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Showing 676 to 700 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2205	1821: Decrease, Cell proliferation	1521: Decrease, Growth	Nov 12, 2020	Jul 6, 2022	9 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
2405	1821: Decrease, Cell proliferation	1878: Decreased, Eye size	May 28, 2021	Aug 7, 2021	1 AOP 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
2724	1821: Decrease, Cell proliferation	2041: Decrease, facial prominence outgrowth	Jul 28, 2022	Apr 2, 2025	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
3586	1821: Decrease, Cell proliferation	2348: Inhibition, Liver regeneration	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBEPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
2755	2060: Decrease, Chitin laminar organization	2062: Weak, Procuticle protection	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
1665	1473: Decrease, Chlorophyll synthesis	1474: Decrease, Light harvest capacity	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1347	1266: Decrease, Circulating CCAP	1267: Decrease, Ecdysis motor program activity	Feb 9, 2017	Feb 9, 2017	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
1000	988: Decrease, Circulating ETH	990: Increase, Incomplete ecdysis	Nov 29, 2016	Dec 3, 2016	None
1008	988: Decrease, Circulating ETH	993: Decrease, Abdominal muscle contraction	Nov 29, 2016	Dec 3, 2016	None
1346	988: Decrease, Circulating ETH	1266: Decrease, Circulating CCAP	Feb 9, 2017	Feb 9, 2017	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
2126	1690: Decrease, circulating testosterone levels	1613: Decrease, DHT level	May 11, 2020	Oct 19, 2023	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
2131	1690: Decrease, circulating testosterone levels	1614: Decrease, AR activation	May 11, 2020	Apr 5, 2024	4 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
3169	1690: Decrease, circulating testosterone levels	2212: Epididymal agenesis	Mar 20, 2024	Dec 3, 2024	1 AOP 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
3202	1690: Decrease, circulating testosterone levels	809: malformed, Male reproductive tract	Apr 25, 2024	Apr 25, 2024	1 AOP 124: HMG-CoA reductase inhibition leading to decreased fertility
3205	1690: Decrease, circulating testosterone levels	348: Malformation, Male reproductive tract	May 1, 2024	May 1, 2024	1 AOP 18: PPARα activation in utero leading to impaired fertility in males
3206	1690: Decrease, circulating testosterone levels	414: Increase, Luteinizing hormone (LH)	May 1, 2024	May 1, 2024	1 AOP 51: PPARα activation leading to impaired fertility in adult male rodents
3213	1690: Decrease, circulating testosterone levels	219: Reduction, Plasma 17beta-estradiol concentrations	May 8, 2024	May 8, 2024	1 AOP 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
3214	1690: Decrease, circulating testosterone levels	2139: Reduction, the ratio of E2/11-KT in plasma	May 8, 2024	May 8, 2024	1 AOP 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
3225	1690: Decrease, circulating testosterone levels	520: Decreased sperm quantity or quality in the adult, Decreased fertility	May 24, 2024	May 24, 2024	1 AOP 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
3227	1690: Decrease, circulating testosterone levels	791: Increased, Leutinizing hormone (LH)	May 24, 2024	May 24, 2024	1 AOP 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
3349	1690: Decrease, circulating testosterone levels	1688: AGD, decreased	Oct 1, 2024	May 6, 2025	1 AOP 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
3350	1690: Decrease, circulating testosterone levels	2082: Hypospadias	Oct 1, 2024	Sep 18, 2025	1 AOP 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring
3486	1690: Decrease, circulating testosterone levels	1786: nipple retention, increased	Jan 30, 2025	Sep 17, 2025	1 AOP 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
3620	1690: Decrease, circulating testosterone levels	1758: Impaired, Spermatogenesis	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Nanoplastic effect
1600	1446: Decrease, Coupling of OXPHOS	40: Decrease, Mitochondrial ATP production	Jun 29, 2017	Jun 29, 2017	None

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