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Showing 201 to 225 of 548 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
237 Substance interaction with lung resident cell membrane components leading to atherosclerosis Arthur Author BY-SA 1495: Substance interaction with the lung resident cell membrane components 1443: Atherosclerosis Under Development 1.55
238 Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis Agnes Aggy BY-SA 1686: Deposition of Energy
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Allie Always BY-SA None None
240 DNA Adducts Leading to Liver Hemangiosarcoma Evgeniia Kazymova BY-SA None None
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Cataia Ives BY-SA 1468: Activation, Latent Transforming Growth Factor Beta 1 1458: Pulmonary fibrosis
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Brendan Ferreri-Hanberry Open for adoption 1462: Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
245 Reduction in photophosphorylation leading to growth inhibition in aquatic plants Arthur Author BY-SA 1471: Increase, Uncoupling of photophosphorylation 1521: Decrease, Growth
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Agnes Aggy BY-SA 1481: Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) 814: Occurrence, Kidney toxicity Under Development 1.43
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Allie Always BY-SA 1486: Binding of substrate, endocytic receptor 814: Occurrence, Kidney toxicity Under Development 1.43
258 Renal protein alkylation leading to kidney toxicity Evgeniia Kazymova BY-SA 244: Alkylation, Protein 814: Occurrence, Kidney toxicity Under Development 1.43
259 Sensitization induction of the intestinal tract by food proteins Cataia Ives BY-SA None None
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Brendan Ferreri-Hanberry BY-SA 1514: Neurodegeneration
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Arthur Author All rights reserved 1529: Blockade, L-Type Calcium Channels 1535: Heart failure Under Development 1.45
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Agnes Aggy All rights reserved None None Under Development 1.45
263 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation Allie Always BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth WPHA/WNT Endorsed 1.92
264 Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death Evgeniia Kazymova BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium Cataia Ives BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity Brendan Ferreri-Hanberry BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion Arthur Author BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
268 Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling Agnes Aggy BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
269 Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Allie Always BY-SA None None
270 Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Evgeniia Kazymova All rights reserved None None
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish Cataia Ives BY-SA 279: Thyroperoxidase, Inhibition 78: Reduction, Cumulative fecundity and spawning Under Development 1.59
272 Deposition of energy leading to lung cancer Brendan Ferreri-Hanberry BY-SA 1686: Deposition of Energy 1556: Increase, lung cancer WPHA/WNT Endorsed 1.56
273 Mitochondrial complex inhibition leading to liver injury Arthur Author BY-SA