| 1926 |
1647: GSK3beta inactivation |
1648: β-catenin activation |
May 29, 2019 |
May 29, 2019 |
None
|
| 2485 |
1647: GSK3beta inactivation |
1902: Repression of Gbx2 expression |
Oct 3, 2021 |
Dec 12, 2021 |
1 AOP
|
| 2533 |
1954: Gut dysbiosis |
1931: Disruption of the intestinal barrier |
Dec 2, 2021 |
Dec 2, 2021 |
None
|
| 2544 |
1954: Gut dysbiosis |
1497: Recruitment of inflammatory cells |
Dec 15, 2021 |
Dec 15, 2021 |
None
|
| 3440 |
2295: HCN Channel Inhibition |
2296: Reduced Pacemaker Activity in SA Node |
Nov 24, 2024 |
Nov 24, 2024 |
1 AOP
|
| 2508 |
1535: Heart failure |
1948: Upregulation of ACE2 |
Oct 28, 2021 |
Oct 28, 2021 |
None
|
| 2514 |
1535: Heart failure |
1946: Altered mechanotransduction properties of pericytes |
Oct 28, 2021 |
Oct 28, 2021 |
None
|
| 2825 |
1535: Heart failure |
350: Increase, Mortality |
Jan 5, 2023 |
Jan 5, 2023 |
None
|
| 1546 |
1412: Helicobacter pylori infection |
1384: Increase, ammonium (NH4+) |
Jun 2, 2017 |
Jun 2, 2017 |
1 AOP
|
| 1166 |
1133: Hemostasis, Depletion from blood of fully functional carboxylated clotting factors |
1122: Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failur |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 1514 |
1393: Hepatocytotoxicity |
1394: Sustained proliferation |
May 30, 2017 |
Jun 19, 2021 |
1 AOP
|
| 1517 |
1393: Hepatocytotoxicity |
1395: Liver Cancer |
May 30, 2017 |
May 1, 2020 |
1 AOP
|
| 2535 |
1957: hERG channel biogenesis interference |
1958: Direct hERG channel blockage |
Dec 13, 2021 |
Dec 13, 2021 |
None
|
| 2536 |
1957: hERG channel biogenesis interference |
1959: Induction of hERG trafficking defects |
Dec 13, 2021 |
Dec 13, 2021 |
None
|
| 2850 |
2099: hERG channel blockade |
2100: Inhibition of rapid delayed rectifying potassium current |
Jan 29, 2023 |
Jan 29, 2023 |
1 AOP
|
| 749 |
757: Hippocampal anatomy, Altered |
758: Hippocampal Physiology, Altered |
Nov 29, 2016 |
Jul 25, 2024 |
4 AOPs
|
| 747 |
756: Hippocampal gene expression, Altered |
757: Hippocampal anatomy, Altered |
Nov 29, 2016 |
Aug 11, 2018 |
3 AOPs
|
| 2886 |
756: Hippocampal gene expression, Altered |
758: Hippocampal Physiology, Altered |
Apr 12, 2023 |
Apr 12, 2023 |
2 AOPs
|
| 748 |
758: Hippocampal Physiology, Altered |
402: Cognitive function, decreased |
Nov 29, 2016 |
Jul 26, 2024 |
6 AOPs
|
| 2484 |
758: Hippocampal Physiology, Altered |
319: Loss, Cochlear function |
Sep 14, 2021 |
Sep 14, 2021 |
None
|
| 2864 |
758: Hippocampal Physiology, Altered |
341: Impairment, Learning and memory |
Apr 3, 2023 |
Apr 3, 2023 |
1 AOP
|
| 1710 |
1503: Histone acetylation, increase |
1504: p21 (CDKN1A) expression, increase |
Jan 21, 2018 |
Jul 25, 2018 |
None
|
| 1806 |
1503: Histone acetylation, increase |
1239: Altered, Gene Expression |
Dec 20, 2018 |
Dec 20, 2018 |
1 AOP
|
| 1997 |
1503: Histone acetylation, increase |
1505: Cell cycle, disrupted |
Nov 11, 2019 |
Jul 1, 2021 |
1 AOP
|
| 1709 |
1502: Histone deacetylase inhibition |
1503: Histone acetylation, increase |
Jan 21, 2018 |
Aug 5, 2021 |
2 AOPs
|