Key Event Relationships (KERs)

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Showing 2626 to 2650 of 3002 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3632 1392: Oxidative Stress 1767: Increase, Protein oxidation Sep 8, 2025 Sep 8, 2025
1282 1231: Oxidization of biomolecules, Lipid bilayer and cellular proteins 1215: TRPA1 activation, TRPA1 Receptor Nov 29, 2016 Dec 3, 2016 None
1285 1231: Oxidization of biomolecules, Lipid bilayer and cellular proteins 1236: Generation of novel epitopes , Antigen presentation Nov 29, 2016 Dec 3, 2016 None
1286 1231: Oxidization of biomolecules, Lipid bilayer and cellular proteins 1234: Production of nerve growth factor , Epithelial irritation Nov 29, 2016 Dec 3, 2016 None
1711 1504: p21 (CDKN1A) expression, increase 1505: Cell cycle, disrupted Jan 21, 2018 Jul 25, 2018 None
3083 896: Parkinsonian motor deficits 350: Increase, Mortality Oct 17, 2023 Oct 17, 2023
236 209: Peptide Oxidation 134: Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) Nov 29, 2016 Dec 3, 2016 None
764 209: Peptide Oxidation 719: Increase, hepatocellular adenomas and carcinomas Nov 29, 2016 Dec 3, 2016 None
765 209: Peptide Oxidation 768: Increase, Cytotoxicity Nov 29, 2016 Dec 3, 2016
922 209: Peptide Oxidation 177: Mitochondrial dysfunction Nov 29, 2016 Nov 29, 2016 None
923 209: Peptide Oxidation 87: Release, Cytokine Nov 29, 2016 Dec 3, 2016 None
932 209: Peptide Oxidation 357: Cholestasis, Pathology Nov 29, 2016 Dec 3, 2016
948 209: Peptide Oxidation 926: Oxidation, Glutathione Nov 29, 2016 Nov 29, 2016 None
980 209: Peptide Oxidation 935: Decrease, GTPCH-1 Nov 29, 2016 Sep 28, 2017
992 209: Peptide Oxidation 973: Decrease, AKT/eNOS activity Nov 29, 2016 Oct 16, 2017
1237 209: Peptide Oxidation 1172: Increased activation, Nuclear factor kappa B (NF-kB) Nov 29, 2016 Dec 3, 2016 None
1379 209: Peptide Oxidation 1292: Activation, JNK Feb 15, 2017 Feb 15, 2017
1467 209: Peptide Oxidation 1194: Increase, DNA Damage Apr 15, 2017 Apr 15, 2017 None
1698 209: Peptide Oxidation 927: S-Glutathionylation, eNOS Nov 16, 2017 Nov 20, 2017
2516 1947: Pericyte dysfunction 1913: Endothelial cell dysfunction Oct 28, 2021 Oct 28, 2021 None
395 228: demethylation, PPARg promoter 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Nov 29, 2016 Dec 3, 2016 None
411 228: demethylation, PPARg promoter 54: Up Regulation, CD36 Nov 29, 2016 Nov 29, 2016
487 228: demethylation, PPARg promoter 457: Activation, SREBF1 Nov 29, 2016 Dec 3, 2016
1402 228: demethylation, PPARg promoter 1301: Activation, SREBP-1 Apr 12, 2017 Apr 12, 2017 None
1424 228: demethylation, PPARg promoter 116: Activation, FAS Apr 13, 2017 Apr 13, 2017 None