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Showing 476 to 500 of 548 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
537 Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver Brendan Ferreri-Hanberry BY-SA 111: Agonism, Estrogen receptor 78: Reduction, Cumulative fecundity and spawning
538 Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways Arthur Author All rights reserved None 2161: Increase, Vascular disrupting effects
539 Decreased Sodium/Potassium ATPase activity leads to Heart failure Agnes Aggy BY-SA 1562: Decreased Na/K ATPase activity 1535: Heart failure
540 Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production Allie Always All rights reserved 1115: Increase, Reactive oxygen species 360: Decrease, Population growth rate
541 Excessive ROS generation leading to increased incidence of vascular calcification by VSMC phenotype switching Evgeniia Kazymova All rights reserved None None
543 Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration Cataia Ives All rights reserved 2262: Neuropathy target esterase, inhibited 2267: Delayed neuropathy, increased
544 Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation Brendan Ferreri-Hanberry All rights reserved 2262: Neuropathy target esterase, inhibited 2267: Delayed neuropathy, increased
545 Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis Arthur Author BY-SA 239: Activation, Pregnane-X receptor, NR1l2 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
546 Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms Agnes Aggy All rights reserved 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer
547 Androgen receptor agonism leading to long anogenital distance in female offspring Allie Always All rights reserved 25: Agonism, Androgen receptor 2365: Anogenital distance, increased
548 Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression Evgeniia Kazymova BY-SA 239: Activation, Pregnane-X receptor, NR1l2 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
549 Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish Cataia Ives BY-SA 36: Inhibition, Aromatase
550 Increased LMNA gene mutation leading to heart failure Brendan Ferreri-Hanberry BY-SA 2278: Increased LMNA Mutation 1535: Heart failure
551 Increased Muscarinic M2 Receptor leading to Arrhythmia Arthur Author Open for adoption 1602: Increased Muscarinic Acetylcholine Receptors 1106: Occurrence, cardiac arrhythmia
552 Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) Agnes Aggy All rights reserved 1529: Blockade, L-Type Calcium Channels 1535: Heart failure
553 Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure Allie Always All rights reserved 584: Inhibition, sodium channel 1535: Heart failure
554 β-adrenergic receptor agonists leading to arrhythmias. Evgeniia Kazymova All rights reserved 1038: Activation, beta-2 adrenergic receptor 1106: Occurrence, cardiac arrhythmia
555 Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure Cataia Ives All rights reserved 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel 1535: Heart failure
556 Decreased Na/K ATPase activity leading to heart failure Brendan Ferreri-Hanberry All rights reserved 1562: Decreased Na/K ATPase activity 1535: Heart failure
557 β2-Receptor agonist leading to Cardiomyopathy Arthur Author All rights reserved 1039: Increased activity, beta-2 adrenergic receptor 2157: Abnormal Cardiac Structure and Function
558 Phosphodiesterase inhibition leading to heart failure Agnes Aggy All rights reserved 2288: Phosphodiesterase inhibition 1535: Heart failure
559 Inhibition of acetylcholinesterase (AChE) leading to arrhythmias Allie Always All rights reserved 12: Acetylcholinesterase (AchE) Inhibition 1106: Occurrence, cardiac arrhythmia
560 Inhibition of Funny current (If) leading to Arrhythmias Evgeniia Kazymova Open for adoption 2290: Inhibition of Funny current (If) 1106: Occurrence, cardiac arrhythmia
561 Aromatase induction leading to estrogen receptor alpha activation via increased estradiol Cataia Ives All rights reserved 2293: Aromatase, induction 1065: Activation, estrogen receptor alpha
562 HCN Channel Inhibition leading to Arrhythmias Brendan Ferreri-Hanberry All rights reserved 2295: HCN Channel Inhibition 1106: Occurrence, cardiac arrhythmia