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Showing 76 to 100 of 548 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
96 Axonal sodium channel modulation leading to acute mortality Arthur Author BY-SA 598: modulation, sodium channel 351: Increased Mortality
97 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Agnes Aggy BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
98 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Allie Always BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 588: Increased, predation
99 Histamine (H2) receptor antagonism leading to reduced survival Evgeniia Kazymova BY-SA 638: Antagonism, Histamine Receptor (H2)
100 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Cataia Ives BY-SA 79: Inhibition, Cyclooxygenase activity
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Brendan Ferreri-Hanberry BY-SA 79: Inhibition, Cyclooxygenase activity
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Arthur Author BY-SA 79: Inhibition, Cyclooxygenase activity
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Agnes Aggy BY-SA 79: Inhibition, Cyclooxygenase activity
104 Altered ion channel activity leading impaired heart function Allie Always BY-SA 697: impaired, ion channels 351: Increased Mortality
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Evgeniia Kazymova BY-SA 714: Increased, Binding of chemicals to 2u (serum) 713: Increase, Adenomas/carcinomas (renal tubular)
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Cataia Ives BY-SA 718: Binding, Tubulin 728: Increase, Aneuploid offspring Under Review 1.11
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Brendan Ferreri-Hanberry BY-SA 715: Activation, Constitutive androstane receptor 719: Increase, hepatocellular adenomas and carcinomas Under Review 1.17
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Arthur Author BY-SA 724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme 719: Increase, hepatocellular adenomas and carcinomas
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Agnes Aggy BY-SA 770: Increase, Cytotoxicity (club cells) 736: Increase, Adenomas/carcinomas (bronchioloalveolar)
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Allie Always BY-SA 424: Inhibition, Na+/I- symporter (NIS) 741: Increase, Adenomas/carcinomas (follicular cell)
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Evgeniia Kazymova BY-SA 1614: Decrease, androgen receptor activation 745: Increase, Leydig cell tumors
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Cataia Ives BY-SA 746: Increase, Dopaminergic activity 773: Increase, Endometrial adenocarcinomas
113 Glutamate-gated chloride channel activation leading to acute mortality Brendan Ferreri-Hanberry BY-SA 760: Activation, Glutamate-gated chloride channel
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Arthur Author BY-SA 766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme 779: Increase, Papillomas/carcinomas (squamous cells)
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Agnes Aggy BY-SA 780: Increase, Cytotoxicity (epithelial cells) 779: Increase, Papillomas/carcinomas (squamous cells)
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Allie Always BY-SA 783: Increase, Cytotoxicity (tubular epithelial cells) 713: Increase, Adenomas/carcinomas (renal tubular)
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Evgeniia Kazymova Open for adoption 25: Agonism, Androgen receptor 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.26
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Cataia Ives BY-SA 786: Increase, Cytotoxicity (hepatocytes) 719: Increase, hepatocellular adenomas and carcinomas
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Brendan Ferreri-Hanberry BY-SA 279: Thyroperoxidase, Inhibition 741: Increase, Adenomas/carcinomas (follicular cell)
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Arthur Author BY-SA 1617: Inhibition, 5α-reductase 745: Increase, Leydig cell tumors