AOPs

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Showing 476 to 500 of 582 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
536 Estrogen receptor agonism leading to reduced survival and population growth due to renal failure Cataia Ives BY-SA 111: Agonism, Estrogen receptor None
537 Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver Brendan Ferreri-Hanberry BY-SA 111: Agonism, Estrogen receptor 78: Reduction, Cumulative fecundity and spawning
538 Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways Arthur Author BY-SA None 2161: Increase, Vascular disrupting effects
539 Decreased Sodium/Potassium ATPase activity leads to Heart failure Agnes Aggy BY-SA 1562: Decreased Na/K ATPase activity 1535: Heart failure
540 Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production Allie Always BY-SA 1115: Increase, Reactive oxygen species 360: Decrease, Population growth rate
541 Excessive ROS generation leading to increased incidence of vascular calcification by VSMC phenotype switching Evgeniia Kazymova BY-SA None None
543 Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration Cataia Ives BY-SA 2262: Neuropathy target esterase, inhibited 2267: Delayed neuropathy, increased
544 Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation Brendan Ferreri-Hanberry BY-SA 2262: Neuropathy target esterase, inhibited 2267: Delayed neuropathy, increased
545 Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis Arthur Author BY-SA 239: Activation, Pregnane-X receptor, NR1I2 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
546 Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms Agnes Aggy BY-SA 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer
547 Androgen receptor agonism leading to long anogenital distance in female offspring Allie Always All rights reserved 25: Agonism, Androgen receptor 2365: Anogenital distance (AGD), increased
548 Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression Evgeniia Kazymova BY-SA 239: Activation, Pregnane-X receptor, NR1I2 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
549 Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish Cataia Ives BY-SA 36: Inhibition, Aromatase
550 Increased LMNA gene mutation leading to heart failure Brendan Ferreri-Hanberry BY-SA 2278: Increased LMNA Mutation 1535: Heart failure
551 Increased Muscarinic M2 Receptor leading to Arrhythmia Arthur Author Open for adoption 1602: Increased Muscarinic Acetylcholine Receptors 1106: Occurrence, cardiac arrhythmia
552 Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) Agnes Aggy BY-SA 1529: Blockade, L-Type Calcium Channels 1535: Heart failure
553 Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure Allie Always BY-SA 584: Inhibition, sodium channel 1535: Heart failure
554 β-adrenergic receptor agonists leading to arrhythmias. Evgeniia Kazymova BY-SA 1038: Activation, beta-2 adrenergic receptor 1106: Occurrence, cardiac arrhythmia
555 Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure Cataia Ives BY-SA 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel 1535: Heart failure
556 Decreased Na/K ATPase activity leading to heart failure Brendan Ferreri-Hanberry BY-SA 1562: Decreased Na/K ATPase activity 1535: Heart failure
557 β2-Receptor agonist leading to Cardiomyopathy Arthur Author BY-SA 1039: Increased activity, beta-2 adrenergic receptor 2157: Abnormal Cardiac Structure and Function
558 Phosphodiesterase inhibition leading to heart failure Agnes Aggy BY-SA 2288: Phosphodiesterase inhibition 1535: Heart failure
559 Inhibition of acetylcholinesterase (AChE) leading to arrhythmias Allie Always BY-SA 12: Acetylcholinesterase (AchE) Inhibition 1106: Occurrence, cardiac arrhythmia
560 Inhibition of Funny current (If) leading to Arrhythmias Evgeniia Kazymova Open for adoption 2290: Inhibition of Funny current (If) 1106: Occurrence, cardiac arrhythmia
561 Aromatase induction leading to estrogen receptor alpha activation via increased estradiol Cataia Ives BY-SA 2293: Aromatase, induction 1065: Activation, estrogen receptor alpha