AOPs

OECD View API
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Showing 551 to 575 of 582 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
612 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate Agnes Aggy BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
613 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production Allie Always BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
614 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor Evgeniia Kazymova BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
615 Suppression of Keap1 cysteine oxidation leading to liver inflammation Cataia Ives All rights reserved 2385: Suppression of Keap1 cysteine oxidation 902: Inflammation, Liver
616 organic UV filter and its Photoproducts reproductive toxicity pathways Brendan Ferreri-Hanberry All rights reserved 2391: Reduced fertility / fecundity
617 The adverse outcome pathway of vascular calcification Arthur Author All rights reserved None None
618 PPARgamma activation leads to a diminished vaccine response Agnes Aggy BY-SA 1028: Activation of specific nuclear receptors, PPAR-gamma activation 2397: Diminished vaccine response
619 Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues Allie Always BY-SA 26: Antagonism, Androgen receptor 2401: Male preputial separation, failed/delayed
620 The Adverse Outcome Pathway to Deposition of Energy Leading to Female Decreased Fertility Evgeniia Kazymova All rights reserved None None
621 NOX2 Driven Oxidative Stress-Induced α-Synuclein Radical Formation and Tau Nitration Leading to Neurodegeneration Cataia Ives Open for adoption None None
622 Calcineurin inhibitor induced nephrotoxicity leading to kidney failure Brendan Ferreri-Hanberry BY-SA None 759: Increased, Kidney Failure
623 Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release Arthur Author BY-SA 1065: Activation, estrogen receptor alpha 2306: Persistent vaginal cornification
624 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction Agnes Aggy BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
625 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress Allie Always BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
626 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress Evgeniia Kazymova BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
627 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction Cataia Ives BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
628 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress Brendan Ferreri-Hanberry BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
629 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress Arthur Author BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
630 Decreased 11β-Hydroxysteroid dehydrogenase type 2 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction Agnes Aggy BY-SA 2409: Decrease, 11β-Hydroxysteroid dehydrogenase type 2 activity None Under Development
631 Decreased thyroid hormone receptor beta transcriptional activity leading to MASLD progression via endoplasmic reticulum stress Allie Always BY-SA None None
632 Increased adrenal glucocorticoid production leading to MASLD progression (3) Evgeniia Kazymova BY-SA None None
633 Increased adrenal glucocorticoid production leading to MASLD progression (4) Cataia Ives BY-SA None None
634 Increased adrenal glucocorticoid production leading to MASLD progression (5) Brendan Ferreri-Hanberry BY-SA None None
635 Increased adrenal glucocorticoid production leading to MASLD progression (6) Arthur Author BY-SA None None
636 Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS) Agnes Aggy All rights reserved 1115: Increase, Reactive oxygen species 2416: human amyotrophic lateral sclerosis (ALS)