AOP-Wiki

API

All KERs

Showing 2301 to 2325 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1940	887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)	1545: Decrease in mitochondrial oxidative phosphorylation	Jun 7, 2019	Jun 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
213	195: Inhibition, NMDARs	52: Decreased, Calcium influx	Nov 29, 2016	Apr 7, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
214	195: Inhibition, NMDARs	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	None
215	195: Inhibition, NMDARs	191: Neuronal dysfunction	Nov 29, 2016	Dec 3, 2016	None
3124	195: Inhibition, NMDARs	2208: Aberrant, synaptic formation and plasticity	Jan 25, 2024	Jan 25, 2024	1 AOP 522: Estrogen antagonism leading to increased risk of autism-like behavior
387	202: Inhibition, Nuclear factor kappa B (NF-kB)	152: Suppression, Inflammatory cytokines	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
1828	202: Inhibition, Nuclear factor kappa B (NF-kB)	1575: Activation, Caspase 8 pathway	Jan 7, 2019	Mar 7, 2019	1 AOP 278: IKK complex inhibition leading to liver injury
1871	202: Inhibition, Nuclear factor kappa B (NF-kB)	986: Impairment of TDAR	Mar 12, 2019	Mar 12, 2019	None
1921	202: Inhibition, Nuclear factor kappa B (NF-kB)	1569: Impaired T cell activation	May 23, 2019	Jun 25, 2019	None
2003	202: Inhibition, Nuclear factor kappa B (NF-kB)	1702: Suppression of T cell activation	Nov 17, 2019	Mar 2, 2023	1 AOP 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
2306	202: Inhibition, Nuclear factor kappa B (NF-kB)	1496: Increased proinflammatory mediators	Mar 30, 2021	Mar 30, 2021	None
2644	202: Inhibition, Nuclear factor kappa B (NF-kB)	1633: Increase in inflammation	Apr 8, 2022	Apr 8, 2022	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
1131	877: Inhibition, organic anion transporter 1 (OAT1)	1096: Increased, blood uric acid concentration	Nov 29, 2016	Dec 3, 2016	1 AOP 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
3652	2376: Inhibition, OATP1C1	2093: Decreased brain T4/T3	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1202	1155: Inhibition, Pendrin	277: TH synthesis, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 192: Pendrin inhibition leading to altered amphibian metamorphosis
836	828: Inhibition, Phospholipase A	829: Damage, Lipid bilayer	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
837	828: Inhibition, Phospholipase A	831: Disturbance, Lysosomal function	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
3154	828: Inhibition, Phospholipase A	177: Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
511	468: Inhibition, PPAR alpha	451: Inhibition, Mitochondrial fatty acid beta-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
799	798: Inhibition, Prolyl hydroxylases	799: Increased, HIF-1 heterodimer	Nov 29, 2016	Dec 3, 2016	1 AOP 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
3369	798: Inhibition, Prolyl hydroxylases	590: N/A, hypoxia	Oct 25, 2024	Oct 25, 2024	1 AOP 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
716	724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme	726: Increased, Induction of pyruvate dehydrogenase (PDH)	Nov 29, 2016	Dec 3, 2016	1 AOP 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
585	584: Inhibition, sodium channel	585: Decreased, Sodium conductance 1	Nov 29, 2016	Dec 3, 2016	3 AOPs 91: Sodium channel inhibition leading to reduced survival 93: sodium channel inhibition leading to increased predation 94: Sodium channel inhibition leading to congenital malformations
590	584: Inhibition, sodium channel	444: Increased, Atrioventricular block and bradycardia	Nov 29, 2016	Dec 3, 2016	None
1242	584: Inhibition, sodium channel	1176: Decreased, sodium conductance 2	Nov 29, 2016	Dec 3, 2016	1 AOP 197: Sodium channel (Nav1.1) inhibition leading to population decline

Key Event Relationships (KERs)

All KERs