AOP-Wiki

API

All KERs

Showing 1826 to 1850 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1954	1662: plasma homocysteine increases	1663: brain Homocysteine level increases	Jun 14, 2019	Jun 14, 2019	None
2902	2132: Increased cytokine expression	1633: Increase in inflammation	May 4, 2023	May 4, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1719	1493: Increased pro-inflammatory mediators	55: Cell injury/death	Feb 1, 2018	Feb 12, 2018	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1764	1493: Increased pro-inflammatory mediators	265: Activation, Stellate cells	Aug 2, 2018	Aug 2, 2018	1 AOP 38: Protein Alkylation leading to Liver Fibrosis
1777	1493: Increased pro-inflammatory mediators	1494: Leukocyte recruitment/activation	Nov 12, 2018	Nov 12, 2018	3 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1902	1493: Increased pro-inflammatory mediators	1193: N/A, Breast Cancer	May 7, 2019	May 10, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1903	1493: Increased pro-inflammatory mediators	1632: Increase in RONS	May 7, 2019	May 9, 2019	2 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1908	1493: Increased pro-inflammatory mediators	1182: Increase, Cell Proliferation (Epithelial Cells)	May 10, 2019	May 10, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
2777	1493: Increased pro-inflammatory mediators	2068: Increase, Endothelial Dysfunction	Sep 28, 2022	Aug 26, 2024	1 AOP 470: Deposition of energy leads to abnormal vascular remodeling
1770	1226: Respiratory irritability	1223: Increased Airway Hyper-responsiveness,Cough, Dyspnea	Sep 24, 2018	Sep 24, 2018	1 AOP 196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
2291	1847: SARS-CoV-2 production	1392: Oxidative Stress	Mar 25, 2021	Mar 25, 2021	None
2351	1847: SARS-CoV-2 production	1848: TLR Activation/Dysregulation	Apr 16, 2021	Apr 16, 2021	1 AOP 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
2358	1847: SARS-CoV-2 production	1869: Diminished Protective Response to ROS	Apr 20, 2021	Sep 26, 2023	2 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 406: SARS-CoV-2 infection leading to hyperinflammation
2488	1847: SARS-CoV-2 production	1825: Increase, Cell death	Oct 19, 2021	Oct 19, 2021	1 AOP 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2498	1847: SARS-CoV-2 production	1939: Viral infection, proliferated	Oct 24, 2021	Jun 29, 2024	1 AOP 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
2545	1847: SARS-CoV-2 production	1870: Sustentacular cells, decrease	Jan 5, 2022	Jan 5, 2022	1 AOP 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
2546	1847: SARS-CoV-2 production	1931: Disruption of the intestinal barrier	Jan 5, 2022	Jun 14, 2022	1 AOP 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption
2329	1855: Increased Sodium-sensitive hypertension	1603: Chronic kidney disease	Apr 10, 2021	Apr 10, 2021	1 AOP 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
2698	2033: Increased S1-P	1502: Histone deacetylase inhibition	Jul 19, 2022	Jul 19, 2022	1 AOP 449: Ceramide synthase inhibition leading to neural tube defects
1592	1441: Systemic cholesterol increased	1442: Foam cell formation	Jun 29, 2017	Jun 29, 2017	None
3418	2285: the delayed and early afterdepolarizations	1106: Occurrence, cardiac arrhythmia	Nov 21, 2024	Nov 21, 2024	1 AOP 554: β-adrenergic receptor agonists leading to arrhythmias.
3412	2283: Early premature depolarizations	1929: Increased incidence of cardiovascular morbidity and mortality	Nov 21, 2024	Nov 21, 2024	1 AOP 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
3421	2283: Early premature depolarizations	1535: Heart failure	Nov 21, 2024	Nov 21, 2024	1 AOP 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
3409	2281: uncoordinated cardiac contraction	1929: Increased incidence of cardiovascular morbidity and mortality	Nov 20, 2024	Nov 20, 2024	None
3447	2281: uncoordinated cardiac contraction	1535: Heart failure	Nov 27, 2024	Nov 27, 2024	1 AOP 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)

Key Event Relationships (KERs)

All KERs