AOP-Wiki

API

All KERs

Showing 1676 to 1700 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1231	1170: Increase, Phenotypic enzyme activity	1171: Increase, Clonal Expansion of Altered Hepatic Foci	Nov 29, 2016	Dec 3, 2016	None
2409	1892: increase, placental insufficiency	1893: increase, Preeclampsia	May 31, 2021	May 31, 2021	1 AOP 151: AhR activation leading to preeclampsia
254	220: Increase, Plasma vitellogenin concentrations	252: Increase, Renal pathology due to VTG deposition	Nov 29, 2016	Jun 24, 2024	2 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
3259	220: Increase, Plasma vitellogenin concentrations	364: Impaired development of, Reproductive organs	Jul 3, 2024	Jul 3, 2024	1 AOP 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
1474	1375: Increase, platelet aggregation	1367: Inhibit, gastric ulcer formation	Apr 17, 2017	Apr 17, 2017	1 AOP 217: Gastric ulcer formation
2555	1965: Increase, Pollen abnormal	1863: Decrease, Reproduction	Jan 21, 2022	Jan 21, 2022	1 AOP 435: Deposition of ionising energy leads to population decline via pollen abnormal
2070	1754: Increase, porcupine-induced Wnt secretion and Wnt signaling activation	1755: beta-catenin activation	Mar 23, 2020	Nov 9, 2021	1 AOP 298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
2634	623: Increase, predation	360: Decrease, Population growth rate	Apr 6, 2022	Apr 6, 2022	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
1744	1524: Increase, Premature molting	350: Increase, Mortality	May 24, 2018	Feb 17, 2021	5 AOPs 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
774	774: Increase, Preneoplastic foci (hepatocytes)	719: Increase, hepatocellular adenomas and carcinomas	Nov 29, 2016	Feb 15, 2017	3 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
2835	2097: Increase, Pro-Inflammatory Mediators	2098: Abnormal Neural Remodeling	Jan 25, 2023	Sep 10, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2839	2097: Increase, Pro-Inflammatory Mediators	341: Impairment, Learning and memory	Jan 25, 2023	Jul 26, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2339	1864: Increase, Programmed cell death	1479: Decrease, Leaf development	Apr 11, 2021	Apr 11, 2021	None
2553	1864: Increase, Programmed cell death	1863: Decrease, Reproduction	Jan 21, 2022	Jan 21, 2022	1 AOP 388: Deposition of ionising energy leading to population decline via programmed cell death
944	923: Increased goblet cell proliferation	921: Goblet cell hyperplasia	Nov 29, 2016	Aug 27, 2021	None
2090	1767: Increase, Protein oxidation	1768: Increase, Abnormal osmoregulation	Apr 30, 2020	Apr 30, 2020	1 AOP 327: Excessive reactive oxygen species production leading to mortality (1)
2223	1767: Increase, Protein oxidation	1825: Increase, Cell death	Dec 4, 2020	Dec 4, 2020	None
3361	1767: Increase, Protein oxidation	55: Cell injury/death	Oct 8, 2024	Oct 8, 2024	None
3568	1767: Increase, Protein oxidation	1994: Ferroptosis	Aug 13, 2025	Aug 13, 2025	None
3633	1767: Increase, Protein oxidation	1446: Decrease, Coupling of OXPHOS	Sep 8, 2025	Sep 8, 2025	1 AOP 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death
3634	1767: Increase, Protein oxidation	179: Decrease, Fatty acid β-oxidation	Sep 8, 2025	Sep 8, 2025	3 AOPs 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
3636	1767: Increase, Protein oxidation	1505: Cell cycle, disrupted	Sep 8, 2025	Sep 8, 2025	1 AOP 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption
2802	2077: behavioral change leading to possible reduced feeding opportunity	1521: Decrease, Growth	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
272	246: Increase, RBC congestion in liver	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
1696	1115: Increase, ROS	1491: increased, oncotic necrosis	Nov 14, 2017	Nov 14, 2017	1 AOP 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)

Key Event Relationships (KERs)

All KERs