AOPs in this Collection (16)

ID Title License OECD Status
1 Uncharacterized liver damage leading to hepatocellular carcinoma BY-SA
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors BY-SA
240 DNA Adducts Leading to Liver Hemangiosarcoma BY-SA
273 Mitochondrial complex inhibition leading to liver injury BY-SA
278 IKK complex inhibition leading to liver injury BY-SA
285 Inhibition of N-linked glycosylation leads to liver injury BY-SA
454 PM2.5-related AOP frameworks on liver diseases BY-SA
494 AhR activation leading to liver fibrosis BY-SA
514 PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV BY-SA
517 Pregnane X Receptor (PXR) activation leads to liver steatosis BY-SA
518 Liver X Receptor (LXR) activation leads to liver steatosis BY-SA
529 Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis BY-SA
537 Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver BY-SA
591 DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration BY-SA
638 Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis BY-SA
642 Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation BY-SA