>Scientific Term</th>
  • <th>Evidence</th>
  • <th>Links</th>
  • <th scope="col">Term</th>
  • <th scope="col">Scientific Term</th>
  • <th scope="col">Evidence</th>
  • <th scope="col">Links</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Rattus rattus</td>
  • <td>Rattus rattus</td>
  • <td>High</td>
  • <td>
  • <a href="http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=10117" , target="_blank">NCBI</a>
  • </td>
  • </tr>
  • <tr>
  • <td>mouse</td>
  • <td>Mus musculus</td>
  • <td>Moderate</td>
  • <td>
  • <a href="http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=10090" , target="_blank">NCBI</a>
  • </td>
  • </tr>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>Rattus rattus</td>
  • <td>Rattus rattus</td>
  • <td>High</td>
  • <td><a href="http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=10117" target="_blank">NCBI</a></td>
  • </tr>
  • <tr>
  • <td>mouse</td>
  • <td>Mus musculus</td>
  • <td>Moderate</td>
  • <td><a href="http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=10090" target="_blank">NCBI</a></td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- potential consierations, text as entered by author -->
  • <div id="considerations_for_potential_applicaitons">
  • </div>
  • <!-- reference section, text as of right now but should be changed to be handled as table -->
  • <div id="references">
  • <h2>References</h2>
  • <hr>
  • <p>1. Cohen, S. M. (2005). Effects of PPARgamma and combined agonists on the urinary tract of rats and other species. Toxicological sciences&#160;: an official journal of the Society of Toxicology 87(2), 322-7, 10.1093/toxsci/kfi266.
  • </p><p>2. Hardisty, J. F., Elwell, M. R., Ernst, H., Greaves, P., Kolenda-Roberts, H., Malarkey, D. E., Mann, P. C., and Tellier, P. A. (2007). Histopathology of hemangiosarcomas in mice and hamsters and liposarcomas/fibrosarcomas in rats associated with PPAR agonists. Toxicologic pathology 35(7), 928-41, 10.1080/01926230701748156.
  • </p><p>3. Kakiuchi-Kiyota, S., Arnold, L. L., Yokohira, M., Koza-Taylor, P., Suzuki, S., Varney, M., Pennington, K. L., and Cohen, S. M. (2011a). Evaluation of direct and indirect effects of the PPARgamma agonist troglitazone on mouse endothelial cell proliferation. Toxicologic pathology 39(7), 1032-45, 10.1177/0192623311422080.
  • </p><p>4. Kakiuchi-Kiyota, S., Arnold, L. L., Yokohira, M., Suzuki, S., Pennington, K. L., and Cohen, S. M. (2011b). Evaluation of PPARgamma agonists on rodent endothelial cell proliferation. Toxicology 287(1-3), 91-8, 10.1016/j.tox.2011.05.019.
  • </p><p>5. Long, G. G., Reynolds, V. L., Dochterman, L. W., and Ryan, T. E. (2009). Neoplastic and non-neoplastic changes in F-344 rats treated with Naveglitazar, a gamma-dominant PPAR alpha/gamma agonist. Toxicologic pathology 37(6), 741-53, 10.1177/0192623309343775.
  • </p><p><br />
  • </p>
  • <br>
  • <p>1. Cohen, S. M. (2005). Effects of PPARgamma and combined agonists on the urinary tract of rats and other species. Toxicological sciences&nbsp;: an official journal of the Society of Toxicology 87(2), 322-7, 10.1093/toxsci/kfi266.</p>
  • <p>2. Hardisty, J. F., Elwell, M. R., Ernst, H., Greaves, P., Kolenda-Roberts, H., Malarkey, D. E., Mann, P. C., and Tellier, P. A. (2007). Histopathology of hemangiosarcomas in mice and hamsters and liposarcomas/fibrosarcomas in rats associated with PPAR agonists. Toxicologic pathology 35(7), 928-41, 10.1080/01926230701748156.</p>
  • <p>3. Kakiuchi-Kiyota, S., Arnold, L. L., Yokohira, M., Koza-Taylor, P., Suzuki, S., Varney, M., Pennington, K. L., and Cohen, S. M. (2011a). Evaluation of direct and indirect effects of the PPARgamma agonist troglitazone on mouse endothelial cell proliferation. Toxicologic pathology 39(7), 1032-45, 10.1177/0192623311422080.</p>
  • <p>4. Kakiuchi-Kiyota, S., Arnold, L. L., Yokohira, M., Suzuki, S., Pennington, K. L., and Cohen, S. M. (2011b). Evaluation of PPARgamma agonists on rodent endothelial cell proliferation. Toxicology 287(1-3), 91-8, 10.1016/j.tox.2011.05.019.</p>
  • <p>5. Long, G. G., Reynolds, V. L., Dochterman, L. W., and Ryan, T. E. (2009). Neoplastic and non-neoplastic changes in F-344 rats treated with Naveglitazar, a gamma-dominant PPAR alpha/gamma agonist. Toxicologic pathology 37(6), 741-53, 10.1177/0192623309343775.</p>
  • <p>&nbsp;</p>
  • </div>
  • <div id="appendicies">
  • <h2>Appendix 1</h2>
  • <h3>List of MIEs in this AOP</h3>
  • <div>
  • <div>
  • <h4><a href="/events/1028">Event: 1028: Activation of specific nuclear receptors, PPAR-gamma activation</a><br></h4>
  • <h5>Short Name: Activation of specific nuclear receptors, PPAR-gamma activation</h5>
  • </div>
  • <h4>Key Event Component</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Process</th>
  • <th>Object</th>
  • <th>Action</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>peroxisome proliferator activated receptor signaling pathway</td>
  • <td>peroxisome proliferator-activated receptor gamma</td>
  • <td>decreased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <!-- loop to find all aops that use this event -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <h4><a href="/events/1028">Event: 1028: Activation of specific nuclear receptors, PPAR-gamma activation</a></h4>
  • <h5>Short Name: Activation of specific nuclear receptors, PPAR-gamma activation</h5>
  • <h4>Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP ID and Name</th>
  • <th>Event Type</th>
  • <td>peroxisome proliferator activated receptor signaling pathway</td>
  • <td>peroxisome proliferator-activated receptor gamma</td>
  • <td>decreased</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>MolecularInitiatingEvent</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/72">Aop:72 - Epigenetic modification of PPARG leading to adipogenesis</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- loop to find stressors under event -->
  • <div>
  • <h4>Stressors</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Name</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Tetrabromobisphenol A</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </tbody>
  • </table>
  • </div>
  • <br>
  • <!-- biological organization -->
  • <div>
  • <h4>Biological Context</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Level of Biological Organization</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Molecular</td>
  • </tr>
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>MolecularInitiatingEvent</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/72">Aop:72 - Epigenetic modification of PPARG leading to adipogenesis</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </tbody>
  • </table>
  • </div>
  • <h4>Stressors</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Name</th></tr>
  • </thead>
  • <tbody>
  • <tr><td>Tetrabromobisphenol A</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- end of bio org -->
  • <!-- cell term -->
  • <div>
  • <h4>Cell term</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Cell term</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>hepatocyte</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Molecular</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- end of cell term -->
  • <!-- organ term -->
  • <div>
  • <h4>Cell term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Cell term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>hepatocyte</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- end of organ term -->
  • <!-- Evidence for Perturbation of This Event by Stressors -->
  • <h3>Evidence for Perturbation by Stressor</h3>
  • <hr>
  • <br>
  • <br>
  • <h4>Tetrabromobisphenol A</h4>
  • <p><p style="margin-left:24.0pt">TBBPA binds to PPAR&gamma; <em>in vitro</em>, with a Kd of 0.78 &micro;M and <em>in vivo </em>in zebrafish, with a LOEL of 100 nM &nbsp;(Fang et al., 2015; Riu et al., 2011; Riu et al., 2014). Mild activation has also been reported <em>in vitro </em>in several research papers and in ToxCast assays as well, with effective doses ranging from 0.3 to 10 &micro;M (Riu et al., 2011; Riu et al., 2014; Suzuki et al., 2013; ToxCastTM Data; Watt and Schlezinger, 2015).</p>
  • </p>
  • <br>
  • <!-- end Evidence for Perturbation of This Event by Stressors -->
  • <!-- event text -->
  • <!-- end event text -->
  • </div>
  • <h3>List of Key Events in the AOP</h3>
  • <div>
  • <div>
  • <h4><a href="/events/1029">Event: 1029: Increased, adipogenesis</a><br></h4>
  • <h5>Short Name: Increased, adipogenesis</h5>
  • </div>
  • <h4>Key Event Component</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Process</th>
  • <th>Object</th>
  • <th>Action</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>fat cell differentiation</td>
  • <td></td>
  • <td>increased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <!-- loop to find all aops that use this event -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <h4><a href="/events/1029">Event: 1029: Increased, adipogenesis</a></h4>
  • <h5>Short Name: Increased, adipogenesis</h5>
  • <h4>Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP ID and Name</th>
  • <th>Event Type</th>
  • <td>fat cell differentiation</td>
  • <td></td>
  • <td>increased</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- loop to find stressors under event -->
  • <div>
  • </div>
  • <br>
  • <!-- biological organization -->
  • <div>
  • <h4>Biological Context</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Level of Biological Organization</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Cellular</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of bio org -->
  • <!-- cell term -->
  • <div>
  • <h4>Cell term</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Cell term</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>eukaryotic cell</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of cell term -->
  • <!-- organ term -->
  • <div>
  • </tbody>
  • </table>
  • </div>
  • <!-- end of organ term -->
  • <!-- Evidence for Perturbation of This Event by Stressors -->
  • <!-- end Evidence for Perturbation of This Event by Stressors -->
  • <!-- event text -->
  • <!-- end event text -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <div>
  • <h4><a href="/events/1032">Event: 1032: Increased, secretion of local growth factors</a><br></h4>
  • <h5>Short Name: Increased, secretion of local growth factors</h5>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Cellular</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Cell term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Cell term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>eukaryotic cell</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Key Event Component</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Process</th>
  • <th>Object</th>
  • <th>Action</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>secretion</td>
  • <td>eukaryotic protein</td>
  • <td>increased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <!-- loop to find all aops that use this event -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <h4><a href="/events/1032">Event: 1032: Increased, secretion of local growth factors</a></h4>
  • <h5>Short Name: Increased, secretion of local growth factors</h5>
  • <h4>Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP ID and Name</th>
  • <th>Event Type</th>
  • <td>secretion</td>
  • <td>eukaryotic protein</td>
  • <td>increased</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/171">Aop:171 - Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- loop to find stressors under event -->
  • <div>
  • </div>
  • <br>
  • <!-- biological organization -->
  • <div>
  • <h4>Biological Context</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Level of Biological Organization</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Cellular</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of bio org -->
  • <!-- cell term -->
  • <div>
  • <h4>Cell term</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Cell term</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>eukaryotic cell</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of cell term -->
  • <!-- organ term -->
  • <div>
  • </tbody>
  • </table>
  • </div>
  • <!-- end of organ term -->
  • <!-- Evidence for Perturbation of This Event by Stressors -->
  • <!-- end Evidence for Perturbation of This Event by Stressors -->
  • <!-- event text -->
  • <!-- end event text -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/171">Aop:171 - Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <div>
  • <h4><a href="/events/1033">Event: 1033: Increased, proliferation of mesenchymal cells</a><br></h4>
  • <h5>Short Name: Increased, proliferation of mesenchymal cells</h5>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Cellular</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Cell term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Cell term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>eukaryotic cell</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Key Event Component</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Process</th>
  • <th>Object</th>
  • <th>Action</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>mesenchymal cell proliferation</td>
  • <td>mesenchymal cell</td>
  • <td>increased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <!-- loop to find all aops that use this event -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <h4><a href="/events/1033">Event: 1033: Increased, proliferation of mesenchymal cells</a></h4>
  • <h5>Short Name: Increased, proliferation of mesenchymal cells</h5>
  • <h4>Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP ID and Name</th>
  • <th>Event Type</th>
  • <td>mesenchymal cell proliferation</td>
  • <td>mesenchymal cell</td>
  • <td>increased</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- loop to find stressors under event -->
  • <div>
  • </div>
  • <br>
  • <!-- biological organization -->
  • <div>
  • <h4>Biological Context</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Level of Biological Organization</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Cellular</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of bio org -->
  • <!-- cell term -->
  • <div>
  • <h4>Cell term</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Cell term</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>mesenchymal cell</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of cell term -->
  • <!-- organ term -->
  • <div>
  • </tbody>
  • </table>
  • </div>
  • <!-- end of organ term -->
  • <!-- Evidence for Perturbation of This Event by Stressors -->
  • <!-- end Evidence for Perturbation of This Event by Stressors -->
  • <!-- event text -->
  • <!-- end event text -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <div>
  • <h4><a href="/events/1034">Event: 1034: Increased, IGF-1 (mouse)</a><br></h4>
  • <h5>Short Name: Increased, IGF-1 (mouse)</h5>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Cellular</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Cell term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Cell term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>mesenchymal cell</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Key Event Component</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Process</th>
  • <th>Object</th>
  • <th>Action</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>gene expression</td>
  • <td>IGF-like family receptor 1 (mouse)</td>
  • <td>increased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <!-- loop to find all aops that use this event -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <h4><a href="/events/1034">Event: 1034: Increased, IGF-1 (mouse)</a></h4>
  • <h5>Short Name: Increased, IGF-1 (mouse)</h5>
  • <h4>Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP ID and Name</th>
  • <th>Event Type</th>
  • <td>gene expression</td>
  • <td>IGF-like family receptor 1 (mouse)</td>
  • <td>increased</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- loop to find stressors under event -->
  • <div>
  • </div>
  • <br>
  • <!-- biological organization -->
  • <div>
  • <h4>Biological Context</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Level of Biological Organization</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Cellular</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of bio org -->
  • <!-- cell term -->
  • <div>
  • <h4>Cell term</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Cell term</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>eukaryotic cell</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of cell term -->
  • <!-- organ term -->
  • <div>
  • </tbody>
  • </table>
  • </div>
  • <!-- end of organ term -->
  • <!-- Evidence for Perturbation of This Event by Stressors -->
  • <!-- end Evidence for Perturbation of This Event by Stressors -->
  • <!-- event text -->
  • <!-- end event text -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <div>
  • <h4><a href="/events/1035">Event: 1035: Increased, Firbrosarcoma</a><br></h4>
  • <h5>Short Name: Increased, Firbrosarcoma</h5>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Cellular</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Cell term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Cell term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>eukaryotic cell</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Key Event Component</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Process</th>
  • <th>Object</th>
  • <th>Action</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td></td>
  • <td>Fibrosarcoma</td>
  • <td>increased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <!-- loop to find all aops that use this event -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <h4><a href="/events/1035">Event: 1035: Increased, Firbrosarcoma</a></h4>
  • <h5>Short Name: Increased, Firbrosarcoma</h5>
  • <h4>Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP ID and Name</th>
  • <th>Event Type</th>
  • <td></td>
  • <td>Fibrosarcoma</td>
  • <td>increased</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- loop to find stressors under event -->
  • <div>
  • </div>
  • <br>
  • <!-- biological organization -->
  • <div>
  • <h4>Biological Context</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Level of Biological Organization</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Tissue</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of bio org -->
  • <!-- cell term -->
  • <div>
  • </div>
  • <!-- end of cell term -->
  • <!-- organ term -->
  • <div>
  • <h4>Organ term</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Organ term</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>fibrous connective tissue</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </tbody>
  • </table>
  • </div>
  • <!-- end of organ term -->
  • <!-- Evidence for Perturbation of This Event by Stressors -->
  • <!-- end Evidence for Perturbation of This Event by Stressors -->
  • <!-- event text -->
  • <!-- end event text -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <div>
  • <h4><a href="/events/1036">Event: 1036: Increased, liposarcoma</a><br></h4>
  • <h5>Short Name: Increased, liposarcoma</h5>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Tissue</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Organ term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Organ term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>fibrous connective tissue</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Key Event Component</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Process</th>
  • <th>Object</th>
  • <th>Action</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td></td>
  • <td>liposarcoma</td>
  • <td>increased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <!-- loop to find all aops that use this event -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <h4><a href="/events/1036">Event: 1036: Increased, liposarcoma</a></h4>
  • <h5>Short Name: Increased, liposarcoma</h5>
  • <h4>Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP ID and Name</th>
  • <th>Event Type</th>
  • <td></td>
  • <td>liposarcoma</td>
  • <td>increased</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- loop to find stressors under event -->
  • <div>
  • </div>
  • <br>
  • <!-- biological organization -->
  • <div>
  • <h4>Biological Context</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Level of Biological Organization</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Tissue</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of bio org -->
  • <!-- cell term -->
  • <div>
  • </div>
  • <!-- end of cell term -->
  • <!-- organ term -->
  • <div>
  • <h4>Organ term</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Organ term</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>adipose tissue</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </tbody>
  • </table>
  • </div>
  • <!-- end of organ term -->
  • <!-- Evidence for Perturbation of This Event by Stressors -->
  • <!-- end Evidence for Perturbation of This Event by Stressors -->
  • <!-- event text -->
  • <!-- end event text -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <div>
  • <h4><a href="/events/1037">Event: 1037: Increased, hemagiosarcoma</a><br></h4>
  • <h5>Short Name: Increased, hemagiosarcoma</h5>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Tissue</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Organ term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Organ term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>adipose tissue</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Key Event Component</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Process</th>
  • <th>Object</th>
  • <th>Action</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td></td>
  • <td>hemangiosarcoma</td>
  • <td>increased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <!-- loop to find all aops that use this event -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <h4><a href="/events/1037">Event: 1037: Increased, hemagiosarcoma</a></h4>
  • <h5>Short Name: Increased, hemagiosarcoma</h5>
  • <h4>Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP ID and Name</th>
  • <th>Event Type</th>
  • <td></td>
  • <td>hemangiosarcoma</td>
  • <td>increased</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- loop to find stressors under event -->
  • <div>
  • </tbody>
  • </table>
  • </div>
  • <br>
  • <!-- biological organization -->
  • <div>
  • <h4>Biological Context</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Level of Biological Organization</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Tissue</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of bio org -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/163">Aop:163 - PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- cell term -->
  • <div>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Tissue</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- end of cell term -->
  • <!-- organ term -->
  • <div>
  • <h4>Organ term</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Organ term</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>blood vessel endothelium</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Organ term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Organ term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>blood vessel endothelium</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- end of organ term -->
  • <!-- Evidence for Perturbation of This Event by Stressors -->
  • <!-- end Evidence for Perturbation of This Event by Stressors -->
  • <!-- event text -->
  • <!-- end event text -->
  • </div>
  • <h2>Appendix 2</h2>
  • <h2>List of Key Event Relationships in the AOP</h2>
  • <!-- Evidence for relationship links section, this lists the relationships and then supports them -->
  • <div id="evidence_supporting_links">
  • <hr>
  • <h3>List of Adjacent Key Event Relationships</h3>
  • <div>
  • <div id="evidence_supporting_links">
  • <h3>List of Adjacent Key Event Relationships</h3>
  • <div>
  • <h4><a href="/relationships/1073">Relationship: 1073: Increased, adipogenesis leads to Increased, secretion of local growth factors</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP Name</th>
  • <th>Adjacency</th>
  • <th>Weight of Evidence</th>
  • <th>Quantitative Understanding</th>
  • <td><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>adjacent</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <th><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></th>
  • <th>adjacent</th>
  • <th>High </th>
  • <th></th>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- if nothing shows up in any of these fields, then evidence supporting this KER will not be displayed -->
  • <!--<!% unless aop_rel.relationship.relationship_taxons.blank? %>-->
  • <!--<!%= render 'snapshot_taxons', taxons: aop_rel.relationship.relationship_taxons %>-->
  • <!--<!% unless aop_rel.relationship.taxon_evidence.blank? %>-->
  • <!--<h3>Domain of Applicability</h3>-->
  • <!--<!%== aop_rel.relationship.taxon_evidence %>-->
  • <!--<!% end %>-->
  • <!--<!% end %>-->
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <br>
  • <div>
  • <div>
  • <h4><a href="/relationships/1074">Relationship: 1074: Increased, secretion of local growth factors leads to Increased, proliferation of mesenchymal cells</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP Name</th>
  • <th>Adjacency</th>
  • <th>Weight of Evidence</th>
  • <th>Quantitative Understanding</th>
  • <td><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>adjacent</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <th><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></th>
  • <th>adjacent</th>
  • <th>High </th>
  • <th></th>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- if nothing shows up in any of these fields, then evidence supporting this KER will not be displayed -->
  • <!--<!% unless aop_rel.relationship.relationship_taxons.blank? %>-->
  • <!--<!%= render 'snapshot_taxons', taxons: aop_rel.relationship.relationship_taxons %>-->
  • <!--<!% unless aop_rel.relationship.taxon_evidence.blank? %>-->
  • <!--<h3>Domain of Applicability</h3>-->
  • <!--<!%== aop_rel.relationship.taxon_evidence %>-->
  • <!--<!% end %>-->
  • <!--<!% end %>-->
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <br>
  • <div>
  • <div>
  • <h4><a href="/relationships/1075">Relationship: 1075: Increased, secretion of local growth factors leads to Increased, IGF-1 (mouse)</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP Name</th>
  • <th>Adjacency</th>
  • <th>Weight of Evidence</th>
  • <th>Quantitative Understanding</th>
  • <td><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>adjacent</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <th><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></th>
  • <th>adjacent</th>
  • <th>High </th>
  • <th></th>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- if nothing shows up in any of these fields, then evidence supporting this KER will not be displayed -->
  • <!--<!% unless aop_rel.relationship.relationship_taxons.blank? %>-->
  • <!--<!%= render 'snapshot_taxons', taxons: aop_rel.relationship.relationship_taxons %>-->
  • <!--<!% unless aop_rel.relationship.taxon_evidence.blank? %>-->
  • <!--<h3>Domain of Applicability</h3>-->
  • <!--<!%== aop_rel.relationship.taxon_evidence %>-->
  • <!--<!% end %>-->
  • <!--<!% end %>-->
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <br>
  • <div>
  • <div>
  • <h4><a href="/relationships/1076">Relationship: 1076: Increased, proliferation of mesenchymal cells leads to Increased, Firbrosarcoma</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP Name</th>
  • <th>Adjacency</th>
  • <th>Weight of Evidence</th>
  • <th>Quantitative Understanding</th>
  • <td><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>adjacent</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <th><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></th>
  • <th>adjacent</th>
  • <th>High </th>
  • <th></th>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- if nothing shows up in any of these fields, then evidence supporting this KER will not be displayed -->
  • <!--<!% unless aop_rel.relationship.relationship_taxons.blank? %>-->
  • <!--<!%= render 'snapshot_taxons', taxons: aop_rel.relationship.relationship_taxons %>-->
  • <!--<!% unless aop_rel.relationship.taxon_evidence.blank? %>-->
  • <!--<h3>Domain of Applicability</h3>-->
  • <!--<!%== aop_rel.relationship.taxon_evidence %>-->
  • <!--<!% end %>-->
  • <!--<!% end %>-->
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <br>
  • <div>
  • <div>
  • <h4><a href="/relationships/1077">Relationship: 1077: Increased, proliferation of mesenchymal cells leads to Increased, liposarcoma</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP Name</th>
  • <th>Adjacency</th>
  • <th>Weight of Evidence</th>
  • <th>Quantitative Understanding</th>
  • <td><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>adjacent</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <th><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></th>
  • <th>adjacent</th>
  • <th>High </th>
  • <th></th>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- if nothing shows up in any of these fields, then evidence supporting this KER will not be displayed -->
  • <!--<!% unless aop_rel.relationship.relationship_taxons.blank? %>-->
  • <!--<!%= render 'snapshot_taxons', taxons: aop_rel.relationship.relationship_taxons %>-->
  • <!--<!% unless aop_rel.relationship.taxon_evidence.blank? %>-->
  • <!--<h3>Domain of Applicability</h3>-->
  • <!--<!%== aop_rel.relationship.taxon_evidence %>-->
  • <!--<!% end %>-->
  • <!--<!% end %>-->
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <br>
  • <div>
  • <div>
  • <h4><a href="/relationships/1078">Relationship: 1078: Increased, proliferation of mesenchymal cells leads to Increased, hemagiosarcoma</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP Name</th>
  • <th>Adjacency</th>
  • <th>Weight of Evidence</th>
  • <th>Quantitative Understanding</th>
  • <td><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>adjacent</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <th><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></th>
  • <th>adjacent</th>
  • <th>High </th>
  • <th></th>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- if nothing shows up in any of these fields, then evidence supporting this KER will not be displayed -->
  • <!--<!% unless aop_rel.relationship.relationship_taxons.blank? %>-->
  • <!--<!%= render 'snapshot_taxons', taxons: aop_rel.relationship.relationship_taxons %>-->
  • <!--<!% unless aop_rel.relationship.taxon_evidence.blank? %>-->
  • <!--<h3>Domain of Applicability</h3>-->
  • <!--<!%== aop_rel.relationship.taxon_evidence %>-->
  • <!--<!% end %>-->
  • <!--<!% end %>-->
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <br>
  • <h3>List of Non Adjacent Key Event Relationships</h3>
  • <div>
  • <h3>List of Non Adjacent Key Event Relationships</h3>
  • <div>
  • <h4><a href="/relationships/1071">Relationship: 1071: Activation of specific nuclear receptors, PPAR-gamma activation leads to Increased, adipogenesis</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP Name</th>
  • <th>Adjacency</th>
  • <th>Weight of Evidence</th>
  • <th>Quantitative Understanding</th>
  • <td><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>non-adjacent</td>
  • <td>High</td>
  • <td></td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <th><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></th>
  • <th>non-adjacent</th>
  • <th>High </th>
  • <th></th>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- if nothing shows up in any of these fields, then evidence supporting this KER will not be displayed -->
  • <!--<!% unless aop_rel.relationship.relationship_taxons.blank? %>-->
  • <!--<!%= render 'snapshot_taxons', taxons: aop_rel.relationship.relationship_taxons %>-->
  • <!--<!% unless aop_rel.relationship.taxon_evidence.blank? %>-->
  • <!--<h3>Domain of Applicability</h3>-->
  • <!--<!%== aop_rel.relationship.taxon_evidence %>-->
  • <!--<!% end %>-->
  • <!--<!% end %>-->
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <br>
  • <div>
  • <div>
  • <h4><a href="/relationships/1072">Relationship: 1072: Activation of specific nuclear receptors, PPAR-gamma activation leads to Increased, secretion of local growth factors</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP Name</th>
  • <th>Adjacency</th>
  • <th>Weight of Evidence</th>
  • <th>Quantitative Understanding</th>
  • <td><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></td>
  • <td>non-adjacent</td>
  • <td>Moderate</td>
  • <td></td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <th><a href="/aops/163">PPARgamma activation leading to sarcomas in rats, mice, and hamsters</a></th>
  • <th>non-adjacent</th>
  • <th>Moderate </th>
  • <th></th>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- if nothing shows up in any of these fields, then evidence supporting this KER will not be displayed -->
  • <!--<!% unless aop_rel.relationship.relationship_taxons.blank? %>-->
  • <!--<!%= render 'snapshot_taxons', taxons: aop_rel.relationship.relationship_taxons %>-->
  • <!--<!% unless aop_rel.relationship.taxon_evidence.blank? %>-->
  • <!--<h3>Domain of Applicability</h3>-->
  • <!--<!%== aop_rel.relationship.taxon_evidence %>-->
  • <!--<!% end %>-->
  • <!--<!% end %>-->
  • </div>
  • <br>
  • </tbody>
  • </table>
  • </div>
  • <!-- end relationship loop -->
  • </div>
  • </div>
  • </div>
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