Key Event Relationships (KERs)

API

Fulltext search has been disabled for Key Event Relationships (KERs) at this time. If you need this feature, send an email to aopwiki@googlegroups.com

Queries Key Event Relationship (KER) titles
Filter by Upstream Key Event title
Filter by Downstream Key Event title
Filter by AOP title
Clear All Filters

Showing 301 to 325 of 3002 KERs

Clear Table Filters
ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2253 227: Activation, PPARα 719: Increase, hepatocellular adenomas and carcinomas Dec 31, 2020 Dec 31, 2020
340 380: Activation, Pre-MIE: Metabolism of AFB1 373: Formation, Pro-mutagenic DNA Adducts Nov 29, 2016 Dec 3, 2016 None
2482 239: Activation, Pregnane-X receptor, NR1l2 295: Induction, Upregulation of glucuronyltransferase activity Sep 14, 2021 Sep 14, 2021 None
3100 239: Activation, Pregnane-X receptor, NR1l2 54: Up Regulation, CD36 Nov 30, 2023 Mar 27, 2024
3365 239: Activation, Pregnane-X receptor, NR1l2 2268: Decreased, INSIG1 protein activity Oct 22, 2024 Feb 10, 2025
1480 1369: Activation, PTGS-1 1375: Increase, platelet aggregation Apr 17, 2017 Apr 17, 2017
1481 1369: Activation, PTGS-1 1374: Increase, mucosal blood flow Apr 17, 2017 Apr 17, 2017
1482 1369: Activation, PTGS-1 1373: Increase, mucous Apr 17, 2017 Apr 17, 2017
1483 1369: Activation, PTGS-1 1372: Increase, bicarbonate Apr 17, 2017 Apr 17, 2017
1478 1370: Activation, PTGS-2 1377: Decrease, leukocyte adherence Apr 17, 2017 Apr 17, 2017
1479 1370: Activation, PTGS-2 1376: Increase, angiogenesis Apr 17, 2017 Apr 17, 2017
518 245: Activation, PXR/SXR 471: Inhibition, FoxA2 Nov 29, 2016 Dec 3, 2016
526 245: Activation, PXR/SXR 462: Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
529 245: Activation, PXR/SXR 54: Up Regulation, CD36 Nov 29, 2016 Dec 3, 2016
284 258: Activation, SCD-1 89: Synthesis, De Novo Fatty Acid (FA) Nov 29, 2016 Dec 3, 2016
1404 258: Activation, SCD-1 1306: Increased, lipogenesis Apr 12, 2017 Apr 12, 2017 None
896 480: Activation, SHP 878: Inhibition, SREBP1c Nov 29, 2016 Dec 3, 2016
1409 480: Activation, SHP 227: Activation, PPARα Apr 12, 2017 Apr 12, 2017 None
1412 480: Activation, SHP 1307: Inhibition, LXR Apr 12, 2017 Apr 12, 2017 None
1414 480: Activation, SHP 1308: Inhibition, LRH-1 Apr 12, 2017 Apr 12, 2017 None
987 924: Activation, Sp1 962: Increase, Mucin production Nov 29, 2016 Aug 11, 2021 None
482 457: Activation, SREBF1 458: Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016 None
489 457: Activation, SREBF1 462: Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
1662 457: Activation, SREBF1 459: Increased, Liver Steatosis Aug 31, 2017 Aug 31, 2017
1397 1301: Activation, SREBP-1 1304: Activation, FXR Apr 12, 2017 Apr 12, 2017 None