Key Event Relationships (KERs)

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Showing 251 to 275 of 3002 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
875 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 854: Alterations, Cellular proliferation / hyperplasia Nov 29, 2016 Nov 29, 2016
876 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 856: Formation, Hepatocellular and Bile duct tumors Nov 29, 2016 Nov 29, 2016
1425 1314: Activation, LRH-1 116: Activation, FAS Apr 13, 2017 Apr 13, 2017 None
173 167: Activation, LXR 54: Up Regulation, CD36 Nov 29, 2016 Dec 3, 2016
174 167: Activation, LXR 66: Activation, ChREBP Nov 29, 2016 Dec 3, 2016
175 167: Activation, LXR 116: Activation, FAS Nov 29, 2016 Dec 3, 2016
176 167: Activation, LXR 258: Activation, SCD-1 Nov 29, 2016 Dec 3, 2016
177 167: Activation, LXR 264: Activation, SREBP-1c Nov 29, 2016 Dec 3, 2016
479 167: Activation, LXR 457: Activation, SREBF1 Nov 29, 2016 Dec 3, 2016
490 167: Activation, LXR 463: Up Regulation, FAS Nov 29, 2016 Dec 3, 2016
491 167: Activation, LXR 462: Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
510 167: Activation, LXR 468: Inhibition, PPAR alpha Nov 29, 2016 Dec 3, 2016
516 167: Activation, LXR 470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) Nov 29, 2016 Dec 3, 2016
3103 167: Activation, LXR 2199: Increased, Expression of LXR activated genes Dec 7, 2023 Mar 29, 2024
1606 483: Activation, LXR alpha 458: Increased, De Novo FA synthesis Jul 18, 2017 Jul 18, 2017
3376 1198: Activation, Macrophages 1442: Foam cell formation Oct 30, 2024 Oct 30, 2024
3588 2345: Activation, MAPK 1293: Activation, FOXO Aug 16, 2025 Aug 16, 2025
3589 2345: Activation, MAPK 291: Accumulation, Triglyceride Aug 16, 2025 Aug 16, 2025
2862 1998: Microglia activation 188: Neuroinflammation Apr 3, 2023 Apr 3, 2023
3543 2331: Activation, MR 291: Accumulation, Triglyceride Jul 25, 2025 Jul 25, 2025
3549 2331: Activation, MR 2336: Increase, SREBF1 Jul 25, 2025 Jul 25, 2025
1395 1300: Activation, mTORC1 1302: Activation, L-FABP Apr 12, 2017 Apr 12, 2017 None
1396 1300: Activation, mTORC1 1303: Activation, HSD17B4 Apr 12, 2017 Apr 12, 2017 None
1399 1300: Activation, mTORC1 1301: Activation, SREBP-1 Apr 12, 2017 Apr 12, 2017 None
1392 1298: Activation, mTORC2 1299: Activation, AKT Apr 12, 2017 Apr 12, 2017 None