AOP-Wiki

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~~<div class="pull-right">~~
~~<h1>SNAPSHOT</h1>~~
~~<h4>Created at: 2019-01-04 08:58</h4>~~
~~</div>~~
~~~~
<div id="title">
<h2>AOP ID and Title:</h2>
<hr>
~~<div class="title">~~
~~AOP 71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation~~
~~</div>~~
<div class="title">AOP 71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation</div>
<strong>Short Title: Decreased Adult Testosterone 2</strong>
~~<br>~~
</div>
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~~<hr>~~
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<div id="authors">
<h2>Authors</h2>
<hr>
~~<p>Gary Klinefelter~~
~~and~~
~~Susan Laws~~
~~</p>~~
<p>Gary Klinefelter and Susan Laws</p>
~~<br>~~
</div>
~~~~
<div id="status">
<h2>Status</h2>
~~<div class="panel panel-default">~~
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
~~<th>Author status</th>~~
<th>OECD status</th>
<th>OECD project</th>
<th>SAAOP status</th>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
<th scope="col">Author status</th>
<th scope="col">OECD status</th>
<th scope="col">OECD project</th>
<th scope="col">SAAOP status</th>
</tr>
</thead>
<tbody class="tbody-striped">
<tr>
~~<td>Under development: Not open for comment. Do not cite</td>~~
<td>Under Development: Contributions and Comments Welcome</td>
<td></td>
<td></td>
~~<td>1.29</td>~~
<td>Under Development</td>
</tr>
</tbody>
</table>
</div>
</div>
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<div id="abstract">
~~<br>~~
</div>
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~~<div id="background">~~
~~<br>~~
~~</div>~~
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<div id="aop_summary">
<h2>Summary of the AOP</h2>
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<h3>Events</h3>
~~<h3>Molecular Initiating Events (MIE), Key Events (KE), Adverse Outcomes (AO)</h3>~~
~~<div class="panel panel-default">~~
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
~~<tr>~~
<th>Sequence</th>
<th>Type</th>
<th>Event ID</th>
<th>Title</th>
<th>Short name</th>
~~</tr>~~
~~</thead>~~
~~<tbody>~~
~~<tr>~~
~~<td>1</td>~~
~~<td>MIE</td>~~
~~<td>650</td>~~
~~<td><a href="/events/650">Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid</a></td>~~
~~<td>Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid</td>~~
~~</tr>~~
~~<tr><td></td><td></td><td></td><td></td><td></td></tr>~~
~~<tr>~~
~~<td>2</td>~~
~~<td>KE</td>~~
~~<td>525</td>~~
~~<td><a href="/events/525">Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells</a></td>~~
~~<td>Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells</td>~~
~~</tr>~~
~~<tr>~~
~~<td>3</td>~~
~~<td>KE</td>~~
~~<td>651</td>~~
~~<td><a href="/events/651">Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells</a></td>~~
~~<td>Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testostero</td>~~
~~</tr>~~
~~<tr>~~
~~<td>4</td>~~
~~<td>KE</td>~~
~~<td>652</td>~~
~~<td><a href="/events/652">Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells</a></td>~~
~~<td>Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig</td>~~
~~</tr>~~
~~<tr><td></td><td></td><td></td><td></td><td></td></tr>~~
~~<tr>~~
~~<td>5</td>~~
~~<td>AO</td>~~
~~<td>520</td>~~
~~<td><a href="/events/520">Decreased sperm quantity or quality in the adult, Decreased fertility </a></td>~~
~~<td>Decreased sperm quantity or quality in the adult, Decreased fertility </td>~~
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
<h3>Molecular Initiating Events (MIE), Key Events (KE), Adverse Outcomes (AO)</h3>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
<th scope="col">Sequence</th>
<th scope="col">Type</th>
<th scope="col">Event ID</th>
<th scope="col">Title</th>
<th scope="col">Short name</th>
</tr>
</thead>
<tbody>
<tr>
<td>1</td>
<td>MIE</td>
<td>650</td>
<td><a href="/events/650">Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid</a></td>
<td>Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid</td>
</tr>
<tr><td></td><td></td><td></td><td></td><td></td></tr>
<tr>
<td>2</td>
<td>KE</td>
<td>525</td>
<td><a href="/events/525">Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells</a></td>
<td>Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells</td>
</tr>
<tr>
<td>3</td>
<td>KE</td>
<td>651</td>
<td><a href="/events/651">Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells</a></td>
<td>Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testostero</td>
</tr>
<tr>
<td>4</td>
<td>KE</td>
<td>652</td>
<td><a href="/events/652">Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells</a></td>
<td>Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig</td>
</tr>
<tr><td></td><td></td><td></td><td></td><td></td></tr>
<tr>
<td>5</td>
<td>AO</td>
<td>520</td>
<td><a href="/events/520">Decreased sperm quantity or quality in the adult, Decreased fertility </a></td>
<td>Decreased sperm quantity or quality in the adult, Decreased fertility </td>
</tr>
</tbody>
</table>
</div>
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<h3>Key Event Relationships</h3>
~~There are no Relationships associated with this AOP~~
There are no Relationships associated with this AOP
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</div>
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<div id="overall_assessment">
<h2>Overall Assessment of the AOP</h2>
~~<hr>~~
~~<h3>Domain of Applicability</h3>~~
~~<strong>Life Stage Applicability</strong>~~
~~<div class="panel panel-default">~~
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
<h3>Domain of Applicability</h3>
<strong>Life Stage Applicability</strong>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
~~<th>Life Stage</th>~~
~~<th>Evidence</th>~~
<th scope="col">Life Stage</th>
<th scope="col">Evidence</th>
</tr>
</thead>
~~<tbody>~~
~~<tr>~~
~~<td>Adult, reproductively mature</td>~~
~~<td>High</td>~~
~~</tr>~~
<tbody class="tbody-striped">
<tr>
<td>Adult, reproductively mature</td>
<td>High</td>
</tr>
</tbody>
</table>
</div>
~~<strong>Taxonomic Applicability</strong>~~
~~<div class="panel panel-default">~~
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<strong>Taxonomic Applicability</strong>
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<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
~~<th>Term</th>~~
~~<th>Scientific Term</th>~~
~~<th>Evidence</th>~~
~~<th>Links</th>~~
<th scope="col">Term</th>
<th scope="col">Scientific Term</th>
<th scope="col">Evidence</th>
<th scope="col">Links</th>
</tr>
</thead>
~~<tbody>~~
~~<tr>~~
~~<td>Rattus norvegicus</td>~~
~~<td>Rattus norvegicus</td>~~
~~<td>High</td>~~
~~<td>~~
~~<a href="http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=10116" , target="_blank">NCBI</a>~~
~~</td>~~
~~</tr>~~
~~<tr>~~
~~<td>Homo sapiens</td>~~
~~<td>Homo sapiens</td>~~
~~<td>High</td>~~
~~<td>~~
~~<a href="http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606" , target="_blank">NCBI</a>~~
~~</td>~~
~~</tr>~~
<tbody class="tbody-striped">
<tr>
<td>Rattus norvegicus</td>
<td>Rattus norvegicus</td>
<td>High</td>
<td><a href="http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=10116" target="_blank">NCBI</a></td>
</tr>
<tr>
<td>Homo sapiens</td>
<td>Homo sapiens</td>
<td>High</td>
<td><a href="http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606" target="_blank">NCBI</a></td>
</tr>
</tbody>
</table>
</div>
~~<strong>Sex Applicability</strong>~~
~~<div class="panel panel-default">~~
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
<strong>Sex Applicability</strong>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
~~<th>Sex</th>~~
~~<th>Evidence</th>~~
<th scope="col">Sex</th>
<th scope="col">Evidence</th>
</tr>
</thead>
~~<tbody>~~
~~<tr>~~
~~<td>Male</td>~~
~~<td>High</td>~~
~~</tr>~~
<tbody class="tbody-striped">
<tr>
<td>Male</td>
<td>High</td>
</tr>
</tbody>
</table>
</div>
</div>
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<div id="considerations_for_potential_applicaitons">
</div>
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<div id="references">
<h2>References</h2>
~~<hr>~~
~~<br>~~
</div>
<div id="appendicies">
<h2>Appendix 1</h2>
<h3>List of MIEs in this AOP</h3>
<div>
~~<div>~~
~~<h4><a href="/events/650">Event: 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid</a><br></h4>~~
~~<h5>Short Name: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid</h5>~~
</div>
<h4>Key Event Component</h4>
~~<div class="panel panel-default">~~
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
~~<tr>~~
~~<th>Process</th>~~
~~<th>Object</th>~~
<th>Action</th>
~~</tr>~~
~~</thead>~~
~~<tbody>~~
~~<tr>~~
<td>glucocorticoid biosynthetic process</td>
~~<td>glucocorticoid</td>~~
~~<td>increased</td>~~
</tr>
~~<tr>~~
~~<td>cell activation</td>~~
~~<td></td>~~
<td>increased</td>
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
~~<div>~~
~~~~
~~<h4>AOPs Including This Key Event</h4>~~
<div class="panel panel-default">
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
<h4><a href="/events/650">Event: 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid</a></h4>
<h5>Short Name: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid</h5>
<h4>Event Component</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
<th scope="col">Process</th>
<th scope="col">Object</th>
<th scope="col">Action</th>
</tr>
</thead>
<tbody class="tbody-striped">
<tr>
~~<th>AOP ID and Name</th>~~
~~<th>Event Type</th>~~
<td>glucocorticoid biosynthetic process</td>
<td>glucocorticoid</td>
<td>increased</td>
</tr>
</thead>
~~<tbody>~~
~~<tr>~~
~~<td><a href="/aops/71">Aop:71 - Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation</a></td>~~
~~<td>MolecularInitiatingEvent</td>~~
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
~~</div>~~
~~~~
~~<div>~~
~~</div>~~
~~<br>~~
~~~~
~~<div>~~
~~<h4>Biological Context</h4>~~
~~<div class="panel panel-default">~~
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
~~<tr>~~
~~<th>Level of Biological Organization</th>~~
~~</tr>~~
</thead>
~~<tbody>~~
~~<tr>~~
~~<td>Molecular</td>~~
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
~~</div>~~
~~~~
~~~~
~~<div>~~
~~</div>~~
~~~~
~~~~
~~<div>~~
<tr>
<td>cell activation</td>
<td></td>
<td>increased</td>
</tr>
</tbody>
</table>
</div>
~~~~
~~~~
~~~~

<!-- end event text -->
<h4>AOPs Including This Key Event</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
<th scope="col">AOP ID and Name</th>
<th scope="col">Event Type</th>
</tr>
</thead>
<tbody class="tbody-striped">
<tr>
<td><a href="/aops/71">Aop:71 - Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation</a></td>
<td>MolecularInitiatingEvent</td>
</tr>
</tbody>
</table>
</div>
<h3>List of Key Events in the AOP</h3>
~~<div>~~
<div>
~~<h4><a href="/events/525">Event: 525: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells</a><br></h4>~~
<h5>Short Name: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells</h5>
<h4>Biological Context</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr><th scope="col">Level of Biological Organization</th></tr>
</thead>
<tbody class="tbody-striped">
<tr><td>Molecular</td></tr>
</tbody>
</table>
</div>
~~<h4>Key Event Component</h4>~~
~~<div class="panel panel-default">~~
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
~~<tr>~~
~~<th>Process</th>~~
~~<th>Object</th>~~
~~<th>Action</th>~~
~~</tr>~~
~~</thead>~~
~~<tbody>~~
~~<tr>~~
~~<td></td>~~
~~<td>testosterone</td>~~
~~<td>decreased</td>~~
~~</tr>~~
~~<tr>~~
~~<td>apoptotic process</td>~~
~~<td></td>~~
~~<td>increased</td>~~
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
<div>
<!-- loop to find all aops that use this event -->
<h4>AOPs Including This Key Event</h4>
~~<div class="panel panel-default">~~
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
<h3>List of Key Events in the AOP</h3>
<h4><a href="/events/525">Event: 525: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells</a></h4>
<h5>Short Name: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells</h5>
<h4>Event Component</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
<th scope="col">Process</th>
<th scope="col">Object</th>
<th scope="col">Action</th>
</tr>
</thead>
<tbody class="tbody-striped">
<tr>
~~<th>AOP ID and Name</th>~~
~~<th>Event Type</th>~~
<td></td>
<td>testosterone</td>
<td>decreased</td>
</tr>
</thead>
~~<tbody>~~
~~<tr>~~
~~<td><a href="/aops/71">Aop:71 - Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation</a></td>~~
~~<td>KeyEvent</td>~~
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
~~</div>~~
~~~~
~~<div>~~
<tr>
<td>apoptotic process</td>
<td></td>
<td>increased</td>
</tr>
</tbody>
</table>
</div>
~~<br>~~
<!-- biological organization -->
~~<div>~~
<h4>Biological Context</h4>
~~<div class="panel panel-default">~~
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
~~<tr>~~
<th>Level of Biological Organization</th>
~~</tr>~~
~~</thead>~~
~~<tbody>~~
~~<tr>~~
~~<td>Cellular</td>~~
~~</tr>~~
<h4>AOPs Including This Key Event</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
<th scope="col">AOP ID and Name</th>
<th scope="col">Event Type</th>
</tr>
</thead>
<tbody class="tbody-striped">
<tr>
<td><a href="/aops/71">Aop:71 - Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation</a></td>
<td>KeyEvent</td>
</tr>
</tbody>
</table>
</div>
</tbody>
~~</table>~~
~~</div>~~
<h4>Biological Context</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr><th scope="col">Level of Biological Organization</th></tr>
</thead>
<tbody class="tbody-striped">
<tr><td>Cellular</td></tr>
</tbody>
</table>
</div>
<!-- end of bio org -->
~~~~
~~<div>~~
~~<h4>Cell term</h4>~~
~~<div class="panel panel-default">~~
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
~~<tr>~~
<th>Cell term</th>
~~</tr>~~
~~</thead>~~
~~<tbody>~~
~~<tr>~~
~~<td>Leydig cell</td>~~
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
<h4>Cell term</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr><th scope="col">Cell term</th></tr>
</thead>
<tbody class="tbody-striped">
<tr><td>Leydig cell</td></tr>
</tbody>
</table>
</div>
~~~~
<!-- organ term -->
<div>
<h4><a href="/events/651">Event: 651: Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells</a></h4>
<h5>Short Name: Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testostero</h5>
<h4>Event Component</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
<th scope="col">Process</th>
<th scope="col">Object</th>
<th scope="col">Action</th>
</tr>
</thead>
<tbody class="tbody-striped">
<tr>
<td>glucocorticoid receptor activity</td>
<td>glucocorticoid receptor</td>
<td>abnormal</td>
</tr>
</tbody>
</table>
</div>
~~~~
~~~~
~~~~
<!-- event text -->

<h4>AOPs Including This Key Event</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
<th scope="col">AOP ID and Name</th>
<th scope="col">Event Type</th>
</tr>
</thead>
<tbody class="tbody-striped">
<tr>
<td><a href="/aops/71">Aop:71 - Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation</a></td>
<td>KeyEvent</td>
</tr>
</tbody>
</table>
</div>
<div>
~~<div>~~
<h4><a href="/events/651">Event: 651: Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells</a><br></h4>
<h5>Short Name: Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testostero</h5>
<h4>Biological Context</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr><th scope="col">Level of Biological Organization</th></tr>
</thead>
<tbody class="tbody-striped">
<tr><td>Cellular</td></tr>
</tbody>
</table>
</div>
<h4>Key Event Component</h4>
~~<div class="panel panel-default">~~
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
~~<tr>~~
<th>Process</th>
<th>Object</th>
~~<th>Action</th>~~
~~</tr>~~
~~</thead>~~
~~<tbody>~~
~~<tr>~~
~~<td>glucocorticoid receptor activity</td>~~
~~<td>glucocorticoid receptor</td>~~
<td>abnormal</td>
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
~~<div>~~
~~~~
~~<h4>AOPs Including This Key Event</h4>~~
<div class="panel panel-default">
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
<h4><a href="/events/652">Event: 652: Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells</a></h4>
<h5>Short Name: Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig</h5>
<h4>Event Component</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
<th scope="col">Process</th>
<th scope="col">Object</th>
<th scope="col">Action</th>
</tr>
</thead>
<tbody class="tbody-striped">
<tr>
~~<th>AOP ID and Name</th>~~
~~<th>Event Type</th>~~
<td>regulation of steroid biosynthetic process</td>
<td></td>
<td>abnormal</td>
</tr>
~~</thead>~~
~~<tbody>~~
~~<tr>~~
~~<td><a href="/aops/71">Aop:71 - Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation</a></td>~~
~~<td>KeyEvent</td>~~
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
~~</div>~~
~~~~
~~<div>~~
~~</div>~~
~~<br>~~
~~~~
~~<div>~~
~~<h4>Biological Context</h4>~~
~~<div class="panel panel-default">~~
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
~~<tr>~~
~~<th>Level of Biological Organization</th>~~
~~</tr>~~
~~</thead>~~
~~<tbody>~~
~~<tr>~~
~~<td>Cellular</td>~~
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
~~</div>~~
~~~~
~~~~
~~<div>~~
~~</div>~~
~~~~
~~~~
<div>
</tbody>
</table>
</div>
~~~~
~~~~
~~~~
~~~~
~~<!-- end event text -->~~
<h4>AOPs Including This Key Event</h4>
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<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
<th scope="col">AOP ID and Name</th>
<th scope="col">Event Type</th>
</tr>
</thead>
<tbody class="tbody-striped">
<tr>
<td><a href="/aops/71">Aop:71 - Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation</a></td>
<td>KeyEvent</td>
</tr>
</tbody>
</table>
</div>
~~<div>~~
~~<div>~~
~~<h4><a href="/events/652">Event: 652: Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells</a><br></h4>~~
<h5>Short Name: Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig</h5>
<h4>Biological Context</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr><th scope="col">Level of Biological Organization</th></tr>
</thead>
<tbody class="tbody-striped">
<tr><td>Cellular</td></tr>
</tbody>
</table>
</div>
~~<h4>Key Event Component</h4>~~
~~<div class="panel panel-default">~~
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
~~<tr>~~
~~<th>Process</th>~~
~~<th>Object</th>~~
~~<th>Action</th>~~
~~</tr>~~
~~</thead>~~
~~<tbody>~~
~~<tr>~~
~~<td>regulation of steroid biosynthetic process</td>~~
~~<td></td>~~
~~<td>abnormal</td>~~
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
~~<div>~~
~~~~
~~<h4>AOPs Including This Key Event</h4>~~
~~<div class="panel panel-default">~~
<table class="table table-bordered table-striped">
~~<thead>~~
<h3>List of Adverse Outcomes in this AOP</h3>
<h4><a href="/events/520">Event: 520: Decreased sperm quantity or quality in the adult, Decreased fertility </a></h4>
<h5>Short Name: Decreased sperm quantity or quality in the adult, Decreased fertility </h5>
<h4>Event Component</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
<th scope="col">Process</th>
<th scope="col">Object</th>
<th scope="col">Action</th>
</tr>
</thead>
<tbody class="tbody-striped">
<tr>
~~<th>AOP ID and Name</th>~~
~~<th>Event Type</th>~~
<td>sperm quantity</td>
<td></td>
<td>decreased</td>
</tr>
~~</thead>~~
~~<tbody>~~
<tr>
~~<td><a href="/aops/71">Aop:71 - Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation</a></td>~~
~~<td>KeyEvent</td>~~
~~</tr>~~
~~</tbody>~~
~~</table>~~
</div>
~~</div>~~
~~~~
~~<div>~~
~~</div>~~
~~<br>~~
~~~~
~~<div>~~
~~<h4>Biological Context</h4>~~
<div class="panel panel-default">
~~<table class="table table-bordered table-striped">~~
<thead>
~~<tr>~~
<th>Level of Biological Organization</th>
~~</tr>~~
</thead>
~~<tbody>~~
<tr>
~~<td>Cellular</td>~~
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
~~</div>~~
~~~~
~~~~
~~<div>~~
~~</div>~~
~~~~
~~~~
~~<div>~~
<tr>
<td></td>
<td>sperm</td>
<td>morphological change</td>
</tr>
<tr>
<td></td>
<td>fertility</td>
<td>decreased</td>
</tr>
<tr>
<td></td>
<td>sperm</td>
<td>decreased</td>
</tr>
</tbody>
</table>
</div>
~~~~
~~~~
~~~~
~~~~
~~<!-- end event text -->~~
<h4>AOPs Including This Key Event</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr>
<th scope="col">AOP ID and Name</th>
<th scope="col">Event Type</th>
</tr>
</thead>
<tbody class="tbody-striped">
<tr>
<td><a href="/aops/70">Aop:70 - Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell</a></td>
<td>AdverseOutcome</td>
</tr>
<tr>
<td><a href="/aops/71">Aop:71 - Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation</a></td>
<td>AdverseOutcome</td>
</tr>
<tr>
<td><a href="/aops/64">Aop:64 - Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility</a></td>
<td>KeyEvent</td>
</tr>
<tr>
<td><a href="/aops/476">Aop:476 - Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity</a></td>
<td>AdverseOutcome</td>
</tr>
<tr>
<td><a href="/aops/595">Aop:595 - Nanoplastic effect</a></td>
<td>AdverseOutcome</td>
</tr>
</tbody>
</table>
</div>
~~<h3>List of Adverse Outcomes in this AOP</h3>~~
~~<div>~~
~~<div>~~
<h4><a href="/events/520">Event: 520: Decreased sperm quantity or quality in the adult, Decreased fertility </a><br></h4>
~~<h5>Short Name: Decreased sperm quantity or quality in the adult, Decreased fertility </h5>~~
~~</div>~~
<h4>Key Event Component</h4>
<div class="panel panel-default">
~~<table class="table table-bordered table-striped">~~
~~<thead>~~
~~<tr>~~
~~<th>Process</th>~~
~~<th>Object</th>~~
~~<th>Action</th>~~
~~</tr>~~
~~</thead>~~
~~<tbody>~~
~~<tr>~~
~~<td>sperm quantity</td>~~
~~<td></td>~~
~~<td>decreased</td>~~
~~</tr>~~
~~<tr>~~
~~<td></td>~~
~~<td>sperm</td>~~
~~<td>morphological change</td>~~
~~</tr>~~
~~<tr>~~
~~<td></td>~~
~~<td>fertility</td>~~
~~<td>decreased</td>~~
~~</tr>~~
~~<tr>~~
~~<td></td>~~
~~<td>sperm</td>~~
~~<td>decreased</td>~~
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
~~<div>~~
~~~~
~~<h4>AOPs Including This Key Event</h4>~~
<div class="panel panel-default">
<table class="table table-bordered table-striped">
~~<thead>~~
~~<tr>~~
~~<th>AOP ID and Name</th>~~
~~<th>Event Type</th>~~
~~</tr>~~
~~</thead>~~
~~<tbody>~~
<tr>
~~<td><a href="/aops/70">Aop:70 - Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell</a></td>~~
~~<td>AdverseOutcome</td>~~
~~</tr>~~
~~<tr>~~
~~<td><a href="/aops/71">Aop:71 - Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation</a></td>~~
~~<td>AdverseOutcome</td>~~
</tr>
~~<tr>~~
~~<td><a href="/aops/64">Aop:64 - Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility</a></td>~~
~~<td>KeyEvent</td>~~
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
~~</div>~~
~~~~
~~<div>~~
~~</div>~~
~~<br>~~

~~<div>~~
~~<h4>Biological Context</h4>~~
~~<div class="panel panel-default">~~
<table class="table table-bordered table-striped">
~~<thead>~~
~~<tr>~~
~~<th>Level of Biological Organization</th>~~
~~</tr>~~
~~</thead>~~
~~<tbody>~~
~~<tr>~~
~~<td>Individual</td>~~
~~</tr>~~
~~</tbody>~~
~~</table>~~
~~</div>~~
~~</div>~~
~~~~
~~~~
~~<div>~~
~~</div>~~
~~~~
~~~~
~~<div>~~
~~</div>~~
~~~~
~~~~
~~~~
~~~~
~~~~
~~</div>~~
<h4>Biological Context</h4>
<div class="table-responsive">
<table class="table table-bordered table-fullwidth">
<thead class="thead-light">
<tr><th scope="col">Level of Biological Organization</th></tr>
</thead>
<tbody class="tbody-striped">
<tr><td>Individual</td></tr>
</tbody>
</table>
</div>
<h2>Appendix 2</h2>
<h2>List of Key Event Relationships in the AOP</h2>
~~There are no Relationships associated with this AOP~~
There are no Relationships associated with this AOP
</div>
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