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All KERs

Showing 1051 to 1075 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2838	1686: Energy Deposition	341: Impairment, Learning and memory	Jan 25, 2023	Jul 26, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2847	1686: Energy Deposition	2089: Altered Bone Cell Homeostasis	Jan 25, 2023	Aug 9, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2848	1686: Energy Deposition	2090: Bone Remodeling	Jan 25, 2023	Aug 9, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2849	1686: Energy Deposition	2091: Bone Loss	Jan 25, 2023	Aug 12, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
1798	1550: Ionizing Energy	1553: Increase mutations	Dec 19, 2018	Dec 19, 2018	None
1799	1550: Ionizing Energy	1554: Increase chromosomal aberrations	Dec 19, 2018	Dec 19, 2018	None
2379	1550: Ionizing Energy	1115: Increase, ROS	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2380	1550: Ionizing Energy	1194: Increase, DNA Damage	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2392	1550: Ionizing Energy	752: Altered, Meiotic chromosome dynamics	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2393	1550: Ionizing Energy	1798: Decreased spermatogenesis	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2394	1550: Ionizing Energy	406: decreased, Fertility	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2395	1550: Ionizing Energy	1696: Decrease of egg production and cummulative fecundity	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2396	1550: Ionizing Energy	997: Decreased, Population size	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2397	1550: Ionizing Energy	1775: Increase, Oocyte apoptosis	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
3240	1550: Ionizing Energy	1392: Oxidative Stress	May 31, 2024	May 31, 2024	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
659	663: Desensitization, Nicotinic acetylcholine receptor	386: Neuronal network function, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
1309	663: Desensitization, Nicotinic acetylcholine receptor	1243: Altered, Ca2+-calmodulin activated signal transduction	Nov 29, 2016	Dec 3, 2016	2 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
1356	1272: Differentiation of Myofibroblast	1274: Production of α-smooth muscle actin	Feb 15, 2017	Feb 15, 2017	None
3381	2273: Dihydrotestosterone (DHT) levels, increased	2274: Androgen receptor activation, increased	Nov 2, 2024	Nov 24, 2024	None
973	944: dimerization, AHR/ARNT	945: reduced dimerization, ARNT/HIF1-alpha	Nov 29, 2016	Mar 23, 2018	2 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 151: AhR activation leading to preeclampsia
1350	944: dimerization, AHR/ARNT	1269: Increase, COX-2 expression	Feb 9, 2017	May 9, 2017	1 AOP 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
1996	944: dimerization, AHR/ARNT	1697: Increase, DNMT expression	Oct 30, 2019	Oct 30, 2019	1 AOP 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
2682	944: dimerization, AHR/ARNT	2020: Decrease, sox9 expression	Jun 30, 2022	Jun 30, 2022	None
2683	944: dimerization, AHR/ARNT	2021: Increase, slincR expression	Jun 30, 2022	Sep 8, 2022	2 AOPs 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
3466	944: dimerization, AHR/ARNT	2124: increased, Bax	Jan 4, 2025	May 27, 2025	1 AOP 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis

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