Key Event Relationships (KERs)

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Showing 551 to 575 of 3002 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1683 1487: Binding, SH/SeH proteins involved in protection against oxidative stress 177: Mitochondrial dysfunction Nov 9, 2017 Nov 9, 2017 None
1689 1487: Binding, SH/SeH proteins involved in protection against oxidative stress 1392: Oxidative Stress Nov 9, 2017 Feb 7, 2018 None
1765 1487: Binding, SH/SeH proteins involved in protection against oxidative stress 1538: Protection against oxidative stress, decreased Sep 13, 2018 Feb 10, 2020
2250 1831: Binding, Thyroid binding globulin in serum 1830: Displacement, Serum thyroxine (T4) from carrier protein Dec 9, 2020 Dec 9, 2020
2245 957: Binding, Transthyretin in serum 958: Displacement, Serum thyroxine (T4) from transthyretin Dec 9, 2020 Dec 9, 2020
2248 957: Binding, Transthyretin in serum 1830: Displacement, Serum thyroxine (T4) from carrier protein Dec 9, 2020 Dec 9, 2020
2269 957: Binding, Transthyretin in serum 961: Increased, Clearance of thyroxine from serum Jan 26, 2021 Jan 26, 2021 None
2271 957: Binding, Transthyretin in serum 959: Increased, Free serum thyroxine (T4) Jan 26, 2021 Jan 26, 2021 None
714 718: Binding, Tubulin 720: Disruption, Microtubule dynamics Nov 29, 2016 May 27, 2019
724 718: Binding, Tubulin 723: Altered, Chromosome number Nov 29, 2016 Dec 13, 2019
330 301: Binding, VEGF-A 304: Decreased, VegfR2 Nov 29, 2016 Dec 3, 2016 None
331 301: Binding, VEGF-A 305: Inhibition, VegfR2 Nov 29, 2016 Dec 3, 2016 None
2025 1716: STAT5 inhibition 1717: Suppression of STAT5 binding to cytokine gene promoters Jan 5, 2020 Nov 3, 2021
1755 1529: Blockade, L-Type Calcium Channels 1530: Decrease, Calcium currents Jun 19, 2018 Jun 19, 2018
3406 1529: Blockade, L-Type Calcium Channels 698: Altered, Action Potential Nov 20, 2024 Nov 20, 2024
1813 1570: Blocking of IL-1R 1572: Impaired IL-1 signaling Dec 24, 2018 Jun 25, 2019 None
1973 1676: Blood extravasation into the lungs 1679: Acute inhalation toxicity Jul 3, 2019 Jul 3, 2019 None
1170 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tis 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction Nov 29, 2016 Dec 3, 2016
2353 1867: Bradykinin, activated 1496: Increased proinflammatory mediators Apr 20, 2021 Jan 14, 2022
2355 1867: Bradykinin, activated 1866: Hypofibrinolysis Apr 20, 2021 Jan 24, 2022
2357 1867: Bradykinin, activated 1868: Hyperinflammation Apr 20, 2021 Oct 19, 2021
3654 2093: Decreased brain T4/T3 1656: TR Antagnoism Oct 8, 2025 Oct 8, 2025
3658 2093: Decreased brain T4/T3 381: BDNF, Reduced Oct 8, 2025 Oct 8, 2025
2398 1879: Bulky DNA adducts, increase 155: Inadequate DNA repair May 17, 2021 May 17, 2021
2399 1879: Bulky DNA adducts, increase 185: Increase, Mutations May 17, 2021 Sep 14, 2021