Key Event Relationships (KERs)

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Showing 2351 to 2375 of 3002 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
953 934: Decrease, Tetrahydrobiopterin 932: Uncoupling, eNOS Nov 29, 2016 Oct 12, 2017
956 932: Uncoupling, eNOS 933: Depletion, Nitric Oxide Nov 29, 2016 Oct 12, 2017
3014 932: Uncoupling, eNOS 2161: Increase, Vascular disrupting effects Aug 21, 2023 Aug 21, 2023 None
3023 932: Uncoupling, eNOS 1928: increased，Vascular endothelial dysfunction Aug 21, 2023 Aug 21, 2023
988 973: Decrease, AKT/eNOS activity 933: Depletion, Nitric Oxide Nov 29, 2016 Oct 16, 2017
958 933: Depletion, Nitric Oxide 937: Impaired, Vasodilation Nov 29, 2016 Oct 12, 2017
982 937: Impaired, Vasodilation 951: Increase, Vascular Resistance Nov 29, 2016 Oct 13, 2017
983 951: Increase, Vascular Resistance 952: Hypertension Nov 29, 2016 Oct 13, 2017
2152 1795: TGFbeta expression 1283: Activation, TGF-beta pathway Jul 9, 2020 Jul 9, 2020
1778 1494: Leukocyte recruitment/activation 265: Activation, Stellate cells Nov 12, 2018 Nov 12, 2018
1901 1494: Leukocyte recruitment/activation 1182: Increase, Cell Proliferation (Epithelial Cells) May 7, 2019 May 7, 2019 None
1905 1494: Leukocyte recruitment/activation 1632: Increase in RONS May 7, 2019 May 9, 2019
2891 1494: Leukocyte recruitment/activation 1501: Increased extracellular matrix deposition Apr 13, 2023 Apr 13, 2023 None
1728 1511: Lipid Peroxidation 1509: Protein Adduct Formation Apr 4, 2018 Apr 5, 2018
1731 1511: Lipid Peroxidation 1513: General Apoptosis Apr 4, 2018 Apr 5, 2018
3377 1511: Lipid Peroxidation 1442: Foam cell formation Oct 30, 2024 Oct 30, 2024 None
1500 1389: Locomotor activity, decreased 1141: Decreased, Reproductive Success May 8, 2017 Jun 26, 2017
1705 1498: Loss of alveolar capillary membrane integrity 1499: Activation of Th2 cells Jan 5, 2018 May 16, 2023
2174 1498: Loss of alveolar capillary membrane integrity 1676: Blood extravasation into the lungs Oct 22, 2020 Oct 22, 2020 None
2258 1498: Loss of alveolar capillary membrane integrity 1833: Impaired lung function Jan 8, 2021 Jan 8, 2021 None
2259 1498: Loss of alveolar capillary membrane integrity 1671: Substance - LS interaction Jan 8, 2021 Jan 8, 2021 None
2368 1498: Loss of alveolar capillary membrane integrity 1672: Inhibition of LS function. Apr 27, 2021 Apr 27, 2021
2369 1498: Loss of alveolar capillary membrane integrity 1677: Reduced tidal volume Apr 27, 2021 Apr 27, 2021
2372 1498: Loss of alveolar capillary membrane integrity 1250: Decreased lung function Apr 27, 2021 Apr 27, 2021
1972 1675: Loss of barrier function 1676: Blood extravasation into the lungs Jul 3, 2019 Jul 3, 2019 None