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All KERs

Showing 426 to 450 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2391	752: Altered, Meiotic chromosome dynamics	1550: Ionizing Energy	May 12, 2021	May 12, 2021	None
2554	752: Altered, Meiotic chromosome dynamics	1965: Increase, Pollen abnormal	Jan 21, 2022	Jan 21, 2022	1 AOP 435: Deposition of ionising energy leads to population decline via pollen abnormal
203	186: Altered, Neuroanatomy	192: Altered, Neurophysiology	Nov 29, 2016	Nov 29, 2016	1 AOP 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
384	192: Altered, Neurophysiology	402: Cognitive function, decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
2789	2067: Altered, Nitric Oxide Levels	2068: Increase, Endothelial Dysfunction	Oct 20, 2022	Aug 26, 2024	1 AOP 470: Deposition of energy leads to abnormal vascular remodeling
1918	1640: Altered, Photoreceptor patterning	1643: Altered, Visual function	May 22, 2019	Jun 16, 2021	2 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
1303	1240: Altered, Protein Production	1189: Increased, Proliferation (Endothelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1304	1240: Altered, Protein Production	1183: Decreased, Apoptosis (Epithelial Cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1305	1240: Altered, Protein Production	1241: Increased, Motility	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
3266	1240: Altered, Protein Production	1392: Oxidative Stress	Jul 4, 2024	Jul 4, 2024	1 AOP 200: Estrogen receptor activation leading to breast cancer
3454	2299: Altered, Redox Homeostasis	178: Disruption, Mitochondrial electron transport chain	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2374	1877: Altered, retinal layer structure	1643: Altered, Visual function	May 11, 2021	Jul 8, 2022	1 AOP 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
2244	1829: Altered, TH-dependent gene expression	1101: Altered, Amphibian metamorphosis	Dec 9, 2020	Dec 9, 2020	1 AOP 191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
316	286: Altered, Transcription of genes by the AR	240: Feminisation or incomplete development, Primary and accessory male sex organs	Nov 29, 2016	Dec 3, 2016	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
317	286: Altered, Transcription of genes by the AR	310: Alteration, Wnt pathway	Nov 29, 2016	Dec 3, 2016	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
2127	286: Altered, Transcription of genes by the AR	1688: AGD, decreased	May 11, 2020	May 7, 2025	3 AOPs 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
2132	286: Altered, Transcription of genes by the AR	1786: nipple retention, increased	May 11, 2020	May 11, 2020	None
2273	286: Altered, Transcription of genes by the AR	1800: Reduced granulosa cell proliferation	Jan 28, 2021	Mar 18, 2025	1 AOP 345: Androgen receptor (AR) antagonism leading to decreased fertility in females
2909	286: Altered, Transcription of genes by the AR	2134: Increase, AR protein expression/abundance	May 11, 2023	May 11, 2023	1 AOP 495: Androgen receptor activation leading to prostate cancer
1919	1643: Altered, Visual function	361: Decline, Population	May 22, 2019	May 22, 2019	None
2143	1643: Altered, Visual function	360: Decrease, Population growth rate	May 25, 2020	May 25, 2020	1 AOP 297: Inhibition of retinaldehyde dehydrogenase leads to population decline
2375	1643: Altered, Visual function	351: Increased Mortality	May 11, 2021	Jul 8, 2022	4 AOPs 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
3192	2108: Altered, white brain matter	341: Impairment, Learning and memory	Apr 12, 2024	Apr 12, 2024	2 AOPs 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
3667	2108: Altered, white brain matter	2231: Impaired locomotor function	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1970	1673: Alveolar collapse	1674: Alveolar reopening	Jul 3, 2019	Jul 3, 2019	None

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