Key Event Relationships (KERs)

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Showing 2651 to 2675 of 3002 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1608 228: demethylation, PPARg promoter 1028: Activation of specific nuclear receptors, PPAR-gamma activation Jul 24, 2017 Jul 24, 2017
1659 228: demethylation, PPARg promoter 465: Increased, FA Influx Aug 31, 2017 Aug 31, 2017
2988 228: demethylation, PPARg promoter 2165: Activation of PPAR Aug 20, 2023 Aug 20, 2023
1125 1086: persistent, cytotoxicity (pleura or peritoneum) 1087: Increased, inflammation Nov 29, 2016 Dec 3, 2016
3261 1086: persistent, cytotoxicity (pleura or peritoneum) 1392: Oxidative Stress Jul 3, 2024 Jul 3, 2024
1377 1289: Perturbation of cholesterol 1291: Hepatotoxicity Feb 15, 2017 Feb 15, 2017
3427 2288: Phosphodiesterase (PDE) 2284: Intracellular cAMP Nov 22, 2024 Nov 22, 2024 None
3445 2288: Phosphodiesterase (PDE) 693: Increased, cyclic adenosine monophosphate Nov 26, 2024 Nov 26, 2024
2151 1794: Pin-1 activation 1795: TGFbeta expression Jul 9, 2020 Jul 9, 2020
3438 2294: Plasma E2, increased 2251: Increased E2 availability Nov 22, 2024 Nov 22, 2024
2456 1914: Platelet activation, Increased 1857: Platelet-neutrophil interactions, Increased Aug 4, 2021 Aug 4, 2021
2458 1857: Platelet-neutrophil interactions, Increased 1916: Thromboinflammation, Increased Aug 4, 2021 Aug 4, 2021
2607 1979: Premature differentiation 1978: Microcephaly Mar 21, 2022 Mar 21, 2022 None
3107 1979: Premature differentiation 2200: decline, neural progenitor cells Jan 10, 2024 Jan 10, 2024
1211 1146: premature, Spawning 1164: Increased, Population Nov 29, 2016 Dec 3, 2016 None
1222 1146: premature, Spawning 1141: Decreased, Reproductive Success Nov 29, 2016 Dec 3, 2016 None
1179 1144: premature, spawning 1 1141: Decreased, Reproductive Success Nov 29, 2016 Dec 3, 2016 None
1283 1234: Production of nerve growth factor , Epithelial irritation 1222: SP (Substance P) release, Local increase of SP Nov 29, 2016 Dec 3, 2016 None
1358 1274: Production of α-smooth muscle actin 1276: Lung fibrosis Feb 15, 2017 Feb 15, 2017 None
93 77: Production, Critical Metabolites (CGA 330050 and CGA 265307) 164: Induction, Liver “Dysfunctional” Changes by CGA 330050 Nov 29, 2016 Dec 3, 2016
332 302: Production, VEGF-A 301: Binding, VEGF-A Nov 29, 2016 Dec 3, 2016 None
333 302: Production, VEGF-A 304: Decreased, VegfR2 Nov 29, 2016 Dec 3, 2016 None
69 57: Proliferation, Cell proliferation in the absence of cytotoxicity 142: Hyperplasia, Hyperplasia Nov 29, 2016 Dec 3, 2016
1105 1067: Proliferation/Clonal Expansion, aberrant basal-type cells 1068: Endometrial squamous metaplasia, Increase Nov 29, 2016 Dec 3, 2016 None
1082 1042: Proliferation/Clonal Expansion, smooth muscle 1043: Hypertrophy/hyperplasia, smooth muscle Nov 29, 2016 Dec 3, 2016