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All KERs

Showing 151 to 175 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1438	1336: Activation, 5-HT2A	1337: Activate, PLC	Apr 14, 2017	Apr 14, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
750	9: Activation, 5HT2c	294: N/A, Unknown	Nov 29, 2016	Dec 3, 2016	1 AOP 33: Kidney toxicity induced by activation of 5HT2C
18	18: Activation, AhR	17: Altered expression of AHR/ARNT pathway-dependent genes	Nov 29, 2016	Dec 3, 2016	None
19	18: Activation, AhR	80: Up Regulation, CYP1A1	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
473	18: Activation, AhR	451: Inhibition, Mitochondrial fatty acid beta-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
495	18: Activation, AhR	54: Up Regulation, CD36	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
496	18: Activation, AhR	465: Increased, FA Influx	Nov 29, 2016	Dec 3, 2016	None
499	18: Activation, AhR	216: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
506	18: Activation, AhR	466: Up Regulation, LDLR (low density lipoprotein receptor)	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
509	18: Activation, AhR	450: Suppression, VLDL secretion	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
869	18: Activation, AhR	850: Induction, CYP1A2/CYP1A5	Nov 29, 2016	May 7, 2018	2 AOPs 131: Aryl hydrocarbon receptor activation leading to uroporphyria 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
972	18: Activation, AhR	944: dimerization, AHR/ARNT	Nov 29, 2016	Mar 22, 2018	7 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 151: AhR activation leading to preeclampsia 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
984	18: Activation, AhR	947: Increase, Early Life Stage Mortality	Nov 29, 2016	Apr 14, 2019	4 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
1656	18: Activation, AhR	462: Up Regulation, SCD-1	Aug 31, 2017	Aug 31, 2017	1 AOP 57: AhR activation leading to hepatic steatosis
1992	18: Activation, AhR	1697: Increase, DNMT expression	Oct 30, 2019	Oct 30, 2019	None
2568	18: Activation, AhR	149: Increase, Inflammation	Feb 15, 2022	Mar 5, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2569	18: Activation, AhR	1262: Apoptosis	Feb 15, 2022	Dec 20, 2022	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2570	18: Activation, AhR	1241: Increased, Motility	Feb 15, 2022	Feb 29, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2571	18: Activation, AhR	1190: Increased, Migration (Endothelial Cells)	Feb 15, 2022	Feb 29, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2572	18: Activation, AhR	1196: Increased, Invasion	Feb 15, 2022	Mar 5, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2687	18: Activation, AhR	2021: Increase, slincR expression	Jun 30, 2022	Jun 30, 2022	None
2688	18: Activation, AhR	2020: Decrease, sox9 expression	Jun 30, 2022	Apr 13, 2023	2 AOPs 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
2689	18: Activation, AhR	1559: Smaller and morphologically distorted facial cartilage structures	Jun 30, 2022	Apr 13, 2023	1 AOP 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
2765	18: Activation, AhR	317: Altered, Cardiovascular development/function	Sep 27, 2022	Oct 21, 2022	1 AOP 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
2883	18: Activation, AhR	295: Induction, Upregulation of glucuronyltransferase activity	Apr 12, 2023	Apr 12, 2023	1 AOP 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals

Key Event Relationships (KERs)

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