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Showing 226 to 250 of 548 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
274 Histone deacetylase inhibition leads to impeded craniofacial development Agnes Aggy BY-SA 1502: Histone deacetylase inhibition 1559: Facial cartilage structures are reduced in size and morphologically distorted
275 Histone deacetylase inhibition leads to neural tube defects Allie Always BY-SA 1502: Histone deacetylase inhibition 1561: Neural tube defects
276 Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Evgeniia Kazymova BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 1564: Chemical induced Fanconi syndrome
277 Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response Cataia Ives BY-SA 1700: Impaired IL-1R1 signaling in T cell 984: Impairment, T-cell dependent antibody response WPHA/WNT Endorsed 1.48
278 IKK complex inhibition leading to liver injury Brendan Ferreri-Hanberry BY-SA 1574: Inhibition, IKK complex
279 Microtubule interacting drugs lead to peripheral neuropathy Arthur Author BY-SA 1580: Binding of microtubule stabilizing agents (MSA) to microtubules 1583: Sensory axonal peripheral neuropathy
280 α-diketone-induced bronchiolitis obliterans Agnes Aggy BY-SA 1584: Interaction of α-diketones with arginine residues 1588: Bronchiolitis obliterans
281 Acetylcholinesterase Inhibition Leading to Neurodegeneration Allie Always BY-SA 12: Acetylcholinesterase (AchE) Inhibition 352: N/A, Neurodegeneration
282 Adverse outcome pathway on photochemical toxicity initiated by light exposure Evgeniia Kazymova BY-SA 1115: Increase, Reactive oxygen species 1599: Inflamatory events in light-exposed tissues Under Review 1.49
283 L-type calcium channel blockade leading to hypotension Cataia Ives All rights reserved None None Under Development 1.45
284 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Brendan Ferreri-Hanberry BY-SA 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 1603: Chronic kidney disease
285 Inhibition of N-linked glycosylation leads to liver injury Arthur Author BY-SA 1604: Inhibition of N-linked glycosylation 1549: Liver Injury
286 Mitochondrial complex III antagonism leading to growth inhibition (1) Agnes Aggy BY-SA 1542: Inhibition, Mitochondrial complex III 1521: Decrease, Growth
287 Mitochondrial complex III antagonism leading to growth inhibition (2) Allie Always BY-SA 1542: Inhibition, Mitochondrial complex III 1521: Decrease, Growth
288 Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Evgeniia Kazymova BY-SA 1609: Inhibition, Cytochrome P450 enzyme (CYP17A1) activity 1616: Malformation, cryptorchidism - maldescended testis
289 Inhibition of 5α-reductase leading to impaired fecundity in female fish Cataia Ives BY-SA 1617: Inhibition, 5α-reductase 360: Decrease, Population growth rate Under Development 1.81
290 Mitochondrial ATP synthase antagonism leading to growth inhibition (1) Brendan Ferreri-Hanberry BY-SA 1785: Increase, Mitochondrial ATP synthase antagonism 1521: Decrease, Growth
291 Mitochondrial ATP synthase antagonism leading to growth inhibition (2) Arthur Author BY-SA 1785: Increase, Mitochondrial ATP synthase antagonism 1521: Decrease, Growth
292 Inhibition of tyrosinase leads to decreased population in fish Agnes Aggy BY-SA 1627: Inhibition of tyrosinase 360: Decrease, Population growth rate Under Development 1.78
293 Increased DNA damage leading to increased risk of breast cancer Allie Always BY-SA 1194: Increase, DNA damage Under Development 1.80
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Evgeniia Kazymova BY-SA 1632: Increase in reactive oxygen and nitrogen species (RONS) Under Development 1.80
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Cataia Ives BY-SA None None Under Development 1.79
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Brendan Ferreri-Hanberry BY-SA 1634: Increase, Oxidative DNA damage WPHA/WNT Endorsed 1.76
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Arthur Author BY-SA 1637: Retinaldehyde dehydrogenase inhibition 360: Decrease, Population growth rate Under Development 1.77
298 Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer Agnes Aggy BY-SA 1115: Increase, Reactive oxygen species 1651: Treatment-resistant gastric cancer Under Review 1.58