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Showing 351 to 375 of 548 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
412 Endothelial cell dysfunction leading to thromboinflammation Arthur Author All rights reserved None 1916: Thromboinflammation, Increased Under Development 1.96
413 Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Agnes Aggy BY-SA 926: Oxidation, Glutathione (To be considered with MIE) 351: Increased Mortality
414 Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway Allie Always All rights reserved 18: Activation, AhR None
415 Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway Evgeniia Kazymova All rights reserved 18: Activation, AhR 1276: Lung fibrosis
416 Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway Cataia Ives All rights reserved 18: Activation, AhR 1670: Lung cancer
417 Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway Brendan Ferreri-Hanberry All rights reserved 18: Activation, AhR 1670: Lung cancer
418 Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway Arthur Author All rights reserved None None
419 Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Agnes Aggy All rights reserved None 1250: Decrease, Lung function
420 Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Allie Always All rights reserved 18: Activation, AhR None
421 PPARG activation leading to intrahepatic cholestasis Evgeniia Kazymova All rights reserved None None
422 Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption Cataia Ives BY-SA 1739: Binding to ACE2 None Under Development 1.96
423 Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Brendan Ferreri-Hanberry BY-SA 1817: Apoptotic cell death
424 Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Arthur Author BY-SA 1392: Oxidative Stress 1250: Decrease, Lung function
425 Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Agnes Aggy BY-SA 1392: Oxidative Stress 1250: Decrease, Lung function
426 SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. Allie Always BY-SA 1739: Binding to ACE2 1934: Myocardial Infarction
427 ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. Evgeniia Kazymova BY-SA 1739: Binding to ACE2 1535: Heart failure
428 Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis Cataia Ives BY-SA 1739: Binding to ACE2 None Under Development 1.96
429 A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants Brendan Ferreri-Hanberry BY-SA None 1941: Memory Loss
430 Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation Arthur Author All rights reserved 1739: Binding to ACE2 1939: Viral infection and host-to-host transmission, proliferated Under Development 1.96
431 Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) Agnes Aggy BY-SA 1950: Increase, TNF 1953: Gestational diabetes mellitus
432 Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Allie Always All rights reserved 1686: Deposition of Energy 1955: Acute Myeloid Leukemia
433 hERG channel blockade leading to sudden cardiac death Evgeniia Kazymova BY-SA 2099: hERG channel blockade 1964: Sudden cardiac death
434 CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects Cataia Ives All rights reserved None None
435 Deposition of ionising energy leads to population decline via pollen abnormal Brendan Ferreri-Hanberry BY-SA 1686: Deposition of Energy
436 Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries Arthur Author BY-SA 1880: Decreased, ALDH1A (RALDH) enzyme activity 1970: transposition of the great arteries