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Showing 301 to 325 of 548 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
359 Chitobiase inhibition leading to mortality Cataia Ives All rights reserved 1807: Inhibition, Chitobiase 350: Increase, Mortality Under Development 1.94
360 Chitin synthase 1 inhibition leading to mortality Brendan Ferreri-Hanberry BY-SA 1522: Inhibition, Chitin synthase 1 350: Increase, Mortality WPHA/WNT Endorsed 1.94
361 Sulfonylureareceptor binding leading to mortality Arthur Author All rights reserved 1525: Increase, Sulfonylurea receptor binding 350: Increase, Mortality Under Development 1.94
362 Immune mediated hepatitis Agnes Aggy BY-SA 1814: benzoquinone imine and acylglucuronide metabolites 1820: Immune mediated hepatitis
363 Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure Allie Always BY-SA 279: Thyroperoxidase, Inhibition Under Review 1.35
364 Thyroperoxidase inhibition leading to altered visual function via decreased eye size Evgeniia Kazymova All rights reserved 279: Thyroperoxidase, Inhibition Under Development 1.35
365 Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning Cataia Ives All rights reserved 279: Thyroperoxidase, Inhibition Under Development 1.35
366 Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry BY-SA 957: Binding, Transthyretin in serum 1101: Altered, Amphibian metamorphosis
367 Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Arthur Author BY-SA 1831: Binding, Thyroid binding globulin in serum 1101: Altered, Amphibian metamorphosis
368 Cytochrome oxidase inhibition leading to increased nasal lesions Agnes Aggy BY-SA 1840: Inhibition, cytochrome oxidase 2312: Increased, nasal lesions
369 Photosystem II antagonism leading to growth inhibition via oxidative damage Allie Always BY-SA None None
370 Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis Evgeniia Kazymova BY-SA None None
371 Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone Cataia Ives BY-SA None None
372 Androgen receptor antagonism leading to testicular cancer Brendan Ferreri-Hanberry BY-SA 26: Antagonism, Androgen receptor 1839: Testicular Cancer
373 Mitochondrial dysfunction to metabolic diseases Arthur Author BY-SA None None
374 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Agnes Aggy All rights reserved 1739: Binding to ACE2 1841: Encephalitis Under Development 1.96
375 test AOP Allie Always BY-SA None None
376 Androgen receptor agonism leading to male-biased sex ratio Evgeniia Kazymova BY-SA 25: Agonism, Androgen receptor 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
377 Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) Cataia Ives BY-SA 1842: Prolonged TLR9 activation
378 Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Brendan Ferreri-Hanberry BY-SA 1848: Toll Like Receptor (TLR) Dysregulation None
379 Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation Arthur Author All rights reserved 1739: Binding to ACE2 1846: Thrombosis and Disseminated Intravascular Coagulation Under Development 1.96
381 Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Agnes Aggy BY-SA 1739: Binding to ACE2 1850: dysgeusia Under Development 1.96
382 Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Allie Always BY-SA 1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) 1276: Lung fibrosis Under Development 1.96
383 Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Evgeniia Kazymova BY-SA 1740: Induced dysregulation of ACE2 344: N/A, Liver fibrosis Under Development 1.96
384 Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Cataia Ives BY-SA 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1603: Chronic kidney disease