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All KERs

Showing 501 to 525 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3468	1262: Apoptosis	1883: Decreased, ovarian reserve	Jan 4, 2025	May 31, 2025	1 AOP 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
2198	1817: Apoptotic cell death	1633: Increase in inflammation	Nov 2, 2020	Nov 2, 2020	1 AOP 362: Immune mediated hepatitis
3436	2293: Aromatase, induction	1076: Increased, circulating estrogen levels	Nov 22, 2024	Dec 16, 2024	1 AOP 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
2192	1814: Reactive Metabolite	1816: Mitochondrial dysfunction EMPTY	Nov 2, 2020	Nov 2, 2020	None
2194	1814: Reactive Metabolite	1818: Immune cell activation	Nov 2, 2020	Nov 2, 2020	1 AOP 362: Immune mediated hepatitis
3151	1814: Reactive Metabolite	177: Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 362: Immune mediated hepatitis
3199	1755: beta-catenin activation	1457: EMT	Apr 23, 2024	Apr 23, 2024	1 AOP 298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
248	214: Bile accumulation, Pathological condition	288: Activation of specific nuclear receptors, Transcriptional change	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
928	214: Bile accumulation, Pathological condition	87: Release, Cytokine	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
3510	214: Bile accumulation, Pathological condition	1115: Increase, ROS	Apr 3, 2025	Apr 3, 2025	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
877	857: Binding as antagonist, Antagonist binding to PPARalpha ligand binding domain	858: Decreased, PPARalpha transactivation of gene expression	Nov 29, 2016	Nov 29, 2016	None
666	667: Binding at picrotoxin site, iGABAR chloride channel	64: Reduction, Ionotropic GABA receptor chloride channel conductance	Nov 29, 2016	Apr 29, 2019	1 AOP 10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
3183	2218: Binding of (ant)agonist to liver X receptor	2221: LXR activity, altered	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3187	2218: Binding of (ant)agonist to liver X receptor	2115: Cholesterol metabolism	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3184	2219: Binding of (ant)agonist to PPAR alpha	2216: Binding of antagonist to thyroid hormone receptor	Apr 12, 2024	Apr 12, 2024	None
3185	2219: Binding of (ant)agonist to PPAR alpha	2222: PPAR alpha activity, altered	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3188	2219: Binding of (ant)agonist to PPAR alpha	2115: Cholesterol metabolism	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3195	2219: Binding of (ant)agonist to PPAR alpha	2223: Reduced number of oligodendrocytes	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2319	1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)	1115: Increase, ROS	Apr 10, 2021	Apr 10, 2021	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis
919	875: Binding of agonist, Ionotropic glutamate receptors	388: Overactivation, NMDARs	Nov 29, 2016	Nov 29, 2016	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
3506	875: Binding of agonist, Ionotropic glutamate receptors	2078: Loss of drebrin	Mar 9, 2025	Mar 9, 2025	1 AOP 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
360	387: Binding of agonist, NMDARs	388: Overactivation, NMDARs	Nov 29, 2016	Nov 29, 2016	None
3182	2217: Binding of antagonist to glucocorticoid hormone receptor	2220: GR antagonism	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3181	2216: Binding of antagonist to thyroid hormone receptor	1656: TR Antagnoism	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
228	201: Binding of antagonist, NMDA receptors	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	None

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