Prototypical Stressors

Showing 526 to 550 of 848 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

301	NFE2/Nrf2 repression		232: NFE2/Nrf2 repression to steatosis
759	NH-375		485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
722	Nickel	Nickel, CAS-RN: 7440-02-0, DTXSID2020925	None
743	Niclosamide ethanolamine		263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
657	Nicotine	Nicotine, CAS-RN: 54-11-5, DTXSID1020930	None
382	Nifedipine	Nifedipine, CAS-RN: 21829-25-4, DTXSID2025715	2 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
368	Nikkomycins	Nikkomycins, CAS-RN: 59456-70-1, DTXSID5058436	360: Chitin synthase 1 inhibition leading to mortality
193	nimesulide	Nimesulide, CAS-RN: 51803-78-2, DTXSID3037250	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
386	Nimodipine	Nimodipine, CAS-RN: 66085-59-4, DTXSID5023370	2 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
385	Nisoldipine	Nisoldipine, CAS-RN: 63675-72-9, DTXSID0023371	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
185	Nitazoxanide	Nitazoxanide, CAS-RN: 55981-09-4, DTXSID5033757	None
140	Nitisinone		None
67	Nitrate	Nitrate, CAS-RN: 14797-55-8, DTXSID5024217	54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
387	Nitrendipine	Nitrendipine, CAS-RN: 39562-70-4, DTXSID0023373	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
661	Nitric oxide	Nitric oxide, CAS-RN: 10102-43-9, DTXSID1020938	None
465	nitrofen	Nitrofen, CAS-RN: 1836-75-5, DTXSID7020970	2 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
673	Nitrogen dioxide	Nitrogen dioxide, CAS-RN: 10102-44-0, DTXSID7020974	411: Oxidative stress Leading to Decreased Lung Function
365	Nitrogen mustard	Nitrogen mustard, CAS-RN: 51-75-2, DTXSID2020975	None
237	Nitrotoluenes (hypothesized binding)		6: Antagonist binding to PPARα leading to body-weight loss
127	Nocodazole	Nocodazole, CAS-RN: 31430-18-9, DTXSID9031800	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
436	None		None
275	NonSteroidal Anti-Inflammatory Drugs (NSAID)		217: Gastric ulcer formation
797	Norepinephrine		554: β-adrenergic receptor agonists leading to arrhythmias.
390	Norfloxacin	Norfloxacin, CAS-RN: 70458-96-7, DTXSID7037680	144: Endocytic lysosomal uptake leading to liver fibrosis
234	norfluoxetine		203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline