Prototypical Stressors

Showing 601 to 625 of 848 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

821	Physostigmine		559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
846	Picoxystrobin	Picoxystrobin, CAS-RN: 117428-22-5, DTXSID9047542	587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits
110	Picrotoxin	Picrotoxin, CAS-RN: 124-87-8, DTXSID7045605	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
823	Pilocarpine		559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
529	Pimecrolimus	Pimecrolimus, CAS-RN: 137071-32-0, DTXSID2046674	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
200	pindone	Pindone, CAS-RN: 83-26-1, DTXSID1025930	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
765	Piperonyl butoxide	Piperonyl butoxide, CAS-RN: 51-03-6, DTXSID1021166	None
205	pirinixic acid	Pirinixic acid, CAS-RN: 50892-23-4, DTXSID4020290	37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
718	Platinum		None
528	PM 2.5		319: Binding to ACE2 leading to lung fibrosis
660	PM10		None
125	Podofilox	Podofilox, CAS-RN: 518-28-5, DTXSID3045645	None
513	Podophyllotoxin		None
257	Polybrominated diphenyl ethers		152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
148	Polychlorinated biphenyl		5 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 131: Aryl hydrocarbon receptor activation leading to uroporphyria 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
780	Polychlorinated biphenyls; mixture of specific PCBs	Polychlorinated biphenyls; mixture of specific PCBs, CAS-RN: NOCAS, DTXSID0040591	504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
256	Polychlorinated dibenzodioxins		2 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
149	Polychlorinated dibenzofurans		150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
347	Polycyclic aromatic hydrocarbons	Polycyclic aromatic hydrocarbons, CAS-RN: 130498-29-2, DTXSID3044043	None
250	Polycyclic aromatic hydrocarbons (PAHs)		5 AOPs 131: Aryl hydrocarbon receptor activation leading to uroporphyria 397: Bulky DNA adducts leading to mutations 550: Increased LMNA gene mutation leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
769	Polyethylene AS low Mol.Wt.	Polyethylene AS low Mol.Wt., CAS-RN: 9002-88-4, DTXSID8031946	505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
331	Polymyxin B	Polymyxin B, CAS-RN: 1404-26-8, DTXSID1048467	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
369	Polyoxin B	Polyoxin B, CAS-RN: 19396-06-6, DTXSID3058329	360: Chitin synthase 1 inhibition leading to mortality
593	Polyoxin D		360: Chitin synthase 1 inhibition leading to mortality
770	Polyvinyl chloride	Polyvinyl chloride, CAS-RN: 9002-86-2, DTXSID5025940	505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway