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Showing 126 to 150 of 548 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
159 Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Evgeniia Kazymova BY-SA 279: Thyroperoxidase, Inhibition WPHA/WNT Endorsed 1.35
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Cataia Ives BY-SA 762: Activation, ionotropic GABA Receptor chloride channel 351: Increased Mortality
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Brendan Ferreri-Hanberry BY-SA 1018: Activation, Glutamate-gated chloride channels 351: Increased Mortality
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Arthur Author BY-SA None 741: Increase, Adenomas/carcinomas (follicular cell)
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Agnes Aggy BY-SA 1028: Activation of specific nuclear receptors, PPAR-gamma activation None
164 Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Allie Always BY-SA 1038: Activation, beta-2 adrenergic receptor 1044: Promotion, mesovarian leiomyomas
165 Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Evgeniia Kazymova BY-SA None
166 PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Cataia Ives BY-SA None 1063: Increased, Pancreatic acinar tumors
167 Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells Brendan Ferreri-Hanberry BY-SA 111: Agonism, Estrogen receptor 1070: Increased, adenosquamous carcinomas of endometrium
168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Arthur Author BY-SA None 1079: Increased, Adenomas/carcinomas (mammary)
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Agnes Aggy BY-SA None 1082: Increased, adenomas (pituitary)
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Allie Always BY-SA None 1079: Increased, Adenomas/carcinomas (mammary)
171 Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Evgeniia Kazymova BY-SA None 1090: Increased, mesotheliomas
173 Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis Cataia Ives All rights reserved 1495: Substance interaction with the lung resident cell membrane components 1458: Pulmonary fibrosis WPHA/WNT Endorsed 1.32
175 Thyroperoxidase inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry BY-SA 279: Thyroperoxidase, Inhibition 1101: Altered, Amphibian metamorphosis
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Arthur Author BY-SA 424: Inhibition, Na+/I- symporter (NIS) 1101: Altered, Amphibian metamorphosis
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Agnes Aggy BY-SA 1103: Inhibition, Cyclooxygenase 1 activity
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Allie Always BY-SA 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
179 Varroa mite infestation increases virus levels leading to colony loss/failure Evgeniia Kazymova BY-SA None 563: Death/Failure, Colony
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Cataia Ives BY-SA None 563: Death/Failure, Colony
181 Weather event contributes to colony loss/failure Brendan Ferreri-Hanberry BY-SA None 563: Death/Failure, Colony
182 Weather event contributes abnormal foraging leading to colony loss/failure Arthur Author BY-SA None 563: Death/Failure, Colony
183 Nosema infection increases energetic demands leading to colony loss/failure Agnes Aggy BY-SA None 563: Death/Failure, Colony
184 Nosema infection causes abnormal role change that leads to colony loss/failure Allie Always BY-SA None 563: Death/Failure, Colony
185 Queen egg-laying decrease leads to colony loss/failure Evgeniia Kazymova BY-SA None 563: Death/Failure, Colony