AOP-Wiki

All AOPs

Showing 151 to 175 of 548 AOPs

ID	Title	Point of Contact	License	MIE	AO	OECD Status	OECD Project

186	unknown MIE leading to renal failure and mortality	Cataia Ives	BY-SA	1114: Unknown, MIE	351: Increased Mortality
187	Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage	Brendan Ferreri-Hanberry	BY-SA	3 MIEs 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone 1138: Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP 1169: Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin	1136: Impaired recruitment , Population trajectory	Under Development	1.31
188	Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis	Arthur Author	BY-SA	1152: Inhibition, Iodotyrosine deiodinase (IYD)	1101: Altered, Amphibian metamorphosis
189	Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis	Agnes Aggy	BY-SA	1009: Inhibition, Deiodinase 1	1101: Altered, Amphibian metamorphosis
190	Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis	Allie Always	BY-SA	1002: Inhibition, Deiodinase 2	1101: Altered, Amphibian metamorphosis
191	Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis	Evgeniia Kazymova	BY-SA	1153: Inhibition, Deiodinase 3	1101: Altered, Amphibian metamorphosis
192	Pendrin inhibition leading to altered amphibian metamorphosis	Cataia Ives	BY-SA	1155: Inhibition, Pendrin	1101: Altered, Amphibian metamorphosis
193	Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis	Brendan Ferreri-Hanberry	BY-SA	1156: Inhibition, Dual oxidase	1101: Altered, Amphibian metamorphosis
194	Hepatic nuclear receptor activation leading to altered amphibian metamorphosis	Arthur Author	BY-SA	1157: Activation, Hepatic nuclear receptor(s)	1101: Altered, Amphibian metamorphosis
195	5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase	Agnes Aggy	BY-SA	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	1164: Increased, Population
196	Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation	Allie Always	BY-SA	1215: TRPA1 activation, TRPA1 Receptor	3 AOs 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea 1434: Irritation of nasal mucosa inducing sneeze reflex 1226: Increased Respiratory irritability and Chronic Cough,
197	Sodium channel (Nav1.1) inhibition leading to population decline	Evgeniia Kazymova	BY-SA	584: Inhibition, sodium channel	None
199	ER mediated breast cancer AOP	Cataia Ives	BY-SA	None	None
200	Estrogen receptor activation leading to breast cancer	Brendan Ferreri-Hanberry	Open for adoption	111: Agonism, Estrogen receptor	1193: N/A, Breast Cancer
201	Juvenile hormone receptor agonism leading to male offspring induction associated population decline	Arthur Author	BY-SA	1205: Activation, Juvenile hormone receptor	3 AOs 1208: Increased, Male offspring 361: Decline, Population 1210: Alteration, Food-web structures
202	Inhibitor binding to topoisomerase II leading to infant leukaemia	Agnes Aggy	BY-SA	1252: Binding to (interferes with) topoisomerase II enzyme	1254: Infant leukaemia	WPHA/WNT Endorsed	1.53
203	5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline	Allie Always	BY-SA	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	2 AOs 1141: Decreased, Reproductive Success 360: Decrease, Population growth rate
204	5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase	Evgeniia Kazymova	BY-SA	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	2 AOs 1163: Increased, Reproductive Success 1164: Increased, Population
205	AOP from chemical insult to cell death	Cataia Ives	BY-SA	3 MIEs 1258: Decompartmentalization 1260: Direct mitochondrial inhibition 1259: narcosis	2 AOs 1262: Apoptosis 1263: Necrosis
206	Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis	Brendan Ferreri-Hanberry	All rights reserved	1270: Inactivation of PPARγ	1276: Lung fibrosis	Under Development	1.54
207	NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans	Arthur Author	All rights reserved	1174: Activation, NADPH Oxidase	1277: Reproductive failure
208	Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure	Agnes Aggy	All rights reserved	None	1277: Reproductive failure
209	Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP	Allie Always	All rights reserved	None	1291: Hepatotoxicity
210	Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building	Evgeniia Kazymova	All rights reserved	None	1277: Reproductive failure
211	Handbook development AOP	Cataia Ives	BY-SA	None	None