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All KERs

Showing 2276 to 2300 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

804	804: Inhibition, HMG-CoA reductase	805: Decreased, mevalonate	Nov 29, 2016	Dec 3, 2016	1 AOP 124: HMG-CoA reductase inhibition leading to decreased fertility
1827	1574: Inhibition, IKK complex	202: Inhibition, Nuclear factor kappa B (NF-kB)	Jan 7, 2019	Mar 7, 2019	1 AOP 278: IKK complex inhibition leading to liver injury
159	147: Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307	270: Induction, Sustained Hepatotoxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
1197	1152: Inhibition, Iodotyrosine deiodinase (IYD)	425: Thyroidal Iodide, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
2476	1152: Inhibition, Iodotyrosine deiodinase (IYD)	281: T4 in serum, Decreased	Sep 9, 2021	Sep 9, 2021	1 AOP 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
3587	2348: Inhibition, Liver regeneration	2019: Non-alcoholic fatty liver disease	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBEPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
1413	1307: Inhibition, LXR	468: Inhibition, PPAR alpha	Apr 12, 2017	Apr 12, 2017	None
1781	1542: Inhibition, Mitochondrial complex III	1545: Decrease in mitochondrial oxidative phosphorylation	Dec 19, 2018	Mar 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
1872	1542: Inhibition, Mitochondrial complex III	1477: Decrease, OXPHOS	Mar 19, 2019	Mar 19, 2019	None
2230	1542: Inhibition, Mitochondrial complex III	1771: Decrease, ATP pool	Dec 4, 2020	Dec 4, 2020	1 AOP 286: Mitochondrial complex III antagonism leading to growth inhibition (1)
3637	1542: Inhibition, Mitochondrial complex III	177: Mitochondrial dysfunction	Sep 24, 2025	Oct 2, 2025	1 AOP 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits
2636	105: Inhibition, ETC complexes of the respiratory chain	1770: Decrease, MMP	Apr 8, 2022	Apr 8, 2022	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
2821	105: Inhibition, ETC complexes of the respiratory chain	177: Mitochondrial dysfunction	Jan 5, 2023	Jan 5, 2023	2 AOPs 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
3241	105: Inhibition, ETC complexes of the respiratory chain	1392: Oxidative Stress	May 31, 2024	May 31, 2024	1 AOP 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
475	451: Inhibition, Mitochondrial fatty acid beta-oxidation	327: Accumulation, Fatty acid	Nov 29, 2016	Dec 3, 2016	2 AOPs 57: AhR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis
538	451: Inhibition, Mitochondrial fatty acid beta-oxidation	459: Increased, Liver Steatosis	Nov 29, 2016	Dec 3, 2016	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
3638	2258: Inhibition, monocarboxylate transporter 8 (MCT8)	280: T4 in neuronal tissue, Decreased	Sep 29, 2025	Sep 29, 2025	None
3651	2258: Inhibition, monocarboxylate transporter 8 (MCT8)	2093: Decreased brain T4/T3	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1049	1013: Inhibition, Motor neuron activity	1014: Induction, Somatic muscle paralysis	Nov 29, 2016	Dec 3, 2016	None
442	424: Inhibition, Na+/I- symporter (NIS)	425: Thyroidal Iodide, Decreased	Nov 29, 2016	May 29, 2018	3 AOPs 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
552	424: Inhibition, Na+/I- symporter (NIS)	277: TH synthesis, Decreased	Nov 29, 2016	Dec 3, 2016	2 AOPs 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
1503	424: Inhibition, Na+/I- symporter (NIS)	341: Impairment, Learning and memory	May 10, 2017	Apr 4, 2019	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
2232	424: Inhibition, Na+/I- symporter (NIS)	281: T4 in serum, Decreased	Dec 9, 2020	Dec 9, 2020	1 AOP 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
934	887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)	177: Mitochondrial dysfunction	Nov 29, 2016	Oct 3, 2025	1 AOP 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
1809	887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)	1477: Decrease, OXPHOS	Dec 20, 2018	Dec 20, 2018	1 AOP 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome

Key Event Relationships (KERs)

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