EDSP

Export CSV API

AOP Collection · Draft · Created by Dan Villeneuve

Purpose
A collection of AOPs linking endocrine MIEs or early KEs to endpoints measured in guideline studies relevant to the U.S. Endocrine Disruptor Screening Program.

AOPs in this Collection (24)

ID Title License OECD Status
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) BY-SA WPHA/WNT Endorsed
25 Aromatase inhibition leading to reproductive dysfunction BY-SA WPHA/WNT Endorsed
29 Estrogen receptor agonism leading to reproductive dysfunction BY-SA
30 Estrogen receptor antagonism leading to reproductive dysfunction BY-SA Under Review
146 Estrogen Receptor Activation and Female Precocious Puberty Open for adoption
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats BY-SA
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring BY-SA Under Review
344 Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring BY-SA Under Development
345 Androgen receptor (AR) antagonism leading to decreased fertility in females BY-SA Under Development
346 Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation BY-SA WPHA/WNT Endorsed
372 Androgen receptor antagonism leading to testicular cancer BY-SA
376 Androgen receptor agonism leading to male-biased sex ratio BY-SA WPHA/WNT Endorsed
445 Estrogen Receptor Alpha Agonism leads to Impaired Reproduction BY-SA
477 Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring BY-SA
495 Androgen receptor activation leading to prostate cancer BY-SA
536 Estrogen receptor agonism leading to reduced survival and population growth due to renal failure BY-SA
547 Androgen receptor agonism leading to long anogenital distance in female offspring All rights reserved
609 Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release BY-SA
619 Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues BY-SA
623 Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release BY-SA
637 Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining BY-SA
639 Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release BY-SA
640 Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle BY-SA
641 Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries BY-SA
Return to Collections List