AOP-Wiki

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All KERs

Showing 1426 to 1450 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

355	55: Cell injury/death	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
364	55: Cell injury/death	352: N/A, Neurodegeneration	Nov 29, 2016	Sep 10, 2023	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
365	55: Cell injury/death	188: Neuroinflammation	Nov 29, 2016	Jul 15, 2022	3 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
924	55: Cell injury/death	87: Release, Cytokine	Nov 29, 2016	Nov 9, 2018	None
1688	55: Cell injury/death	386: Neuronal network function, Decreased	Nov 9, 2017	Feb 5, 2020	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1718	55: Cell injury/death	1492: Tissue resident cell activation	Feb 1, 2018	Aug 2, 2018	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 38: Protein Alkylation leading to Liver Fibrosis
1776	55: Cell injury/death	1493: Increased pro-inflammatory mediators	Nov 12, 2018	Nov 12, 2018	1 AOP 144: Endocytic lysosomal uptake leading to liver fibrosis
1830	55: Cell injury/death	1548: Necrotic Tissue	Jan 7, 2019	Mar 7, 2019	2 AOPs 278: IKK complex inhibition leading to liver injury 273: Mitochondrial complex inhibition leading to liver injury
1831	55: Cell injury/death	1576: Activation, Tissue resident cells (Kuppfer cells)	Jan 7, 2019	Jan 7, 2019	1 AOP 278: IKK complex inhibition leading to liver injury
1863	55: Cell injury/death	1514: Neurodegeneration	Feb 19, 2019	Feb 19, 2019	None
2767	55: Cell injury/death	1521: Decrease, Growth	Sep 27, 2022	Sep 27, 2022	8 AOPs 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death
2875	55: Cell injury/death	758: Hippocampal Physiology, Altered	Apr 5, 2023	Apr 5, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
2890	55: Cell injury/death	1494: Leukocyte recruitment/activation	Apr 13, 2023	Apr 13, 2023	None
3197	55: Cell injury/death	1931: Disruption of the intestinal barrier	Apr 17, 2024	Apr 17, 2024	1 AOP 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
3198	55: Cell injury/death	177: Mitochondrial dysfunction	Apr 17, 2024	Apr 17, 2024	None
3244	55: Cell injury/death	2084: Increase, Cardiac remodelling	Jun 4, 2024	Jun 4, 2024	1 AOP 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
3245	55: Cell injury/death	1532: Decrease, Cardiac contractility	Jun 4, 2024	Jun 4, 2024	1 AOP 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
1746	1527: Increase, Cell membrane depolarization	1526: Increase, Opening of voltage-dependent calcium channel	May 24, 2018	May 24, 2018	1 AOP 361: Sulfonylureareceptor binding leading to mortality
2708	1527: Increase, Cell membrane depolarization	389: Increased, Intracellular Calcium overload	Jul 25, 2022	Jul 25, 2022	None
2788	1527: Increase, Cell membrane depolarization	55: Cell injury/death	Oct 19, 2022	Oct 19, 2022	1 AOP 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
3039	1527: Increase, Cell membrane depolarization	2187: Opening VGCCs	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
890	870: Increase, Cell Proliferation	376: Increased, Induced Mutations in Critical Genes	Nov 29, 2016	Dec 3, 2016	None
893	870: Increase, Cell Proliferation	876: Increase, Mutations in Critical Genes	Nov 29, 2016	Dec 3, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
895	870: Increase, Cell Proliferation	872: Increase, Site of Contact Nasal Tumors	Nov 29, 2016	Dec 1, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
1967	870: Increase, Cell Proliferation	1670: Lung cancer	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 451: Interaction with lung resident cell membrane components leads to lung cancer

Key Event Relationships (KERs)

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